Ceftazidime
Uses of Ceftazidime
The primary use of Ceftazidime is to manage various bacterial infections, including complicated intra-abdominal infections (cIAI), complicated urinary tract infections (cUTI), respiratory tract infections, bone and joint infections, skin and soft tissue infections, bacterial meningitis, and septicaemia. Ceftazidime is a third-generation cephalosporin antibiotic.
Additionally, it is also used to prevent infections in patients undergoing certain types of surgery, such as prostate or abdominal surgeries.
Side effects of Ceftazidime
Injection site reactions
Vomiting
Itching
Blood abnormalities
Headache
How Ceftazidime works
Ceftazidime is a third-generation cephalosporin antibiotic.
It combats bacterial infections by impeding the formation of the bacterial cell wall, a crucial structure for bacterial survival and growth. Ceftazidime achieves this by binding to specific enzymes known as penicillin-binding proteins (PBPs) that play a key role in creating peptidoglycan, a significant component of the cell wall. When these proteins are inhibited, it disrupts the synthesis of the cell wall, leading to the eventual breakdown and death of the harmful bacteria.
Certified content
Written By
MSc (Applied Genetics)
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Ceftazidime is available for administration via intramuscular (injection) and intravenous (infusion) routes.
Age and Dose Restrictions
This medicine is intended for use in adults as well as children.
Contraindications
Ceftazidime is contraindicated for individuals who have a known hypersensitivity to this medicine or other cephalosporins.
It should be used with caution in patients with a history of penicillin allergy, due to potential cross-reactivity.
Other Medications to Avoid
Ceftazidime may interact with aminoglycosides (such as gentamicin and neomycin) and broad-spectrum antibiotics (such as chloramphenicol).
Overdose and Missed Dose
In cases of overdose, it's important to maintain adequate hydration and monitor renal function. Hemodialysis or peritoneal dialysis may facilitate the removal of Ceftazidime from the body.
If you miss a dose, take it as soon as you remember it. However, avoid doubling up on doses to catch up.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Try applying a cool compress to the injection site area.
Drinking plenty of fluids can also help manage some of these side effects.
Use in Driving and Operating Machinery
Ceftazidime may cause dizziness or other side effects that could affect your ability to drive or operate machinery. If you experience these symptoms, avoid these activities until you know how the medication affects you.
Use in Pregnancy and Lactation
Ceftazidime is categorised as a pregnancy category B medicine, which indicates that it should be used during pregnancy only if clearly needed and as the medicine is excreted in human milk in low concentrations, it should be used with caution in nursing mothers.
Caution in Other Conditions
Patients with renal impairment should exercise caution when taking this medicine, as dosage adjustments are necessary to prevent the accumulation of Ceftazidime in the body.
Prolonged use of Ceftazidime may lead to an overgrowth of non-susceptible organisms, including fungi.
Special Dietary and Lifestyle Recommendations
Maintain good hydration to help manage potential side effects such as gastrointestinal disturbances.
Regular hand washing and maintaining a clean environment can help prevent bacterial infections, which Ceftazidime is used to manage.
Frequently asked questions
Does administering Ceftazidime result in weight gain or loss?
No, weight gain or loss is not a common side effect of Ceftazidime. However, each person may react differently to any medication, so if you notice any significant changes in your weight, consult your doctor.
Does Ceftazidime have any effect on sleep?
Ceftazidime is not directly associated with affecting sleep. However, if you experience any changes in your sleep patterns while on this medicine, you should consult your doctor immediately.
Will Ceftazidime affect my fertility?
Ceftazidime is not directly associated with affecting fertility. However, if you are planning a pregnancy or have concerns about fertility, discuss these with your doctor.
Does Ceftazidime have an impact on mood or behaviour?
Ceftazidime does not typically have any impact on mood or behaviour. If you experience unusual mood changes or behaviours after using this medication, consult your doctor immediately.
Is it safe to administer Ceftazidime daily?
The safety of daily use of Ceftazidime depends on the nature and severity of the infection being managed. Your doctor will prescribe an appropriate dosage schedule based on your specific needs.
How much time does Ceftazidime take to work?
The time for Ceftazidime to start working can vary depending on the type and severity of the infection being managed. You should start noticing an improvement in your symptoms within a few days, but it is essential to complete the entire prescribed course for optimal results.
Is Ceftazidime available over-the-counter or do I need a prescription?
Ceftazidime is a prescription medicine and is not available over the counter.
Ceftazidime in other salts
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