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Amitriptyline + Methylcobalamin

Uses of Amitriptyline + Methylcobalamin

  • Amitriptyline + Methylcobalamin is used to manage symptoms of depression, as it belongs to the group of tricyclic antidepressants and vitamin B12 compounds. 
  • This combination is also beneficial for managing conditions such as anxiety, neuropathic pain, insomnia, and chronic pain syndromes like fibromyalgia.
  • Additionally, Clonazepam + Propranolol is used to treat anxiety and is effective for managing high blood pressure, panic disorder, seizure disorder, fast heartbeat, and migraines.

Side effects of Amitriptyline + Methylcobalamin

  • Drowsiness

  • Dizziness

  • Dry mouth

  • Increased appetite

  • Nausea

How Amitriptyline + Methylcobalamin works

  • Amitriptyline, a tricyclic antidepressant, works by increasing the levels of certain chemicals in the brain that help regulate mood, sleep, and pain perception.

  • Methylcobalamin, the activated form of vitamin B12, supports healthy nerve signaling. It aids in the formation of a protective covering around nerve fibers, essential for proper brain and nerve functioning.

  • Together, these components work to balance chemical levels in the brain and support nerve health. This helps manage conditions like depression and neuropathic pain effectively.

Certified content

Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Osama Ahmed
Dr. Osama Ahmed Dental/Medical Writer, Editor, Reviewer| 2 years

Bachelor of Dental Surgery

Expert Advice

Dosage Forms Available

  • Amitriptyline + Methylcobalamin is available for use via the oral route in the form of tablets.

Age and Dose Restrictions

  • This medicine is meant for adults and is not typically prescribed for children. It is essential to adhere to a doctor's guidance regarding age suitability.

Contraindications

  • This medicine is contraindicated in patients with known allergies to amitriptyline or methylcobalamin.

  • It should not be used by those with heart issues such as irregular heartbeat, recent heart attack, or severely low blood pressure.

  • Patients with urinary retention or uncontrolled narrow-angle glaucoma should also avoid using this medication.

Other Medications to Avoid

  • This combination may interact with monoamine oxidase inhibitors (such as selegiline and phenelzine), other antidepressants (like fluoxetine and venlafaxine), anticholinergics (including atropine and scopolamine), thyroid medications (such as levothyroxine), and anticoagulants (like warfarin).

Overdose and Missed Dose

  • An overdose of Amitriptyline + Methylcobalamin may lead to severe drowsiness, confusion, difficulty breathing, and convulsions. Immediate medical attention is required if an overdose is suspected.

  • If you miss a dose of this medication, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a forgotten one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • To manage dry mouth, sip water regularly or use sugar-free gum to stimulate saliva production.

  • If experiencing constipation, consider increasing dietary fiber intake or ensuring adequate hydration.

  • For drowsiness, try taking the medicine at bedtime to minimize daytime sleepiness.

Use in Driving and Operating Machinery

  • This medication may affect your ability to drive or operate heavy machinery. Avoid engaging in these activities if you feel drowsy or dizzy after taking this medicine.

Use in Pregnancy and Lactation

  • Amitriptyline + Methylcobalamin is generally not recommended during pregnancy and breastfeeding. If you are pregnant or planning to become pregnant, consult your doctor before starting this medication.

Caution in Other Conditions

  • Patients with liver or kidney disease should use Amitriptyline + Methylcobalamin with caution due to the increased risk of side effects.

  • Those with a history of seizures should also be cautious, as this medication can lower the seizure threshold.

Special Dietary and Lifestyle Recommendations

  • Maintain a balanced diet rich in vitamins, particularly B vitamins, to support nerve health while managing conditions like neuropathic pain or depression.

  • Engage in regular physical activity, which can help improve mood and reduce symptoms of depression.

  • Ensure adequate hydration, especially if experiencing side effects such as dry mouth or constipation.

  • Establish a regular sleep schedule to help improve sleep disturbances that might be associated with depression or anxiety.

Frequently asked questions

No, Amitriptyline + Methylcobalamin is not a steroid; it is a combination of tricyclic antidepressants and vitamin supplements.

While Amitriptyline + Methylcobalamin does not have any known specific food interactions, it is always wise to discuss your diet and lifestyle with your doctor while taking any medication.

The safety of long-term use of Amitriptyline + Methylcobalamin depends on individual health conditions and response to the medication. It is important to follow your doctor's instructions and regularly monitor your health during the treatment.

It is recommended to discuss with your doctor before taking any over-the-counter vitamins or supplements along with Amitriptyline + Methylcobalamin, as there can be potential interactions.

No, Amitriptyline + Methylcobalamin is not directly associated with weight gain, although it causes an increased appetite.

If you miss a dose of Amitriptyline + Methylcobalamin, take it as soon as you remember. However, if it is near the time of your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Amitriptyline + Methylcobalamin is typically suitable for vegetarians and vegans. However, it is always best to check the product label or consult with your doctor or pharmacist to ensure this medication meets your dietary requirements.

Terms & Conditions


Amitriptyline + Methylcobalamin in other salts

ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE) + VITAMIN D3 (CHOLECALCIFEROL)ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEASCORBIC ACID + BIOTIN + CALCIUM PANTOTHENATE + FOLIC ACID + METHYLCOBALAMIN + NIACINAMIDE + RIBOFLAVIN + THIAMINE MONONITRATE + ZINC SULPHATEELEMENTAL CALCIUM + L-METHYLFOLATE CALCIUM + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATE + VITAMIN D3 (CHOLECALCIFEROL)METHYLCOBALAMIN + PREGABALINMETHYLCOBALAMINAMITRIPTYLINEL METHYL FOLATE + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATEPREGABALIN + NORTRIPTYLINE + METHYLCOBALAMINGABAPENTIN + METHYLCOBALAMINALFACALCIDOL + DOCOSAHEXAENOIC ACID + EICOSAPENTAENOIC ACID + ELEMENTAL BORON + ELEMENTAL CALCIUM + FOLIC ACID + METHYLCOBALAMINMETHYLCOBALAMIN + THIOCTIC ACIDAMITRIPTYLINE + CHLORDIAZEPOXIDEL METHYLFOLATE + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATEALPHA LIPOIC ACID + BENFOTIAMINE + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEBORON + CALCITRIOL/ CHOLECALCIFEROL + CALCIUM CARBONATE + DOCOSAHEXAENOIC ACID + EICOSAPENTAENOIC ACID + FOLIC ACID + METHYLCOBALAMINDHA + L-METHYLFOLATE + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEDOCOSAHEXAENOIC ACID + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEFOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + BENFOTIAMINE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + PREGABALIN + VITAMIN B6 / PYRIDOXINEDULOXETINE + METHYLCOBALAMINALPHA LIPOIC ACID + BENFOTIAMINE + ELEMENTAL CHROMIUM + INOSITOL + METHYLCOBALAMINDHA + L-METHYLFOLATE + METHYLCOBALAMINALPHA LIPOIC ACID + BENFOTIAMINE + INOSITOL + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEDOCOSAHEXAENOIC ACID + L METHYLFOLATE + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATEL-METHYLFOLATE + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + METHYLCOBALAMIN + PREGABALINALPHA LIPOIC ACID + GABAPENTIN + METHYLCOBALAMINBENFOTIAMINE + FOLIC ACID + METHYLCOBALAMIN + PREGABALIN + VITAMIN B6 / PYRIDOXINEFOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + BENFOTIAMINE + BIOTIN + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + THIAMINE MONONITRATE + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + METHYLCOBALAMINALPHA LIPOIC ACID + BIOTIN + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + BENFOTIAMINE + BIOTIN + ELEMENTAL CHROMIUM + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + CHROMIUM PICOLINATE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + SELENOMETHIONINE + ZINC MONOMETHIONINEALPHA LIPOIC ACID + BENFOTIAMINE + CHROMIUM PICOLINATE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + BENFOTIAMINE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEFOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINE + VITAMIN D3 (CHOLECALCIFEROL)ALPHA LIPOIC ACID + BENFOTIAMINE + CHROMIUM POLYNICOTINATE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + SELENIUM DIOXIDEFOLIC ACID + METHYLCOBALAMINALPHA LIPOIC ACID + BENFOTIAMINE + BIOTIN + CHROMIUM PICOLINATE + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + CHROMIUM PICOLINATE + METHYLCOBALAMIN + OMEGA 3 FATTY ACID + SELENIUM DIOXIDEALPHA LIPOIC ACID + BENFOTIAMINE + CHROMIUM PICOLINATE + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + BENFOTIAMINE + CHROMIUM PICOLINATE + FOLIC ACID + METHYLCOBALAMIN + MYO INOSITOL + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + PREGABALIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINE + VITAMIN D3 (CHOLECALCIFEROL)DOCOSAHEXAENOIC ACID + L METHYLFOLATE + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATE + VITAMIN D3 (CHOLECALCIFEROL)FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE) + VITAMIN D3 (CHOLECALCIFEROL)CITICOLINE + METHYLCOBALAMINELEMENTAL IRON + ELEMENTAL ZINC + FOLIC ACID + METHYLCOBALAMINBORON + CALCITRIOL/ CHOLECALCIFEROL + CALCIUM CARBONATE + DHA / DOCOSAHEXAENOIC ACID + EPA / EICOSAPENTAENOIC ACID + FOLIC ACID + METHYLCOBALAMINALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + PYRIDOXINE HYDROCHLORIDE + THIAMINE MONONITRATEBENFOTIAMINE + FOLIC ACID + METHYLCOBALAMIN + PREGABALIN + VITAMIN B6 (PYRIDOXINE)AMITRIPTYLINE + PREGABALINCALCITRIOL/ CHOLECALCIFEROL + CALCIUM CARBONATE + L METHYLFOLATE + MAGNESIUM + METHYLCOBALAMIN + VITAMIN K27 + ZINCDHA / DOCOSAHEXAENOIC ACID + L METHYLFOLATE + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATE + VITAMIN D3 (CHOLECALCIFEROL)ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + PYRIDOXINE HYDROCHLORIDE + VITAMIN D3 (CHOLECALCIFEROL)ELEMENTAL IRON + FOLIC ACID + METHYLCOBALAMINMETHYLCOBALAMIN + NICOTINAMIDE + VITAMIN B6 / PYRIDOXINEFOLIC ACID + METHYLCOBALAMIN + NIACINAMIDE + VITAMIN C / ASCORBIC ACIDD-PANTHENOL + METHYLCOBALAMIN + NIACINAMIDE + VITAMIN B6 / PYRIDOXINEFOLIC ACID + METHYLCOBALAMIN + NIACINAMIDEMETHYLCOBALAMIN + NIACINAMIDE + VITAMIN B6 / PYRIDOXINEFOLIC ACID + METHYLCOBALAMIN + NIACINAMIDE + VITAMIN B6 / PYRIDOXINEMETHYLCOBALAMIN + NICOTINAMIDE + VITAMIN B6 (PYRIDOXINE)D-PANTHENOL + METHYLCOBALAMIN + NIACINAMIDE + VITAMIN B6 (PYRIDOXINE)FERROUS ASCORBATE + FOLIC ACID + METHYLCOBALAMINAMITRIPTYLINE + GABAPENTINEPALRESTAT + METHYLCOBALAMINFOLIC ACID + L-CARNITINE / LEVOCARNITINE + METHYLCOBALAMINMETFORMIN + METHYLCOBALAMINCALCIUM-5 METHYLTETRAHYDROFOLATE + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATEALPHA LIPOIC ACID + BENFOTIAMINE + CALCIUM CARBONATE + CHROMIUM PICOLINATE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINE + VITAMIN D3 (CHOLECALCIFEROL)D CHIRO INOSITOL + L-METHYLFOLATE + METFORMIN + METHYLCOBALAMIN + MYO INOSITOLFOLIC ACID + METHYLCOBALAMIN + PREGABALIN + VITAMIN B6 / PYRIDOXINEL-METHYLFOLATE CALCIUM + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATEFERROUS BISGLYCINATE + FOLIC ACID + METHYLCOBALAMIN + ZINC BISGLYCINATEFOLIC ACID + METHYLCOBALAMIN + PYRIDOXINE HYDROCHLORIDEADENOSYLCOBALAMIN + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B1 + VITAMIN B2 + VITAMIN B6 (PYRIDOXINE)DIACEREIN + GLUCOSAMINE SULFATE POTASSIUM CHLORIDE + METHYL SULFONYL METHANE + METHYLCOBALAMINBORON + CALCITRIOL/ CHOLECALCIFEROL + CALCIUM CARBONATE + FOLIC ACID + METHYLCOBALAMIN + OMEGA 3 FATTY ACIDALPHA LIPOIC ACID + BENFOTIAMINE + CALCIUM CARBONATE + CHROMIUM PICOLINATE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + PYRIDOXINE HYDROCHLORIDE + VITAMIN D3 (CHOLECALCIFEROL)ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + THIAMINE + VITAMIN B6 / PYRIDOXINE
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