Avibactam + Ceftazidime

Dosage Forms Available

• Avibactam + Ceftazidime is available in the form of a powder that is used to prepare a solution for intravenous infusion. It is administered by healthcare professionals via the intravenous route, directly into a vein.

Age and Dose Restrictions

• This medicine is meant for adults and children who are 18 years of age or older.

Contraindications

• Avibactam + Ceftazidime is contraindicated in patients with known severe allergic reactions to the components of the medicine, including avibactam, ceftazidime, other cephalosporins, or other members of the beta-lactam class.

Other Medications to Avoid

• This combination may interact with medicines that are substrates of organic anion transporter 1 (OAT1) and OAT3 kidney transporters (e.g., probenecid).

Overdose and Missed Dose

• An overdose of Avibactam + Ceftazidime may result in severe side effects such as nausea, vomiting and related complications. In case of a suspected overdose, immediate medical attention should be sought. Both ceftazidime and avibactam can be removed from the body through hemodialysis.

• In case you miss a dose of this medicine, inform your doctor immediately. Do not take an extra dose to make up for the missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any symptoms, please consult your doctor.

• If you experience nausea or vomiting after taking this medicine, try taking it with meals or snacks.

• To manage constipation, increase your intake of dietary fibre and fluids.

• If dizziness occurs, avoid sudden changes in posture.

Use in Driving and Operating Machinery

• This medicine may cause dizziness in some patients. If you feel dizzy or otherwise impaired, avoid driving or operating heavy machinery.

Use in Pregnancy and Lactation

• There are no sufficient studies on the use of Avibactam + Ceftazidime during pregnancy. Thus, it should be used only when deemed necessary by your doctor. It is unknown whether avibactam and ceftazidime pass into breast milk. Thus, breastfeeding mothers should consult their doctor before using this medicine.

Caution in Other Conditions

• Patients with impaired kidney function should exercise caution when taking Avibactam + Ceftazidime, as dose adjustments may be required based on the degree of renal impairment.

Special Dietary and Lifestyle Recommendations

• There are no special dietary and lifestyle recommendations apart from maintaining a balanced diet, staying hydrated, getting enough rest, avoiding smoking and limiting alcohol consumption.