Zerodol P Tablet 10

Ipca Laboratories Pvt Ltd.

Strip of 10 Units

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Composition

Aceclofenac (100 Mg) + Paracetamol/acetaminophen (325 Mg)

Zerodol P Tablet is used in the treatment of pain and inflammation associated with dental, gynecological, and other minor surgical procedures.

It is a combination medicine that belongs to the group of medications called pain relievers. It is used to relieve pain and inflammation in acute musculoskeletal disorders such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and cervical spondylitis.

Zerodol P Tablet composition includes aceclofenac and paracetomol that helps in relieving pain and inflammation.

This tablet is generally safe and effective when used as prescribed. Some side effects may be noted with the use of this tablet, which should be timely informed to a doctor. Any allergy to this tablet, existing diseases and other ongoing medications should also be brought to the notice of your doctor before this tablet is prescribed to you.

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The uses of Zerodol-P Tablet are as follows:

Osteoarthritis (joint pain)
Rheumatoid arthritis (painful swelling of joints)
Ankylosing spondylitis (arthritis of the spine)
Periarthritis (painful swelling around joints)
Tenosynovitis (inflammation of sheath around tendons)
Dental procedures

Take a Zerodol-P with one whole glass of water.
You can take the Zerodol-P with or without food.
Swallow the Zerodol-P as a whole; do not crush or chew it.
Take the Zerodol-P at a fixed time each day to maintain a consistent level of medication.

Zerodol-P Tablet is taken orally.

The common side effects of Zerodol-P Tablet:

Nausea
Dizziness
Diarrhoea
Stomach upset
Stomach pain
Loss of appetite
Indigestion

Managing the Side Effects:

Most of the above-mentioned side effects resolve on discontinuation of the Zerodol P tablet. These are temporary and, in the majority of cases, do not require medical attention. If you experience nausea and diarrhoea, take this tablet with food. If you experience severe or persistent side effects from this tablet, consult your doctor.

Zerodol-P Tablet contains the following components:

Aceclofenac (100 mg): It is an NSAID that inhibits the cyclooxygenase-2 enzyme, which is involved in the production of prostaglandins. These chemical messengers are key to inflammation, pain, and fever. By blocking the action of cyclooxygenases-2 enzyme, aceclofenac reduces the inflammation, pain, and fever associated with musculoskeletal disorders, joint pain, and injuries.
Paracetamol/Acetaminophen (325 mg): It is an analgesic and antipyretic agent. It inhibits prostaglandin synthesis in the brain to reduce fever and pain.

Pregnancy

Is it safe to use Zerodol-P Tablet during pregnancy?

It should be used cautiously during pregnancy, particularly during the third trimester. It is advisable to consult your doctor if you are pregnant or planning to become pregnant before taking this medication.

Breastfeeding

Is it safe to consume Zerodol-P Tablet during breastfeeding?

Zerodol-P Tablet is not recommended in breastfeeding women. This tablet may pass into breast milk and adversely affect the nursing infant. It is recommended to consult your physician before using this medication if you are breastfeeding.

Alcohol

Is it safe to drink alcohol while taking Zerodol-P Tablet?

Consumption of alcohol should be avoided or minimised while taking this tablet, as it may increase the risk of gastrointestinal side effects. It may also potentiate the drowsiness caused by the medication.

Liver

Is it advisable to take Zerodol-P Tablet when experiencing liver problems?

Individuals with liver disease or impaired liver function are not recommended to take Zerodol-P Tablet. You must consult your doctor before using this medication if you have any liver-related conditions.

Kidney

Is it advisable to consume Zerodol-P Tablet when experiencing kidney problems?

Patients with severe kidney impairment are not recommended to take Zerodol-P Tablet. Inform your doctor if you have severe kidney impairment before taking this tablet.

Using Machines & Driving

Is it safe to operate heavy machinery or drive when using the Zerodol-P Tablet?

Zerodol-P Tablet may cause dizziness or drowsiness in some individuals. If you experience these side effects, avoiding activities requiring mental alertness, such as operating machinery or driving a vehicle, is essential.

Allergy

Are there any specific conditions that should be considered before taking Zerodol-P Tablet?

Avoiding this medication is essential if you have a known allergy to aceclofenac or paracetamol. Read the label and check the ingredients before taking this tablet to avoid allergic reactions.

Children

Is Zerodol-P Tablet suitable for infants or children?

It is recommended to consult a paediatrician before giving this medication to children.

Older Patients

Is Zerodol-P Tablet suitable for older patients?

Elderly individuals may be more susceptible to the side effects of Zerodol-P Tablet. Close monitoring and dose adjustments may be necessary. Consulting a doctor is advisable for proper guidance.

Drug-Drug Interactions

Zerodol-P Tablet may interact with medications, including:

Anti-hypertensives such as losartan, enalapril, and metoprolol. This tablet may reduce the effect of anti-hypertensive medications. The concomitant use may further damage kidney function.
Antidiabetic medications such as metformin, glipizide, and sitagliptin. The concomitant use may show hypoglycaemic and hyperglycaemic effects.
Diuretics such as furosemide and spironolactone. These medications can increase the risk of nephrotoxicity of this tablet.
Cardiac glycosides such as digoxin. This tablet can reduce the clearance of this digoxin.
Cancer medications, such as methotrexate. This tablet may reduce the elimination of methotrexate.
Corticosteroids such as prednisone. The concomitant use of this tablet with corticosteroids may increase the risk of gastrointestinal ulceration or bleeding.
Anticoagulants such as warfarin. This tablet may enhance the effects of warfarin. The concomitant may increase the risk of gastrointestinal ulceration or bleeding.
Quinolone antibiotics such as ciprofloxacin and levofloxacin. This tablet can increase the risk of convulsions associated with these medications.
Immunosuppressants such as cyclosporine and tacrolimus. The concomitant use may increase the risk of a decrease in bone marrow and blood cells.
Cholesterol-lowering medications such as cholestyramine. The absorption of this tablet may be reduced by cholestyramine.
Other NSAIDs. The concomitant therapy with aspirin or other NSAIDs may increase the frequency of adverse reactions, including the risk of gastrointestinal bleeding.

Drug-Disease Interactions

Zerodol-P Tablet may interact with diseases, including:

Liver and kidney disease: The tablet can increase the effects on the liver and kidney. In individuals with liver disease, it should be used cautiously, and dosage adjustments may be necessary.
Peptic ulcers: This tablet may aggravate peptic ulcers.
Bleeding disorders: It can increase the risk of bleeding due to its anti-inflammatory properties.
Heart diseases: This tablet may further worsen the existing heart condition.

Daily Dose

The recommended dose of Zerodol-P Tablet should be taken as prescribed by your doctor. The dosage may vary depending on individual factors, such as the severity of the condition and response to treatment. Following the prescribed dosage and consulting your doctor before exceeding it is essential.

Over Dose

If you or someone else takes an excessive Zerodol-P Tablet, seek immediate medical attention from your doctor or nearby hospital. Symptoms of an overdose may include nausea, vomiting, pain abdomen, dizziness, drowsiness, and headache.

Missed Dose

If you forget to take this tablet, take it as soon as you remember. If the time for the next dose is close, skip the missed dose and resume your regular dosage pattern. Only increase your dosage after consulting your doctor. Always follow the instructions given by your doctor.

Store this medicine at room temperature (15-25ºC).
Protect it from light and moisture.
Keep Zerodol-P Tablet away from children.
Do not use this medicine after the expiry date has passed.

Soak in a warm epsom salt bath to relax muscles and reduce inflammation.
You may apply a warm compress or ice pack to affected areas for relief from muscle spasms.
Gentle massages with warm oils can help relax muscles and improve circulation.
Perform gentle stretches to improve flexibility and prevent muscle stiffness. Avoid overstretching, especially if you have an injury.
Elevate the affected area and rest to minimise strain on muscles.
Choose comfortable, supportive shoes to minimise the impact on joints and muscles.
Maintain a healthy weight to alleviate stress on joints, which is particularly important for conditions like arthritis.

Fact Box

Drug Category	Non-steroidal Anti-inflammatory Drugs (NSAIDs), antipyretics and analgesics
Therapeutic Category	Pain and Inflammation
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Arthritis, muscle pain

What is Zerodol-P used for?

This tablet is primarily used to alleviate pain and inflammation associated with conditions such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, cervical spondylitis, and sciatica. It is also effective in managing post-operative and traumatic inflammations, as well as painful inflammatory conditions in gynaecology and dentistry.

Is Zerodol-P good for nerve pain?

This tablet is effective for relieving nerve pain associated with conditions like sciatica, as it contains a combination of analgesic and anti-inflammatory drugs that help alleviate pain and reduce inflammation in the affected nerves.

How long does Zerodol-P Tablet take to work?

Zerodol-P Tablet typically starts to work within 30 minutes to an hour after ingestion. However, the onset of action may vary depending on factors such as the severity of pain, metabolism, and other medical conditions.

What are the benefits of Zerodol P Tablet?

Zerodol P Tablet benefits includes relieving pain and inflammation associated with dental, gynecological, and minor surgical procedures.

Is Zerodol-P Tablet harmful to the kidneys?

This tablet can potentially cause kidney damage with long-term use. It is essential to consult your doctor if you have underlying kidney disease before taking this medication.

Who should not take Zerodol-P Tablet?

This tablet is not recommended for individuals with allergies to aceclofenac, paracetamol, or any other NSAIDs. It should also be avoided in patients with kidney, liver, and alcohol problems.

Is Zerodol-P Tablet an antibiotic?

This tablet is not an antibiotic. It is a combination medication that contains aceclofenac and paracetamol, which are non-steroidal anti-inflammatory drugs (NSAIDs).

Can I stop taking Zerodol-P Tablet when my pain is relieved?

It is essential to follow your doctor's instructions regarding the duration of treatment with this tablet. Abruptly stopping the medication may lead to a recurrence of symptoms. Consult your doctor before discontinuing the tablet.

Last Updated On 11 Jun. 2024 | 9:36AM (IST)

Certified Content

Written by

Dr. Sachin Singh

Medical Team Lead | 5 years

MBBS

Reviewed by

Dr. Mandeep Chadha

Lead Medical Content Reviewer | 10 years

MBBS, DNB (OBGY)

Check out Editorial Policy

References

Aceclofenac 100 mg Film-coated Tablets - Summary of Product Characteristics (SmPC) - (emc). (n.d.). Org.uk. Retrieved September 18, 2023, from https://www.medicines.org.uk/emc/product/2389/smpc
Paracetamol 500mg Tablets - Summary of Product Characteristics (SmPC) - (emc). (n.d.). Org.uk. Retrieved September 18, 2023, from https://www.medicines.org.uk/emc/product/5164/smpc
Acetaminophen. (n.d.). Medlineplus.Gov. Retrieved August 7, 2023, from https://medlineplus.gov/druginfo/meds/a681004.html
Tripathi, K. D. (2019). Nonsteroidal Antiinflammatory Drugs and Antipyretic-Analgesics, Skeletal Muscle Relaxants. In Essentials of Medical Pharmacology (8th ed., pp. 221,223,384). essay, Jaypee Brothers Medical Publishers.
PubChem. (n.d.). Aceclofenac. Nih.Gov. Retrieved August 7, 2023, from https://pubchem.ncbi.nlm.nih.gov/compound/71771
ACECLOFENAC AND PARACETAMOL TABLETS. (N.d.). Gov.Ng. Retrieved February 29, 2024, from https://www.nafdac.gov.ng/wp-content/uploads/Files/SMPC/November_2022_Revised/Acel-Plus-Tablets.pdf

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