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Cefoperazone + Tazobactam

Uses of Cefoperazone + Tazobactam

  • Cefoperazone + Tazobactam is mainly used to manage various bacterial infections (such as intra-abdominal infections, respiratory tract infections, skin infections, urinary tract infections, septicaemia, and bacterial meningitis). It belongs to the group of cephalosporin antibiotics.

Side effects of Cefoperazone + Tazobactam

  • Diarrhoea

  • Nausea

  • Vomiting

  • Abdominal pain

  • Local injection site reactions

How Cefoperazone + Tazobactam works

  • Cefoperazone + Tazobactam is a combination antibiotic.

  • Cefoperazone, a third-generation cephalosporin, works by inhibiting bacterial cell wall synthesis. It attaches to and inactivates penicillin-binding proteins (PBPs), which are enzymes involved in the synthesis of bacterial cell walls. It, thus, weakens the cell wall, causing the cell to break apart and die.

  • Tazobactam is a beta-lactamase inhibitor. Some bacteria produce beta-lactamase enzymes that can deactivate antibiotics like cefoperazone. Tazobactam prevents these enzymes from working, thus protecting cefoperazone and allowing it to kill bacteria that produce beta-lactamase.

Certified content

Written By

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Dr. Michelle FrankMedical Content Writer| 8 years

Doctor of Medicine

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Cefoperazone + Tazobactam is administered through the intravenous route, meaning it is injected directly into a vein.

Age and Dose Restrictions

  • It is intended for use in adults. The dosage varies based on the type and severity of the infection to be managed.

Contraindications

  • This combination is contraindicated in patients with known hypersensitivity to either cefoperazone or tazobactam.

  • It is also contraindicated in those with a known allergy to other beta-lactam antibiotics, such as penicillins or cephalosporins.

Other Medications to Avoid

  • This combination can interact with aminoglycoside antibiotics (such as gentamicin and amikacin), anticoagulants (like warfarin and heparin), and gout medications (such as probenecid).

  • It's also essential to avoid concurrent use of this combination with live bacterial vaccines (for example, typhoid vaccine).

Overdose and Missed Dose

  • An overdose of Cefoperazone + Tazobactam can lead to nausea, vomiting, diarrhoea, and abdominal pain. If you suspect an overdose, please consult your doctor immediately.

  • If you miss a dose of this medicine, consult your doctor for the next dose. However, if it is nearly time for your next dose, skip the missed dose and continue with your regular dosing schedule.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • Drinking plenty of water can help manage diarrhoea and nausea associated with this medication.

Use in Driving and Operating Machinery

  • It may cause drowsiness and dizziness. Avoid driving or operating heavy machinery while on this medication.

Use in Pregnancy and Lactation

  • The safety of Cefoperazone + Tazobactam during pregnancy and breastfeeding is not well established. Therefore, it is advised to consult your doctor before using this medicine if you are pregnant or breastfeeding.

Caution in Other Conditions

  • Patients with renal impairment should exercise caution when using this combination, as dosage adjustments may be necessary based on the creatinine clearance.

  • Those with a history of gastrointestinal diseases, particularly colitis, should use this medicine with caution.

Special Dietary and Lifestyle Recommendations

  • To prevent bacterial infections, maintain good hygiene practices such as regular hand washing.

  • Consuming a balanced diet rich in fruits, vegetables, lean proteins, and whole grains can support overall health and immune function.

Frequently asked questions

Cefoperazone + Tazobactam is not an over-the-counter medicine. It requires a prescription from a registered doctor to be purchased.

There is no direct link between using Cefoperazone + Tazobactam and experiencing sleep disturbances. However, if you feel excessively sleepy or restless after the medication, kindly consult your doctor.

Long-term use of any antibiotic, including Cefoperazone + Tazobactam, should be done under medical supervision as it can lead to resistance and reduce the effectiveness of the medication.

There are no known direct effects of Cefoperazone + Tazobactam on the menstrual cycle. However, if you observe any irregularities in your period, please consult your doctor.

Avoid consuming alcohol while on this medication as a disulfiram-like reaction characterised by flushing, sweating, and headache has been reported in some individuals.

Before starting any new supplement or remedy while on this medication, it is best to consult your doctor to avoid potential interactions.

The medication does not have any known effects on mood or energy levels. If you experience any mood changes or fatigue after starting this medication, please consult your doctor.

Terms & Conditions


Available medicines for CEFOPERAZONE + TAZOBACTAM
Cefxor Xp 1000/125 MG Injection 1
Cefxor Xp 1000/125 MG Injection 1
Trireme Life Sciences Pvt Ltd
Pack of 1 UNIT
â‚ą237.80
MRP â‚ą290.00
18.00% OFF
Lupitum 250/250 MG Injection 1
Lupitum 250/250 MG Injection 1
Lupin Ltd
Pack of 1 UNITS
â‚ą143.09
MRP â‚ą174.50
18.00% OFF
Grct 1000/125 MG Injection 1
Grct 1000/125 MG Injection 1
Zydus Cadila
Pack of 1 UNITS
â‚ą169.32
MRP â‚ą206.49
18.00% OFF
Cegava Tz 1000/125 MG Injection 1
Cegava Tz 1000/125 MG Injection 1
Biocon Ltd
Pack of 1 Units
â‚ą533.76
MRP â‚ą650.93
18.00% OFF
Kephazon Tz 1000/125mg Injection 1
Kephazon Tz 1000/125mg Injection 1
United Biotech (p) Ltd
Pack of 1 UNITS
â‚ą447.72
MRP â‚ą546.00
18.00% OFF
Lupitum 1gm/125mg Injection 1
Lupitum 1gm/125mg Injection 1
Lupin Ltd
Pack of 1 UNITS
â‚ą258.71
MRP â‚ą315.50
18.00% OFF
Hospitaz 1000/125 MG Injection 1
Hospitaz 1000/125 MG Injection 1
Alkem Laboratories Ltd.
Pack of 1 Units
â‚ą482.16
MRP â‚ą588.00
18.00% OFF
Lupitum 500/500 MG Injection 1
Lupitum 500/500 MG Injection 1
Lupin Ltd
Pack of 1 UNITS
â‚ą214.02
MRP â‚ą261.00
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