Aspirin + Ticagrelor
Uses of Aspirin + Ticagrelor
Aspirin + Ticagrelor is used to prevent blood clots in patients with acute coronary syndrome (ACS) or a history of myocardial infarction (MI), placing it in the group of antiplatelet medicines.
Secondary uses include reducing the risk of stent thrombosis in patients who have undergone percutaneous coronary intervention (PCI) and lowering the risk of cardiovascular events in patients with a history of MI.
Side effects of Aspirin + Ticagrelor
Bleeding (such as nosebleeds and gastrointestinal bleeding)
Shortness of breath
Headache
Dizziness
Nausea
How Aspirin + Ticagrelor works
Aspirin + Ticagrelor is a combination used to prevent blood clots and reduce the risk of cardiovascular events.
Aspirin is a COX-1 inhibitor. It works by stopping an enzyme called cyclooxygenase-1 (COX-1), which reduces the production of thromboxane A2, a molecule that triggers platelet activation and clotting. So, this means that aspirin helps to reduce the clumping of platelets and prevent clot formation in blood vessels.
Ticagrelor is a P2Y12 receptor blocker. It attaches itself to P2Y12 receptors on platelets, stopping another molecule called ADP from activating these platelets. This action of ticagrelor also helps to prevent blood clots by reducing platelet aggregation and clot formation. By working together in this way, Aspirin + Ticagrelor provides a broader and stronger defence against blood clots than either medicine would do on its own. This combination ensures that the platelets are effectively inhibited from forming clots through two different pathways, hence significantly reducing the risk of heart attacks or strokes.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Aspirin + Ticagrelor is available for oral administration in the form of tablets.
Age and Dose Restrictions
This medication is intended for use in adults of age above 18 years.
Contraindications
This combination is contraindicated in patients with a history of severe bleeding, active pathological bleeding, history of intracranial haemorrhage, severe hepatic impairment, and hypersensitivity to aspirin, ticagrelor, or any excipients.
Other Medications to Avoid
This combination may interact with anticoagulants (such as warfarin, heparin), NSAIDs (such as ibuprofen, naproxen), and other antiplatelet agents (such as clopidogrel, prasugrel).
Overdose and Missed Dose
An overdose of this medication may cause severe or major bleeding. If you observe this symptom, inform your doctor and follow their advice accordingly.
If you forget to take this medicine, take it as soon as you remember. But avoid taking a double dose to make up for the missed dose.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
For managing shortness of breath or dyspnea, ensure you are sitting in a comfortable position and try to focus on your breathing until the feeling passes.
To manage headaches or dizziness, make sure you are well hydrated and rest in a quiet and dimly lit room.
In case of nausea, aim for small frequent meals and drink plenty of water.
Use in Driving and Operating Machinery
This medication may cause dizziness. Hence, caution is advised while driving or operating heavy machinery.
Use in Pregnancy and Lactation
The use of Aspirin + Ticagrelor during pregnancy and while breastfeeding is not recommended unless directed by a doctor.
Caution in Other Conditions
Patients with mild hepatic impairment or renal conditions should exercise caution when taking this medicine.
Special Dietary and Lifestyle Recommendations
Regularly monitor your blood pressure, cholesterol levels, and blood sugar levels.
Manage stress through techniques such as relaxation exercises, meditation or yoga.
Frequently asked questions
Is Aspirin + Ticagrelor a steroid?
No, Aspirin + Ticagrelor is not a steroid. It is a combination of two antiplatelet medications used to prevent blood clots and reduce the risk of cardiovascular events.
Does Aspirin + Ticagrelor have any effect on sleep?
Aspirin + Ticagrelor is not directly associated with affecting sleep. However, side effects such as dizziness and headache might indirectly affect sleep. If you experience any persistent sleep disturbances while using this medication, consult with your doctor.
Will Aspirin + Ticagrelor affect fertility?
Aspirin + Ticagrelor is not associated with affecting fertility. However, if you have concerns about fertility, it is always best to talk to your doctor for personalized advice.
Is it safe to take Aspirin + Ticagrelor daily?
Yes, it is safe to take this medicine daily if it has been prescribed by your doctor. However, it is crucial not to discontinue abruptly without consulting your doctor due to increased risk of heart attack and stent thrombosis.
How much time does Aspirin + Ticagrelor take to work?
Aspirin + Ticagrelor begins to inhibit platelet aggregation soon after administration, but the precise onset time can vary among individuals. Always follow the dosing schedule prescribed by your doctor.
What is the best time to take Aspirin + Ticagrelor?
Aspirin + Ticagrelor can be taken with or without food. The best time to take this medicine would be as directed by your doctor, typically twice daily.
Is the Aspirin + Ticagrelor available over the counter, or do I need a prescription?
Aspirin + Ticagrelor is usually prescribed by a doctor and is not available over the counter. It should always be used under medical supervision.
Aspirin + Ticagrelor in other salts
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