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Amitriptyline + Gabapentin

Uses of Amitriptyline + Gabapentin

  • Amitriptyline + Gabapentin is primarily used for the management of various neuropathic pain conditions. It belongs to the class of tricyclic antidepressants and anticonvulsants

  • These conditions may include diabetic neuropathy (nerve damage caused by high blood sugar levels), postherpetic neuralgia (pain lingering after a shingles infection), fibromyalgia (widespread musculoskeletal pain), and other nerve-related pain conditions

Side effects of Amitriptyline + Gabapentin

  • Drowsiness

  • Dizziness

  • Dry mouth

  • Constipation

  • Weight gain

How Amitriptyline + Gabapentin works

Amitriptyline + Gabapentin is a combination medication composed of a tricyclic antidepressant and an anticonvulsant. Amitriptyline and Gabapentin work in harmony to manage nerve pain through multiple mechanisms, complementing each other's activity for an amplified effect.

  • Amitriptyline works by increasing the levels of certain neurotransmitters, namely serotonin and norepinephrine, in the brain. These chemical messengers help improve mood and alleviate pain

  • Gabapentin is an anticonvulsant that possesses properties to relieve pain. It is understood to modulate calcium channels on nerves to reduce the transmission of pain signals. However, its exact mechanism in managing neuropathic pain is not fully understood

Certified content

Written By

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Dr. Michelle FrankMedical Content Writer| 8 years

Doctor of Medicine

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Amitriptyline + Gabapentin is available as tablets and capsules for oral administration

Age and Dose Restrictions

  • This combination is intended for use in adults and children above the age of 12 years

Contraindications

  • Patients with known hypersensitivity to either amitriptyline or gabapentin should not use this medication

  • It is also contraindicated in cases of recent myocardial infarction, arrhythmias, and severe liver disease

Other Medications to Avoid

  • Amitriptyline + Gabapentin can interact with opioids (such as morphine, fentanyl, and tramadol), benzodiazepines (like alprazolam, diazepam), antihistamines (like cetirizine, and diphenhydramine), SSRIs (such as escitalopram, fluoxetine), SNRIs (like duloxetine, venlafaxine), MAO inhibitors (like phenelzine and tranylcypromine)

Overdose and Missed Dose

  • In case of an overdose of Amitriptyline + Gabapentin, symptoms may include extreme drowsiness, confusion, seizures, cardiac disturbances, and respiratory depression. Immediate medical attention should be sought

  • If a dose of this medicine is missed, it should be taken as soon as the patient remembers. However, if it is almost time for the next dose, then the missed dose should be skipped

Management of Side Effects

  • Most side effects are temporary and generally harmless, They resolve upon discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor

  • Drinking plenty of water can help manage side effects like dry mouth and constipation

  • Standing up slowly from a sitting or lying can help manage dizziness and lightheadedness

Use in Driving and Operating Machinery

  • Amitriptyline + Gabapentin can cause drowsiness and impair the ability to concentrate. Therefore, it is advised to avoid driving or operating heavy machinery until a clear understanding of its effects is established

Use in Pregnancy and Lactation

  • The use of Amitriptyline + Gabapentin during pregnancy and lactation should only be considered if the benefits outweigh the risks

  • It is important to consult your doctor before using this medicine if you are pregnant or breastfeeding

Caution in Other Conditions

  • Caution is advised when using Amitriptyline + Gabapentin in patients with seizure disorders, suicidal tendencies, urinary retention, and angle-closure glaucoma

  • Dose adjustments may be necessary for individuals with kidney or liver diseases

Special Dietary and Lifestyle Recommendations

  • Patients suffering from neuropathic pain conditions are advised to maintain a balanced diet rich in fruits, vegetables, whole grains, and lean proteins

  • Regular physical activity is also recommended to keep the body fit and promote overall health

  • Stress management techniques such as yoga, mindfulness meditation, or deep-breathing exercises may also be beneficial

  • Avoid alcohol consumption as it may exacerbate certain side effects such as drowsiness or dizziness associated with this medication

Frequently asked questions

Amitriptyline + Gabapentin is not available as an over-the-counter medication. It requires a prescription from your doctor.

Yes, Amitriptyline + Gabapentin can potentially cause mood changes. Some people may experience depression or other neuropsychiatric symptoms. It is crucial to monitor any mood changes while on this medication.

Amitriptyline + Gabapentin should be used with caution in patients with severe liver disease, as it might exacerbate the condition. It is always best to consult your doctor before starting any new medication.

No, it is not advisable to abruptly stop taking Amitriptyline + Gabapentin as it may lead to withdrawal symptoms such as nausea, headache, and malaise. The dosage should be gradually tapered down under the supervision of a doctor.

The combination of Amitriptyline and Gabapentin may lead to weight gain in some individuals, which could be related to changes in appetite. However, everyone's response may vary, so it is best to discuss any concerns with your doctor.

Overdosing on Amitriptyline and Gabapentin can cause extreme drowsiness, confusion, seizures, cardiac disturbances, and respiratory depression. Overdosage requires immediate medical attention to prevent serious complications.

There may be some natural or alternative treatments that can help manage neuropathic pain. However, it is important to understand that these may not be as effective or as well-researched as Amitriptyline + Gabapentin. Always consult your doctor before starting any new treatment regimen.

Terms & Conditions


Available medicines for AMITRIPTYLINE + GABAPENTIN
Adgaba At 300/10 MG Tablet 10
Adgaba At 300/10 MG Tablet 10
Bion Thearapeutics
Pack of 10 Units
₹97.58
MRP ₹119.00
18.00% OFF
Laregab At Ls 100/10 MG Tablet 10
Laregab At Ls 100/10 MG Tablet 10
La Renon
Pack of 10 Units
₹63.14
MRP ₹77.00
18.00% OFF
Gabantip At 100/10 MG Tablet 10
Gabantip At 100/10 MG Tablet 10
Unimed Technologies Limited
Pack of 10 Units
₹65.60
MRP ₹80.00
18.00% OFF
Amigaba 300/10 MG Tablet 10
Amigaba 300/10 MG Tablet 10
Icon Lifesciences
Pack of 10 Units
₹132.84
MRP ₹162.00
18.00% OFF
Amigatin 300/10 MG Tablet 10
Amigatin 300/10 MG Tablet 10
Crescent Formulations Pvt. Ltd.
Pack of 10 Units
₹125.73
MRP ₹153.33
18.00% OFF
Amigatin Ls Tablet 10
Amigatin Ls Tablet 10
Crescent Formulations Pvt. Ltd.
Pack of 10 Units
₹62.87
MRP ₹76.67
18.00% OFF
Amigaba Ls Tablet 10
Amigaba Ls Tablet 10
Icon Lifesciences
Pack of 10 Units
₹62.73
MRP ₹76.50
18.00% OFF

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