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Amoxicillin + Bromhexine

Uses of Amoxicillin + Bromhexine

  • Amoxicillin + Bromhexine is primarily used to manage respiratory tract infections, specifically ones that involve excessive, viscous mucus production. It belongs to the class of penicillin antibiotics and mucolytic agents.
  • Amoxycillin + Bromhexine is a combination of two medicines: Amoxycillin and Bromhexine which treat respiratory tract infections associated with excessive mucus (phlegm).

Side effects of Amoxicillin + Bromhexine

  • Diarrhoea

  • Nausea

  • Vomiting

  • Skin rashes

  • Oral thrush (fungal infection)

How Amoxicillin + Bromhexine works

  • Amoxicillin + Bromhexine is an antibacterial and mucolytic combination.

  • Amoxicillin is a penicillin-type antibiotic. It works by blocking the growth of bacteria. It does this by attaching to and inactivating proteins (penicillin-binding proteins) located within the bacteria's cell walls. This prevents the essential cross-linking of peptidoglycan chains that maintain the strength and rigidity of the bacterial cell wall, causing it to weaken and eventually rupture due to osmotic pressure.

  • Bromhexine is a mucolytic agent. It thins and loosens mucus in the airways, making it easier to cough out. It does this by directly breaking down mucopolysaccharides and by releasing lysosomal enzymes, which alter the structure of the mucus. As a result, mucus becomes less sticky and less viscous, making it easier for ciliary action and coughing to clear it. In addition, Bromhexine increases the frequency of cilia movement, enhancing mucus transport.

  • Together, these components effectively manage bacterial respiratory infections accompanied by excessive mucus production.

Certified content

Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Divya Chauhan
Dr. Divya Chauhan Medical Writer & Reviewer| 6 years

BAMS, APG, PG

Expert Advice

Dosage Forms Available

  • Amoxicillin + Bromhexine is available for oral administration in the form of tablets, oral suspensions, and sachets.

Age and Dose Restrictions

  • This combination is suitable for both adults and children. The specific age at which children can begin taking this combination varies based on the formulation and should be confirmed with a doctor.

Contraindications

  • Amoxicillin + Bromhexine is contraindicated in individuals allergic to penicillins or cephalosporins, with liver dysfunction, with cholestatic jaundice from amoxicillin, or with infectious mononucleosis owing to an increased rash risk.

Other Medications to Avoid

  • Amoxicillin + Bromhexine may interact with antigout medicines (like probenecid, probalan), xanthine oxidase inhibitors (like allopurinol), anticoagulants (like warfarin) and antimetabolites (like methotrexate).

Overdose and Missed Dose

  • Overdosing can lead to severe nausea, vomiting, diarrhoea, skin rash, and kidney problems. If you suspect an overdose, seek medical attention immediately.

  • If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and resume your dosing schedule. Do not double the dose to catch up.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this combination. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • Drinking plenty of fluids can help alleviate some of the gastrointestinal side effects, like diarrhoea and nausea.

  • For mild diarrhoea or stomach upset, consider taking the combination with food or adjusting the timing slightly.

Use in Driving and Operating Machinery

  • This combination may cause dizziness, confusion, and blurred vision, which might affect your ability to drive or operate heavy machinery. You should avoid these activities if you experience these side effects.

Use in Pregnancy and Lactation

  • Amoxicillin + Bromhexine should only be used during pregnancy or while breastfeeding if deemed necessary by a doctor. It is important to discuss all potential risks and benefits with your doctor if you are pregnant or breastfeeding.

Caution in Other Conditions

  • Patients with kidney disease may need dose adjustments when using this combination owing to its excretion paths.

  • Those with a history of gastric ulcers or bleeding should use this combination cautiously, as Bromhexine may aggravate these conditions.

Special Dietary and Lifestyle Recommendations

  • Drink at least 8-10 glasses of water daily to help keep mucus thin and improve the effectiveness of Bromhexine.

  • High-fat foods can slow down the absorption of Amoxicillin. Opt for a diet with moderate fat content to ensure proper absorption.

  • Avoid smoking and exposure to pollutants; these can exacerbate respiratory conditions.

Frequently asked questions

No, it is not a steroid. This combination consists of an antibiotic (Amoxicillin) and a mucolytic agent (Bromhexine).

No, it is not known to have any direct effect on sleep. However, if you experience sleep disturbances after taking this combination, you should consult your doctor.

It is not known to directly affect fertility. However, if you are planning to conceive and have concerns, it is recommended to discuss this with your doctor.

No, there is no evidence that Amoxicillin + Bromhexine is habit-forming or addictive.

The safety of taking this combination daily depends on the nature and severity of your condition, as well as your overall health status. The combination should be taken according to the dosage and duration prescribed by your doctor.

Symptom relief may be noticed within 1 to 2 days. However, the full course of the combination should be completed even if symptoms improve earlier to ensure complete eradication of the infection.

The exact timing for taking it would depend on your doctor's instructions and it will be prescribed by your doctor.

Terms & Conditions


Amoxicillin + Bromhexine in other salts

AMOXICILLIN + CLAVULANIC ACIDTERBUTALINE + BROMHEXINEAMOXICILLIN + DICLOXACILLINAMOXICILLIN + CLOXACILLINAMOXICILLINAMOXICILLIN + LACTOBACILLUSAMOXICILLIN + CLOXACILLIN + LACTOBACILLUSAMOXICILLIN + CLOXACILLIN + SERRATIOPEPTIDASEAMOXICILLIN + DICLOXACILLIN + LACTOBACILLUSBROMHEXINE + GUAIFENESIN + TERBUTALINEAMOXICILLIN + CARBOCISTEINEAMOXICILLIN + DICLOXACILLIN + LACTIC ACID BACILLUSAMOXICILLIN + CLOXACILLIN + LACTOBACILLUS + SERRATIOPEPTIDASEAMOXICILLIN + CLAVULANIC ACID + LACTOBACILLUSAMOXICILLIN + OMEPRAZOLE + TINIDAZOLEAMOXICILLIN + CLARITHROMYCIN + PANTOPRAZOLEAMOXICILLIN + CLARITHROMYCIN + ESOMEPRAZOLEAMMONIUM CHLORIDE + BROMHEXINE + DEXTROMETHORPHAN HYDROBROMIDEBROMHEXINE + GUAIFENESIN + MENTHOL + TERBUTALINEAMOXICILLIN + POTASSIUM CLAVULANATE / CLAVULANIC ACIDBROMHEXINEBROMHEXINE + GUAIFENESIN + SALBUTAMOLBROMHEXINE + SALBUTAMOLBROMHEXINE + GUAIFENESIN + PHENYLEPHRINEBROMHEXINE + PHENYLEPHRINE + SALBUTAMOLBROMHEXINE + CHLORPHENIRAMINE MALEATE + GUAIFENESINBROMHEXINE + GUAIFENESIN + MENTHOL + SALBUTAMOLAMMONIUM CHLORIDE + BROMHEXINE + DEXTROMETHORPHAN HYDROBROMIDE + MENTHOLAMOXICILLIN + SULBACTAMBROMHEXINE + GUAIFENESINAMBROXOL + AMOXICILLINBROMHEXINE + CHLORPHENIRAMINE + DEXTROMETHORPHANBROMHEXINE + PSEUDOEPHEDRINEAMMONIUM CHLORIDE + BROMHEXINE + DEXTROMETHORPHANBROMHEXINE + ETOFYLLINE / ETOPHYLLINE + SALBUTAMOLBROMHEXINE + CHLORPHENIRAMINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINEAMMONIUM CHLORIDE + BROMHEXINE + DEXTROMETHORPHAN + MENTHOLBROMHEXINE + DEXTROMETHORPHAN + PHENYLEPHRINEBROMHEXINE + CHLORPHENIRAMINE MALEATE + DEXTROMETHORPHAN HYDROBROMIDE + GUAIFENESINBROMHEXINE + CPM + GUAIFENESIN + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINEBROMHEXINE + CHLORPHENIRAMINE MALEATE + GUAIFENESIN + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINEAMOXICILLIN + CLAVULANIC ACID + LACTIC ACID BACILLUSAMOXICILLIN + CLAVULANIC ACID + LACTOBACILLUS ACIDOPHILUS
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