Bosentan

Dosage Forms Available

• Bosentan can be taken orally (film-coated tablet and dispersible tablet).

Age and Dose Restrictions

• This medicine is primarily intended for use in adults aged 18 and older.

Contraindications

• Bosentan is contraindicated in patients with known hypersensitivity to the active substance or any of its components. It is also contraindicated in patients with severe hepatic impairment or elevated baseline liver aminotransferases.

Other Medications to Avoid

• Bosentan may interact with antifungals (ketoconazole) and antibiotics (rifampin).

Overdose and Missed Dose

• Overdose of Bosentan can have serious consequences. Seek immediate medical attention if you take more than your prescribed dose.

• If you miss a dose, take it as soon as you remember. But if it is nearly time for the next dose, skip the missed dose and return to your regular schedule.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• Increase fluid intake if you experience headache or flushing.

• Maintain hydration and rest if you experience dizziness.

Use in Driving and Operating Machinery

• Bosentan may cause side effects like dizziness or fatigue, which could potentially affect your ability to drive or operate machinery.

Use in Pregnancy and Lactation

• Bosentan is not recommended during pregnancy due to potential harm to the foetus. The use of Bosentan during lactation is not advised.

Caution in Other Conditions

• Patients with mild to moderate hepatic impairment should exercise caution when taking Bosentan.

• Renal impairment does not require dose adjustment for Bosentan, but patients with severe impairment should exercise caution.

Special Dietary and Lifestyle Recommendations

• Regular monitoring of blood pressure can help track the effectiveness of the medication.

• Too much salt can increase blood pressure, so limit your intake to less than 5 g daily. Avoid adding extra salt to your food.

• Avoid processed foods high in sodium.