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Chloramphenicol + Dexamethasone

Uses of Chloramphenicol + Dexamethasone

  • Chloramphenicol + Dexamethasone is a combination medication used for managing bacterial eye and ear infections. It falls under the category of antibiotic and corticosteroid medicines.

  • In addition to treating eye and ear infections, this medication is often prescribed for conditions such as bacterial conjunctivitis, blepharitis, keratitis, corneal ulcers, otitis externa, and otitis media.

Side effects of Chloramphenicol + Dexamethasone

  • Burning or stinging sensations in the eyes or ears

  • Itching or redness

  • Swelling of the eyelids

  • A sensation of a foreign body in the eye

  • Blurred vision

How Chloramphenicol + Dexamethasone works

  • Chloramphenicol works by attaching to a part of the bacteria called the 50S ribosomal subunit. This prevents the formation of peptide bonds, which are vital for protein synthesis. By blocking this process, the growth and multiplication of bacteria are stopped.

  • Dexamethasone, on the other hand, binds to glucocorticoid receptors in the body. This triggers the transcription of anti-inflammatory genes and suppresses the production of inflammation-causing agents like prostaglandins and leukotrienes. Consequently, it reduces inflammation, redness, and swelling at infected sites.

Certified content

Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Osama Ahmed
Dr. Osama Ahmed Dental/Medical Writer, Editor, Reviewer| 2 years

Bachelor of Dental Surgery

Expert Advice

Dosage Forms Available

  • Chloramphenicol + Dexamethasone is available for use via the topical route (eye drops, ear drops, and eye ointment).

Age and Dose Restrictions

  • This medication is meant for use in adults as well as children who are 2 years or older.

Contraindications

  • This medicine is contraindicated in patients with known allergies to either chloramphenicol or dexamethasone. It should also not be used in cases of viral, fungal, mycobacterial ocular infections, herpes simplex keratitis, or acute untreated bacterial infections.

Other Medications to Avoid

  • Chloramphenicol + Dexamethasone may interact with anticoagulants (such as warfarin), myelosuppressive medications (like phenylbutazone), and CYP3A4 inhibitors (like ketoconazole).

Overdose and Missed Dose

  • An overdose of this medication may lead to severe side effects such as changes in vision or hearing. If suspected, seek immediate medical attention.

  • If you forget to apply your dose, apply it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular schedule. Do not double up on doses to make up for missed ones.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • In case of minor irritation or discomfort after application, try using the medicine at a different time when you are more relaxed and comfortable.

  • If dryness occurs, using an over-the-counter lubricating eye or ear drop may help.

Use in Driving and Operating Machinery

  • This medication may cause temporary blurring of vision. As such, it's recommended to avoid driving or operating heavy machinery until your vision is clear.

Use in Pregnancy and Lactation

  • Chloramphenicol + Dexamethasone should only be used in pregnancy or while breastfeeding if recommended by your doctor, as the benefits should outweigh the potential risks.

Caution in Other Conditions

  • Patients with a history of glaucoma or cataracts should exercise caution when taking this medicine due to the dexamethasone component.

Special Dietary and Lifestyle Recommendations

  • It is advisable to maintain good hygiene practices to prevent further infection while using Chloramphenicol + Dexamethasone.

  • Regular eye and ear check-ups should be scheduled for early detection of any adverse effects associated with the prolonged use of this medication.

  • It would be beneficial to take breaks from activities requiring prolonged visual focus, such as reading or screen time, to prevent straining the eyes.

Frequently asked questions

Yes, Chloramphenicol + Dexamethasone is a combination medication that includes Dexamethasone, a potent corticosteroid, and Chloramphenicol, which is a broad-spectrum antibiotic.

Chloramphenicol + Dexamethasone is not directly associated with affecting sleep. However, if you experience any sleep disturbances while using this medicine, consult your doctor.

Chloramphenicol + Dexamethasone is not directly associated with affecting fertility. However, any concerns regarding fertility and medication use should be discussed with your doctor.

Chloramphenicol + Dexamethasone should be used exactly as directed by your doctor. This may involve daily use, but it is critical not to exceed the recommended dosage.

Typically, improvements are observed within 2-3 days of starting therapy with Chloramphenicol + Dexamethasone. However, complete resolution of symptoms may take up to 7-10 days.

The best time to take or apply Chloramphenicol + Dexamethasone should be advised by your doctor, based on the specific condition being managed.

Yes, as it is a potent combination of an antibiotic and a corticosteroid, Chloramphenicol + Dexamethasone usually requires a doctor's prescription.

Terms & Conditions


Available medicines for CHLORAMPHENICOL + DEXAMETHASONE
Decol C Eye Drops 5 ML
Decol C Eye Drops 5 ML
Intas Pharmaceuticals Ltd
Pack of 5 ML
₹7.36
MRP ₹8.98
18.00% OFF
Biodexone C 0.05 % Drops 10 ML
Biodexone C 0.05 % Drops 10 ML
Zydus Healthcare Ltd
Pack of 10 ML
₹8.09
MRP ₹9.86
18.00% OFF
Pyrimon 1/0.1 % Eye Drops 5 ML
Pyrimon 1/0.1 % Eye Drops 5 ML
Fdc Ltd.
Pack of 5 ML
₹11.28
MRP ₹13.75
18.00% OFF
Chlormet Dm Eye Drops 5 ML
Chlormet Dm Eye Drops 5 ML
Sun Pharma Laboratories Ltd.
Pack of 5 ML
₹9.63
MRP ₹11.75
18.00% OFF
Opthodex 1/0.1 % Eye Drops 5 ML
Opthodex 1/0.1 % Eye Drops 5 ML
Optho Remedies Pvt.ltd
Pack of 5 ML
₹7.71
MRP ₹9.40
18.00% OFF
Chlorocol D Eye Drops 10 ML
Chlorocol D Eye Drops 10 ML
Jawa Laboratories
Pack of 10 ML
₹7.99
MRP ₹9.74
18.00% OFF
Polydex 1/0.1  % Eye/ear Drops 5 ML
Polydex 1/0.1 % Eye/ear Drops 5 ML
Kaizen Pharma
Pack of 5 ML
₹39.36
MRP ₹48.00
18.00% OFF
Odomycetin D Eye/ear Drops 10 ML
Odomycetin D Eye/ear Drops 10 ML
Odento Pharma
Pack of 10 ML
₹80.36
MRP ₹98.00
18.00% OFF

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