Amlodipine + Nebivolol

Dosage Forms Available

• Amlodipine + Nebivolol is available in tablet form for oral administration.

Age and Dose Restrictions

• This combination is intended for use by adults only.

Contraindications

• This combination is contraindicated in patients with severe bradycardia.

• It is also contraindicated in individuals with heart block greater than first degree, cardiogenic shock, or decompensated heart failure.

• Patients with severe hepatic impairment and sick sinus syndrome (without a pacemaker) should avoid this combination.

Other Medications to Avoid

• This combination may interact with CYP3A4 inhibitors (such as diltiazem and ketoconazole), CYP2D6 inhibitors (such as quinidine and fluoxetine), other antihypertensives (like lisinopril and candesartan), NSAIDs (like ibuprofen, naproxen), and medications like digoxin (a cardiac glycoside), clonidine (acentrally acting alpha-agonist hypotensive agent), and insulin or oral hypoglycaemics (like glipizide).

Overdose and Missed Dose

• An overdose of might cause excessive peripheral vasodilation, bradycardia, hypotension, and potential cardiogenic shock. Immediate medical intervention is crucial.

• If you miss a dose of this combination, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose. Do not take a double dose to make up for the missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this combination. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• If dizziness occurs, try lying down until the sensation passes and then rise slowly to a sitting position before standing.

• Staying well hydrated may help alleviate some side effects such as headaches and dry mouth.

Use in Driving and Operating Machinery

• Amlodipine + Nebivolol may cause side effects such as dizziness or lightheadedness, which could affect your ability to drive or operate heavy machinery. It is advisable to avoid these activities if you do not feel alert.

Use in Pregnancy and Lactation

• Amlodipine + Nebivolol may cause harm to the foetus and is not recommended during pregnancy or lactation. If you are pregnant or breastfeeding, consulting your doctor before using this medicine is crucial.

Caution in Other Conditions

• Individuals with severe renal impairment or mild-to-moderate hepatic impairment should be cautious while using this combination. The prescribing doctor may need to adjust the dose accordingly.

Special Dietary and Lifestyle Recommendations

• Regular physical activity like walking, cycling or swimming can help lower blood pressure. Aim for at least 150 minutes of moderate aerobic activity or 75 minutes of vigorous activity each week.

• Monitoring your blood pressure at home can help you keep track of your health status effectively.

• Maintain a low-sodium diet to help manage hypertension effectively.