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Artesunate + Pyrimethamine + Sulfadoxine

Uses of Artesunate + Pyrimethamine + Sulfadoxine

  • The primary use of Artesunate + Pyrimethamine + Sulfadoxine is for the management of uncomplicated malaria caused by Plasmodium falciparum. This medicine belongs to the class of antimalarial medications.

  • It has also been used in combination therapy to reduce the chances of medicine resistance developing in the malaria parasites.

Side effects of Artesunate + Pyrimethamine + Sulfadoxine

  • Nausea

  • Diarrhoea

  • Headache

  • Skin rash

  • Loss of appetite

How Artesunate + Pyrimethamine + Sulfadoxine works

  • Artesunate + Pyrimethamine + Sulfadoxine is an antimalarial combination.

  • Artesunate, an artemisinin derivative, produces harmful free radicals that damage the malaria parasites and hinder their reproduction. It is particularly effective during the blood stage of the parasite's life cycle.

  • Pyrimethamine disrupts the parasite's ability to produce folic acid, a vital component for DNA creation and multiplication, by inhibiting an enzyme known as dihydrofolate reductase (DHFR).

  • Sulfadoxine, a type of sulfonamide antibiotic, interrupts the production of the parasite's folic acid by blocking another enzyme called dihydropteroate synthetase (DHPS).

Certified content

Written By

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Dr. Michelle FrankMedical Content Writer| 8 years

Doctor of Medicine

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Artesunate + Pyrimethamine + Sulfadoxine is available as oral tablets.

Age and Dose Restrictions

  • This medicine is intended for adults and children. The dosage for children is adjusted based on their body weight. It is always best to consult your doctor for the appropriate dosage according to age and weight.

Contraindications

  • Artesunate + Pyrimethamine + Sulfadoxine is contraindicated in individuals with known allergies to any of its components.

  • It should not be used by people who have severe kidney or liver dysfunction.

Other Medications to Avoid

  • Artesunate + Pyrimethamine + Sulfadoxine may interact with other antimalarial medicines (such as mefloquine, quinine), antifolate medicines (like trimethoprim, methotrexate), anticonvulsants (like phenytoin, carbamazepine), sulfonamide antibiotics (including sulfamethoxazole), warfarin and other blood thinners, and diuretics (like furosemide).

Overdose and Missed Dose

  • An overdose of this medication can lead to serious health complications. If you suspect an overdose, seek medical assistance immediately.

  • In case you miss a dose, take it as soon as you remember. However, never double up the dose to compensate for a missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • Drinking plenty of fluids may help alleviate nausea, vomiting, diarrhoea, and headaches.

  • Taking the medication with food can help reduce stomach upset.

Use in Driving and Operating Machinery

  • This medicine may cause dizziness and fatigue, affecting your ability to drive or operate heavy machinery. If you feel dizzy or fatigued after taking this medication, avoid driving or operating machinery.

Use in Pregnancy and Lactation

  • Artesunate + Pyrimethamine + Sulfadoxine should only be used during pregnancy and breastfeeding if the potential benefit justifies the risk to the foetus. It's always best to consult your doctor.

Caution in Other Conditions

  • People with kidney or liver disease should use this medicine with caution as lower doses may be needed.

  • Regular monitoring of kidney and liver function is recommended.

  • Individuals with a history of seizures or mental illness should also exercise caution while taking this medicine.

Special Dietary and Lifestyle Recommendations

  • Maintain a balanced diet rich in fruits, vegetables, lean proteins, and whole grains to keep your immune system strong.

  • Avoid mosquito-prone areas and use protective measures such as mosquito nets and repellents to prevent malaria.

  • Regular hand hygiene practices such as washing hands with soap or using hand sanitisers can prevent infection spread.

  • Regular physical activity can help maintain overall health.

Frequently asked questions

No, Artesunate + Pyrimethamine + Sulfadoxine is not an antibiotic. It is a combination medication used specifically for the management of uncomplicated falciparum malaria.

Fatigue is a possible side effect of Artesunate + Pyrimethamine + Sulfadoxine. However, not everyone who takes this medicine will experience this side effect.

The possibility of developing resistance to Artesunate + Pyrimethamine + Sulfadoxine exists, however, the likelihood is reduced as it is a combination therapy attacking the parasite at multiple stages.

There is no direct evidence to suggest that Artesunate + Pyrimethamine + Sulfadoxine affects mood or behaviour. However, if you notice any unusual changes, you should consult your doctor immediately.

People with a history of mental health conditions should use Artesunate + Pyrimethamine + Sulfadoxine with caution and under strict medical supervision due to potential impacts on their condition.

If you have a known allergy to sulfa medicines, you should not take Artesunate + Pyrimethamine + Sulfadoxine without consulting your doctor as it contains Sulfadoxine which is a sulfonamide antibiotic.

As certain herbal supplements may interact with Artesunate + Pyrimethamine + Sulfadoxine, it is advisable to consult your doctor before starting any new medication or supplement.

Terms & Conditions


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