Amikacin + Cefepime
Uses of Amikacin + Cefepime
Amikacin + Cefepime is primarily used to manage serious bacterial infections. This combination belongs to antibiotic medications.
Secondary uses of this medicine include management of hospital-acquired pneumonia, ventilator-associated pneumonia, complicated intra-abdominal infections (with metronidazole), complicated urinary tract infections, and empiric therapy for febrile neutropenia.
Side effects of Amikacin + Cefepime
Nephrotoxicity
Ototoxicity (auditory and vestibular)
Neuromuscular blockade
Nausea
Skin rash
How Amikacin + Cefepime works
Amikacin belongs to the aminoglycoside antibiotics class of medicines that works by binding to the 30S ribosomal subunit of specific bacteria. This binding disrupts protein synthesis, an essential process for bacterial survival and reproduction, ultimately halting bacterial growth.
Cefepime is a fourth-generation cephalosporin antibiotic, that functions by inhibiting the formation of bacterial cell walls. It does this by blocking penicillin-binding proteins, which are crucial for linking peptidoglycan strands in the cell wall. Without this connection, the cell wall becomes weakened, leading to bacterial cell destruction.
Certified content
Written By
BDS, MDS
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Amikacin + Cefepime is available primarily in the form of injection.
It is typically administered through intramuscular (IM) or intravenous (IV) routes.
Age and Dose Restrictions
This medicine is meant for use in adults and children.
Contraindications
Amikacin + Cefepime is contraindicated in patients with known hypersensitivity to either amikacin, cefepime, or any other aminoglycosides and cephalosporins.
Other Medications to Avoid
This medicine may interact with other aminoglycosides (e.g., gentamicin), antibiotics (e.g., vancomycin), diuretics (e.g., furosemide), neuromuscular blockers (e.g., succinylcholine), and anticoagulants (e.g., warfarin).
Overdose and Missed Dose
Chances for overdose are less as it is administered to you by a healthcare professional. However, an overdose of Amikacin + Cefepime may lead to complications like kidney damage, hearing loss, confusion, or severe allergic reactions. If you suspect an overdose, it is important to seek immediate medical attention.
If you miss a dose of this medicine, consult your healthcare provider for the next dose.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Adjusting the time of medication administration may help manage nausea or sleep disturbances.
Drinking adequate water can help mitigate potential kidney-related side effects by keeping you well-hydrated.
Use in Driving and Operating Machinery
Amikacin + Cefepime may cause dizziness or confusion especially at higher doses or due to its potential CNS effects. Consider avoiding driving or operating heavy machinery if these symptoms occur.
Use in Pregnancy and Lactation
This medicine is not recommended during pregnancy and breastfeeding unless specifically advised by a healthcare professional. Consult a doctor before taking this medicine during these periods.
Caution in Other Conditions
Patients with pre-existing kidney problems or hearing issues should exercise caution while administering this medicine due to its potential nephrotoxic and ototoxic effects.
Regular monitoring of kidney function and hearing levels is recommended for patients on this medication.
Special Dietary and Lifestyle Recommendations
Ensure adequate hydration to support kidney health while using Amikacin + Cefepime.
Limit exposure to loud noises to prevent exacerbation of potential hearing impairment from amikacin.
Monitor salt intake as excessive sodium can affect blood pressure, influencing kidney stress.
Consuming a balanced diet rich in fruits, vegetables, and lean proteins can support overall health thus aiding recovery from infections treated by this antibiotic combination.
Manage stress through mild to moderate exercise such as walking or yoga which may also enhance immune system function.
Frequently asked questions
Is Amikacin + Cefepime a steroid?
No, Amikacin + Cefepime is not a steroid. It is a combination of two antibiotics: Amikacin, which belongs to the aminoglycoside class, and Cefepime, which is a cephalosporin.
Does Amikacin + Cefepime affect sleep?
There is no direct evidence or report suggesting that Amikacin + Cefepime has any impact on sleep. However, if you experience any unusual sleep patterns after administration, consult your doctor.
Will Amikacin + Cefepime affect fertility?
There is no recorded data indicating that Amikacin + Cefepime affects fertility in humans. If you have concerns about fertility, it is recommended you discuss them with your doctor.
Are there any particular diet restrictions while taking Amikacin + Cefepime?
There are no specific diet restrictions while taking Amikacin + Cefepime, unless specified by your doctor. As with any medication, a balanced diet and adequate hydration are recommended for general health.
Is it safe to take Amikacin + Cefepime daily?
Amikacin + Cefepime should be taken as prescribed by your doctor, who will determine the dosage and duration of treatment based on your condition and response to therapy.
How much time does Amikacin + Cefepime take to work?
The action of Amikacin + Cefepime begins quite soon after administration but the time taken to show its effect can vary depending on the type and severity of the infection.
What is the best time to take Amikacin + Cefepime?
Amikacin + Cefepime can be taken at any time of the day as directed by your doctor. It is generally recommended to take it at the same time each day for better efficacy.
Amikacin + Cefepime in other salts
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