Chlorambucil

Dosage Forms Available

• Chlorambucil is available for oral use in the form of tablets.

Age and Dose Restrictions

• This medication is intended for adult use only.

Contraindications

• Chlorambucil is contraindicated in patients with known hypersensitivity to it or other alkylating agents. It should also not be given to patients with severe bone marrow suppression.

Other Medications to Avoid

• Chlorambucil may interact with other chemotherapy medicines (cyclophosphamide, and methotrexate), blood thinners (like warfarin), immunosuppressants (such as cyclosporine and tacrolimus).

Overdose and Missed Dose

• Overdosing on Chlorambucil may result in severe bone marrow suppression, infections, and bleeding. Symptoms of an overdose include fever, chills, sore throat, unusual bleeding or bruising, extreme fatigue, nausea, vomiting, and diarrhoea. If these symptoms are observed, seek immediate medical attention.

• If a dose is missed, it should be taken as soon as possible unless it is almost time for the next dose. In that case, skip the missed dose and continue with your regular dosing schedule.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any symptoms, please consult your doctor.

• Drinking plenty of water can help manage mild nausea or upset stomach.

• Sucking on ice chips or taking small sips of water can help manage mouth sores.

• Rest and good sleep hygiene can help manage fatigue.

Use in Driving and Operating Machinery

• Chlorambucil may cause dizziness or blurred vision. If you experience these side effects, avoid driving or operating heavy machinery.

Use in Pregnancy and Lactation

• Chlorambucil is not recommended for use during pregnancy or while breastfeeding. Consult your doctor before taking this medicine if you are pregnant or breastfeeding.

Caution in Other Conditions

• Chlorambucil should be used with caution in patients with a history of seizures or head injury.

• Regular blood tests are necessary to monitor for low blood cell counts and liver problems.

Special Dietary and Lifestyle Recommendations

• Maintain a balanced diet to support overall health during cancer treatment.

• Get enough rest and maintain good sleep hygiene to manage fatigue.

• Avoid exposure to infections. Wash your hands regularly and avoid contact with people who are ill.

• Do not receive live vaccines during treatment with Chlorambucil.