Artesunate + Mefloquine is primarily used to manage acute uncomplicated malaria caused by the parasite Plasmodium falciparum and belongs to the group of antimalarial medicines.
Additionally, the combination may be utilised in areas with known mefloquine resistance and is also effective in treating severe malaria cases after initial parenteral artesunate therapy.
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Artesunate + Mefloquine is an antimalarial combination.
Artesunate, a derivative of Artemisinin, works by generating harmful reactive oxygen species within the malaria parasite. These species interfere with the synthesis of proteins that are essential for the parasite's survival.
Mefloquine, on the other hand, is a quinoline compound. It hampers the parasite's ability to digest haemoglobin, a protein in red blood cells that carries oxygen. It does this by creating toxic heme complexes.
Together, Artesunate and Mefloquine target the blood stages of the malaria-causing parasite, destroying them, and preventing the recurrence of the disease.
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Artesunate + Mefloquine is available via the oral route (tablet), intravenous or intramuscular route (injection).
This combination medicine is meant for both adults and children. However, for children, dose adjustments are necessary based on body weight.
Artesunate + Mefloquine is contraindicated in patients with known hypersensitivity to either Artesunate or Mefloquine.
It is also contraindicated in patients with a history of psychiatric disorders or seizures associated with Mefloquine use.
Lastly, it is not recommended for patients with severe hepatic impairment.
Artesunate + Mefloquine may interact with strong CYP3A4 inducers (such as rifampin and phenytoin), and strong CYP3A4 inhibitors (like ketoconazole and ritonavir), and medications that prolong the QTc interval (like quinolones, macrolides, and tricyclic antidepressants).
An overdose of Artesunate + Mefloquine may cause severe side effects like seizures or cardiotoxicity. If you suspect an overdose, seek medical help immediately.
If you miss a dose of this medicine, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose and continue with your regular schedule. Do not double your dose to compensate for the missed one.
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of fluids can help manage some gastrointestinal side effects like diarrhoea and abdominal pain.
Rest and relaxation techniques can help manage the side effects of the nervous system, such as headaches and dizziness.
Artesunate + Mefloquine may cause dizziness or fatigue in some individuals. If affected, avoid driving or operating heavy machinery.
Artesunate + Mefloquine should only be used during pregnancy if clearly needed and the benefits outweigh potential risks. It is advised that breastfeeding mothers should avoid this medication. Always consult your doctor before using this medicine during pregnancy or lactation.
Individuals with cardiac conduction abnormalities or arrhythmias should exercise caution when taking Artesunate + Mefloquine.
This medicine should also be used cautiously by individuals with electrolyte disturbances (like hypokalaemia, and hypomagnesaemia) and renal impairment.
Drink plenty of fluids to stay hydrated, which can help with the management of diarrhoea.
Avoid alcohol consumption, as it may enhance the sedative effect of this medicine.
Get adequate rest to help manage fatigue or sleep disturbances.
Frequently asked questions
No, Artesunate + Mefloquine is not an antibiotic. It is a specific combination medicine used for managing malaria caused by the Plasmodium falciparum parasite.
Yes, some people may experience common side effects such as nausea and vomiting after taking Artesunate + Mefloquine.
Yes, one of the potential side effects of Artesunate + Mefloquine is palpitations or slow heart rate (bradycardia).
Yes, Artesunate + Mefloquine can interact with other medicines, particularly those that are metabolised by the enzyme CYP3A4.
Yes, Artesunate + Mefloquine can be given to children for managing acute uncomplicated P. falciparum malaria, but the dosage would need to be adjusted according to their body weight.
Artesunate + Mefloquine is taken only as per the doctor's recommendation. Long-term daily use is not typically recommended unless advised by your doctor.
The best time to take Artesunate + Mefloquine is as per your doctor's prescription.
Artesunate + Mefloquine in other salts
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