Cefpodoxime + Ofloxacin

Dosage Forms Available

• Cefpodoxime + Ofloxacin can be taken orally (tablet and suspension).

Age and Dose Restrictions

• This combination can be used in adults.

Contraindications

• It is contraindicated in patients with a history of hypersensitivity to cefpodoxime or/and ofloxacin, any other cephalosporin antibiotic, quinolone, or fluoroquinolone antibiotic, patients with epilepsy, with a history of tendon disorders related to fluoroquinolone use, in children or growing adolescents, and in women who are pregnant or breastfeeding.

Medications to Avoid with This Drug

• Avoid taking antacids, H2 blockers (ranitidine), anticholinergics (propantheline), sucralfate, stomach acid reducers (cimetidine), immunosuppressants (cyclosporin), NSAIDs, oral contraceptives, antigout medications (probenecid), bronchodilators (theophylline), anticoagulants (warfarin), and antidiabetic agents (insulin, glyburide/glibenclamide). These medications may alter the safety and effectiveness of Cefpodoxime + Ofloxacin.

Overdose and Missed Dose

• Overdose can cause confusion, dizziness, impairment of consciousness, stomach disturbance, and nausea, which need to be managed as an emergency in a hospital setting. Therefore, strict adherence to the prescribed dose is essential.
• If you miss a dose of this combination, take it as soon as you remember. But, if the next dose is near, skip the missed dose and resume the regular dosing regime.

Management of Side Effects

• If side effects worsen or persist, consult your doctor for a possible treatment plan adjustment.

Use in Driving and Operating Machinery

• This combination may cause dizziness and lightheadedness. Do not drive, operate machinery, or do other activities that require mental alertness or coordination until you know how this medication affects you. 

Use in Pregnancy and Lactation

• This medicine is contraindicated during pregnancy and breastfeeding.

Caution in Other Conditions

• Caution is advised in patients with hemolytic anaemia, severe diarrhoea, epilepsy, tendonitis and those with actual defects in glucose-6-phosphate dehydrogenase (G6PD) activity, myasthenia gravis, hypoglycemia, peripheral neuropathy, and kidney and liver impairment.

Special Dietary & Lifestyle Recommendation

• Take this medicine with food to increase absorption.
• To ensure complete eradication of the infection, finish the entire prescribed course, even if symptoms improve before completion.
• Limit or avoid alcohol consumption during the course of treatment, as they can potentially interact with the medications and affect their efficacy.
• Consider incorporating probiotics into your diet or as supplements to support gastrointestinal health, as antibiotics may affect the balance of gut bacteria.
• Ofloxacin may increase sensitivity to sunlight, so use sunscreen, wear protective clothing, and avoid excessive sun exposure.