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Ceftazidime + Sulbactam

Uses of Ceftazidime + Sulbactam

  • The main use of Ceftazidime + Sulbactam is in managing severe bacterial infections in hospitalized patients. It belongs to the group of cephalosporin antibiotics.

  • It is also used in the management of complicated intra-abdominal infections, urinary tract infections, hospital-acquired pneumonia, septicemia, bone and joint infections, skin and skin structure infections, meningitis, and infections in immunocompromised patients.

Side effects of Ceftazidime + Sulbactam

  • Vomiting

  • Rash

  • Diarrhoea

  • Fever

  • Headache

How Ceftazidime + Sulbactam works

  • Ceftazidime + Sulbactam combination belongs to the group of cephalosporin antibiotics.

  • Ceftazidime is a type of medicine known as a third-generation cephalosporin. It destroys bacteria by interfering with their ability to form cell walls. The cell walls are necessary for bacteria to survive, so preventing their formation, leads to the death of the bacterial cells.

  • Sulbactam is a beta-lactamase inhibitor. It works by blocking the action of enzymes produced by bacteria called beta-lactamases. These enzymes can break down some antibiotics and make them ineffective. Together, these two medicines fight against bacterial infections more effectively than either could alone.

Certified content

Written By

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Dr. Michelle FrankMedical Content Writer| 8 years

Doctor of Medicine

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Ceftazidime + Sulbactam is available as an injectable powder. It is administered through either the intramuscular or the intravenous route depending on the severity of infection and the doctor's discretion.

Age and Dose Restrictions

  • This medicine is meant for adults and children above 12 years of age.

Contraindications

  • This medicine is contraindicated in patients with known severe hypersensitivity to Ceftazidime, Sulbactam, other cephalosporins, penicillins, or beta-lactamase inhibitors.

  • It is also contraindicated in individuals with a previous history of Ceftazidime-associated cholestatic jaundice or hepatic dysfunction.

Other Medications to Avoid

  • Ceftazidime + Sulbactam may interact with uricosuric medicines (like probenecid, sulfinpyrazone), aminoglycoside antibiotics (such as gentamicin, amikacin) and Amphenicol-class Antibacterial (like chloramphenicol, thiamphenicol).

Overdose and Missed Dose

  • An overdose of Ceftazidime + Sulbactam may cause neurological reactions such as seizures. Hemodialysis can remove these substances from the body, and symptomatic treatment is recommended if an overdose occurs.

  • If you forget to administer this medicine, administer it as soon as you remember. However, if it is near the time for the next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve after discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • Drinking plenty of water can help manage side effects such as diarrhoea and vomiting. It can also help to prevent kidney damage from the medicine.

  • Resting or sitting in a comfortable position can help manage injection site reactions.

Use in Driving and Operating Machinery

  • Ceftazidime + Sulbactam does not commonly affect the ability to drive or operate machinery. However, if you experience side effects such as dizziness or confusion after administering this medication, avoid driving or operating heavy machinery.

Use in Pregnancy and Lactation

  • Ceftazidime + Sulbactam falls under pregnancy category B, meaning it can be used during pregnancy only if needed. Low concentrations are excreted in breast milk, so caution is needed when administering to nursing women.

Caution in Other Conditions

  • Patients with kidney impairment may need dosage adjustments as both Ceftazidime and Sulbactam are eliminated by the kidneys.

  • Those with a history of gastrointestinal disease, especially colitis, should also exercise caution as this medication could potentially exacerbate these conditions.

Special Dietary and Lifestyle Recommendations

  • Consuming a balanced diet rich in fruits, vegetables, lean proteins, and whole grains can support overall health and well-being, crucial for individuals battling bacterial infections.

  • Regular sleep is important to support immune function and recovery from infection.

Frequently asked questions

No, Ceftazidime + Sulbactam is not a steroid. It is an antibiotic combination used in the management of various bacterial infections.

Ceftazidime + Sulbactam is not associated with effects on sleep. These antibiotics are used to treat bacterial infections and generally do not impact sleep patterns.

Ceftazidime + Sulbactam is not associated with effects on fertility. These antibiotics are used to treat infections and do not typically impact reproductive health.

It is safe to take Ceftazidime + Sulbactam as prescribed by your doctor. The duration and frequency of the dosage should be as per doctor’s recommendation.

Ceftazidime + Sulbactam starts working soon after administration, but the exact time may vary depending on the severity and type of infection.

Yes, you do need a prescription to obtain Ceftazidime + Sulbactam as it is used to manage serious infections and should be used under medical supervision.

Yes, severe hypersensitivity reactions, including anaphylaxis, can occur with Ceftazidime + Sulbactam use. If you experience any allergic reaction, discontinue the medicine immediately and consult your doctor.

Terms & Conditions


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