Baricitinib
Uses of Baricitinib
The primary use of Baricitinib is for managing conditions such as moderate to severe active rheumatoid arthritis in adults who have had an inadequate response to one or more TNF antagonist therapies. It belongs to the group of medicines known as Janus kinase (JAK) inhibitors.
Secondary uses include managing COVID-19 in certain hospitalized patients requiring supplemental oxygen, invasive mechanical ventilation, or extracorporeal membrane oxygenation (ECMO), and in adults with severe alopecia areata.
Side effects of Baricitinib
Upper respiratory tract infections
Nausea
Headache
Elevated liver enzymes
How Baricitinib works
Baricitinib is a Janus kinase (JAK) inhibitor. It works by selectively inhibiting the JAK1 and JAK2 enzymes, which are key components of the JAK-STAT signalling pathway. This pathway plays a vital role in inflammation, immune response, cell division and growth, and even tumour formation.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
This medicine is available in the form of tablets for oral administration.
Age and Dose Restrictions
Baricitinib is authorised for use in adults.
Use in children should strictly be under doctor’s supervision.
Contraindications
Baricitinib is contraindicated in patients with known hypersensitivity to Baricitinib or any of its components.
It should not be used in patients with active, serious infections including localised infections.
Uncontrolled diabetes
Severe liver impairment
Other Medications to Avoid
This medicine may interact with strong OAT3 inhibitors (such as probenecid) which could increase its exposure.
Overdose and Missed Dose
Overdosing may result in symptoms such as increased susceptibility to infection or worsening of existing infections. If an overdose occurs, consult your doctor immediately.
If you miss a dose, take it as soon as you remember. If it is close to the time for the next dose, skip the missed dose and get back to your regular dosing schedule.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening symptoms, please consult your doctor.
Drinking plenty of water can help manage minor side effects such as nausea.
Rest techniques may help manage fatigue and headaches.
Use in Driving and Operating Machinery
Baricitinib may cause dizziness. If you experience this, avoid driving or operating heavy machinery until you feel better.
Use in Pregnancy and Lactation
It should not be used during pregnancy unless the potential benefit justifies the potential risk to the foetus.
Caution in Other Conditions
Caution is advised for patients with liver disease as Baricitinib can cause liver enzyme elevations.
Patients with lymphopenia, neutropenia, or anaemia should also exercise caution.
Special Dietary and Lifestyle Recommendations
Maintaining a balanced diet can help manage the underlying condition of rheumatoid arthritis or alopecia areata.
Try to keep stress levels low as stress can trigger or worsen symptoms of these conditions.
Adequate rest and sleep are essential for overall health and well-being.
Frequently asked questions
Is Baricitinib a steroid?
No, it is not a steroid. It belongs to a class of medications called Janus kinase (JAK) inhibitors.
Does Baricitinib have any effect on sleep?
Baricitinib is not commonly associated with effects on sleep. It is a medication used to treat rheumatoid arthritis and certain other conditions and does not typically impact sleep patterns. However, individual responses can vary, and if you experience any changes in sleep while taking it, consult your doctor.
Will Baricitinib affect fertility?
Baricitinib is not commonly associated with effects on fertility. It is used to treat conditions like rheumatoid arthritis, and there is no well-established link between Baricitinib and changes in reproductive health. However, if you have concerns, it's best to discuss them with your doctor.
Is it safe to take Baricitinib daily?
Yes, it is safe to take Baricitinib daily as per your doctor's advice. However, it is crucial to follow the recommended dosage and not exceed the prescribed amount.
How much time does Baricitinib take to work?
The time taken for Baricitinib to work can vary depending on the individual and the condition being managed. You should experience some improvement in symptoms within a few weeks.
What is the best time to take Baricitinib?
This medicine can be taken at any time of the day, but it may be easiest to remember if you take it at the same time each day, with or without food.
Is Baricitinib available over the counter, or do I need a prescription?
Baricitinib usually requires a prescription from a doctor and is not generally available over the counter.
List of Medicines for Baricitinib
Company
About UsHealth ArticleHealth StoriesDiseases & Health ConditionsAll MedicinesAll BrandsNeed HelpFAQSubscribe
Registered Office Address
Grievance Officer
Download Truemeds
Contact Us
Our customer representative team is available 7 days a week from 9 am - 9 pm.
v3.7.8
2025 - Truemeds | All rights reservedOur Payment Partners
