Agomelatine

Dosage Forms Available

• Agomelatine is available as tablets for oral administration.

Age and Dose Restrictions

• This medicine is recommended for the treatment of depressive episodes in adults only.

Contraindications

• Agomelatine is contraindicated in patients with known allergies to the medicine or any of its components.
• It should not be used by individuals who have hepatic impairment or active liver disease.

Other Medications to Avoid

• Agomelatine may interact with strong inhibitors of CYP1A2 enzyme (e.g., fluvoxamine and ciprofloxacin), and moderate inhibitors (e.g., estrogen-containing oral contraceptives and paroxetine).
• It is important to consult your doctor before starting any prescription or over-the-counter medications while taking Agomelatine.

Overdose and Missed Dose

• An overdose of Agomelatine can lead to an increase in its side effects, such as headache, dizziness, and somnolence. If you suspect an overdose, seek medical attention immediately.
• If you miss a dose, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take an extra dose to compensate for the missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• Drinking plenty of water can help reduce some side effects like dry mouth.
• Try taking the medication at bedtime if it causes drowsiness.
• Maintaining a regular sleep schedule can help manage sleep-related side effects.

Use in Driving and Operating Machinery

• Agomelatine may cause dizziness or somnolence. If you experience these side effects, refrain from driving or operating heavy machinery until you feel alert again.

Use in Pregnancy and Lactation

• Agomelatine is not recommended for use during pregnancy or lactation. Always consult your doctor before using this medication if you are pregnant, planning a pregnancy, or breastfeeding.

Caution in Other Conditions

• Agomelatine should be used with caution in elderly patients over 75 years of age due to limited data.
• Patients with a history of mania or hypomania should be cautious while taking Agomelatine as it may precipitate a manic episode.
• It should also be used with caution in patients with severe renal impairment or liver disease

Special Dietary and Lifestyle Recommendations

• Regular physical activity can help manage depressive symptoms and improve your mood.
• Aim to establish regular sleep patterns which can help regulate the body's circadian rhythm.
• Limit intake of caffeine and alcohol which can interfere with sleep and exacerbate depressive symptoms.
• Try to engage in stress-reducing activities such as yoga, meditation, or deep-breathing exercises.