Aprotinin

Dosage Forms Available

• Aprotinin is available as an injectable solution.

• The route of administration for Aprotinin is intravenous, meaning it is administered directly into the bloodstream.

Age and Dose Restrictions

• Aprotinin is approved for use in adults, particularly those undergoing complex surgeries such as heart surgery.

Contraindications

• Aprotinin is contraindicated in patients with a known hypersensitivity to any of its components.

• It should not be used by individuals with severe renal impairment or renal failure.

• Patients allergic to bovine (cow) products should not receive this medication.

Other Medications to Avoid

• Aprotinin can interact with anticoagulants (such as warfarin, heparin), other antifibrinolytics (such as tranexamic acid, epsilon-aminocaproic acid), and thrombolytics (such as streptokinase, alteplase). It may also interact with certain antibiotics (such as penicillin, cephalosporins) and medications affecting blood pressure (such as atenolol).

Overdose and Missed Dose

• An overdose of Aprotinin may lead to excessive blood clotting, which can result in complications such as stroke or heart attack. Immediate medical attention should be sought if an overdose is suspected.

• If a dose of this medicine is missed during scheduled surgical procedures, the medical team should be alerted immediately to address the dosing schedule appropriately.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• If experiencing nausea or vomiting, try taking the medication with a small amount of food or water if advised so by your doctor.

• For feelings of warmth or flushing, resting in a cool environment may provide relief.

Use in Driving and Operating Machinery

• Aprotinin does not directly impact the ability to drive or operate heavy machinery. However, considering it is used during surgical procedures under general anaesthesia, operating machinery or driving immediately following surgery is not advisable.

Use in Pregnancy and Lactation

• The safety of Aprotinin during pregnancy and breastfeeding has not been established. It is crucial to consult your doctor before receiving Aprotinin if you are pregnant or breastfeeding.

Caution in Other Conditions

• Individuals with a history of thrombotic events should use Aprotinin with caution due to an increased risk of further thrombotic complications.

• Patients previously exposed to Aprotinin should also exercise caution due to the potential for hypersensitivity reactions upon re-exposure.

Special Dietary and Lifestyle Recommendations

• Maintain adequate hydration before and after surgery, as hydration status can impact blood pressure and kidney function.

• Follow pre-surgery instructions regarding fasting or specific dietary preparations as advised by your surgical team.

• After surgery, adhere to recommended dietary guidelines to support recovery, such as high-protein meals that aid in tissue repair.

• Avoiding strenuous activities and following physical rehabilitation advice can help manage the condition necessitating Aprotinin use effectively.