Azacitidine

Dosage Forms Available

• Azacitidine is available via the subcutaneous or intravenous route (injection).

Age and Dose Restrictions

• This medicine is intended for adults aged 18 and over.

Contraindications

• It is contraindicated in patients who have known hypersensitivity to Azacitidine, mannitol and in patients with advanced malignant hepatic tumours.

Other Medications to Avoid

• Azacitidine may interact with antineoplastics (such as cyclophosphamide and methotrexate), immunosuppressants (like tacrolimus and sirolimus), and antivirals (like zidovudine and lamivudine).

Overdose and Missed Dose

• An overdose of Azacitidine may cause severe side effects such as nausea, vomiting, anaemia, and thrombocytopenia. If you experience these symptoms, inform your doctor immediately.

• If you miss a dose of this medicine, administer it as soon as you remember. However, if it is almost time for the next dose, skip the missed one. Do not administer a double dose to make up for the missed one.

Management of Side Effects

• Most side effects are temporary, generally harmless, and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• To manage nausea and vomiting, try taking your medication with food.

• If you have an injection site reaction, apply a cool compress to the area.

Use in Driving and Operating Machinery

• Azacitidine may cause fatigue and dizziness, affecting your ability to drive or operate heavy machinery. Avoid these activities if you feel tired or dizzy after administering this medication.

Use in Pregnancy and Lactation

• Azacitidine is not recommended for use during pregnancy as it may cause harm to the foetus.

• It is unknown whether Azacitidine passes into breast milk. Hence, breastfeeding mothers should avoid using this medicine unless advised by their doctor.

Caution in Other Conditions

• Patients with severe pre-existing hepatic impairment should use Azacitidine with caution as it can worsen liver problems. Close monitoring for signs of toxicity is required in these patients. It should also be used with caution in patients with renal impairment.

Special Dietary and Lifestyle Recommendations

• Individuals managing blood disorders such as MDS, JMML, or AML should maintain a balanced diet rich in fruits, vegetables, lean proteins, and whole grains to support overall health.