Bempedoic Acid + Ezetimibe

Dosage Forms Available

• Bempedoic Acid + Ezetimibe is available as oral tablets.

Age and Dose Restrictions

• This medicine is meant for adult use only and is suitable for patients who are above the age of 18 years.

Contraindications

• This medicine is contraindicated in patients with moderate to severe hepatic impairment.
• It is also contraindicated for individuals with a known hypersensitivity to either Bempedoic acid or Ezetimibe.

Other Medications to Avoid

• This combination may interact with other cholesterol-lowering agents (such as simvastatin and pravastatin), immunosuppressants (including cyclosporine), and bile acid sequestrants (like cholestyramine).

Overdose and Missed Dose

• An overdose of Bempedoic Acid + Ezetimibe may lead to increased side effects such as muscle pain or weakness. If you suspect an overdose, it is important to seek immediate medical attention.
• If you miss a dose of this medicine, take it as soon as you remember. However, if it is nearly time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• To manage minor gastrointestinal discomfort, taking the medication with food may help alleviate symptoms.
• Staying well-hydrated by drinking plenty of water can help manage mild dehydration-related side effects.

Use in Driving and Operating Machinery

• This medicine typically does not impair your ability to drive or operate machinery. However, individual responses can vary, so it is advised to be cautious until you know how the medication affects you.

Use in Pregnancy and Lactation

• Bempedoic Acid + Ezetimibe is contraindicated during pregnancy. If pregnancy occurs while taking this medication, discontinue its use immediately and consult your doctor.
• It is recommended to avoid breastfeeding while taking this medication due to the potential passage into breast milk.

Caution in Other Conditions

• Caution should be taken when using Bempedoic Acid + Ezetimibe in patients with mild hepatic impairment. Regular monitoring of liver enzyme levels may be advisable.
• Patients with a history of gout should exercise caution as Bempedoic acid could potentially increase uric acid levels.

Special Dietary and Lifestyle Recommendations

• Maintain a low-cholesterol and low-fat diet to enhance the effectiveness of Bempedoic Acid + Ezetimibe in lowering LDL cholesterol.
• Regular physical activity such as walking, cycling, or swimming can help improve cardiovascular health.
• Avoid foods high in saturated fats and trans fats, such as fatty meats, full-fat dairy products, and processed snacks, which can increase cholesterol levels.
• Incorporate fibre-rich foods such as oats, legumes, fruits, and vegetables into your diet which can help absorb and eliminate cholesterol from the body.
• Smoking cessation is highly recommended as smoking can exacerbate heart disease and counteract the benefits of cholesterol-lowering medications.