Axitinib

Dosage Forms Available

• Axitinib is available in the form of oral tablets.

• This medicine is taken by mouth.

Age and Dose Restrictions

• Axitinib is intended for adult use only.

Contraindications

• Axitinib should not be used in patients with known hypersensitivity to the active ingredient or any of the components of the formulation.

Other Medications to Avoid

• Axitinib can interact with blood pressure lowering medicines (such as amlodipine, lisinopril), anticoagulants (such as warfarin, dabigatran), and medications affecting liver enzymes (such as ketoconazole, rifampin). It may also interact with other anti-cancer drugs (such as sunitinib, sorafenib) and medications affecting gastrointestinal pH (such as omeprazole, ranitidine).

Overdose and Missed Dose

• In case of an overdose, immediate medical attention is required as it may lead to severe adverse effects.

• If you miss a dose of Axitinib, take the next dose at your regular scheduled time. Do not double the dose to catch up.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• For the management of diarrhoea, consider adjusting the timing of medication intake.

• Stay well hydrated to help manage symptoms like dry mouth or mild dehydration from diarrhoea.

Use in Driving and Operating Machinery

• Axitinib may impair your ability to drive or operate heavy machinery. Be cautious if you feel dizzy or fatigued during treatment.

Use in Pregnancy and Lactation

• Axitinib is not recommended during pregnancy or while breastfeeding due to the potential risk to the foetus and breastfed infant.

• Consult your doctor for advice on taking Axitinib during pregnancy or lactation.

Caution in Other Conditions

• Caution is advised for patients with liver impairment when taking Axitinib. Regular liver function tests are recommended.

• Patients with a history of bleeding or thrombosis should use Axitinib with caution due to an increased risk of these events.

Special Dietary and Lifestyle Recommendations

• Maintain a balanced diet rich in fruits, vegetables, and lean proteins to support overall health.

• Monitor blood pressure regularly; consider dietary adjustments such as reducing sodium intake to manage hypertension.

• Avoid consumption of grapefruit or grapefruit juice as it can interact with Axitinib and affect its efficacy.

• Engage in light to moderate physical activities, such as walking or yoga, which can help manage fatigue and improve overall well-being.

• Manage stress through relaxation techniques like meditation or deep-breathing exercises.