Alfacalcidol

Dosage Forms Available

• Alfacalcidol can be given orally (capsule and oral drop) and intravenously (injection).

Age and Dose Restrictions

• Alfacalcidol can be used by both adults and children.

Contraindications

• Alfacalcidol is contraindicated in patients with hypercalcemia or evidence of vitamin D toxicity. It should be used cautiously in those with hyperphosphatemia or a history of kidney stones.

Other Medications to Avoid

• This medicine can interact with antacids containing magnesium (such as aluminium hydroxide and magnesium carbonate), anticonvulsants (such as phenytoin), thiazide diuretics (such as hydrochlorothiazide and chlorthalidone), and certain cholesterol-lowering medicines (like cholestyramine and colestipol).

Overdose and Missed Dose

• Overdose of Alfacalcidol can lead to symptoms like hypercalcemia, which is manifested as nausea, vomiting, loss of appetite, dry mouth, constipation or diarrhoea. If these symptoms occur, seek immediate medical attention.

• If a dose is missed, take the missed dose as soon as you remember. But if it is almost time for the next dose, skip the missed dose. Do not double up the dose to catch up. If you miss a dose of injectable Alfacalcidol, contact your doctor for instructions.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• Drinking plenty of fluids can help manage nausea and vomiting.

• For constipation, try to eat fibre-rich foods and maintain a regular eating schedule.

• Ensure to rest and relax if you're feeling fatigued or weak.

Use in Driving and Operating Machinery

• Alfacalcidol can sometimes cause fatigue or muscle weakness. Therefore, it may affect your ability to drive or operate heavy machinery. Avoid such activities if you feel dizzy or weak after taking this medication.

Use in Pregnancy and Lactation

• Alfacalcidol should only be used in pregnancy if clearly needed, as it can pass into the breast milk. Therefore, caution is advised during breastfeeding.

Caution in Other Conditions

• Frequent monitoring of serum calcium, phosphate, and kidney function is necessary during treatment with Alfacalcidol. Patients with impaired kidney or liver function may require lower doses. Also, prolonged immobilisation can lead to hypercalcemia, so the dose may need to be reduced temporarily in such cases.

Special Dietary and Lifestyle Recommendations

• Regular check-ups with your doctor to monitor vitamin D levels are recommended.