Chlorpheniramine Maleate + Paracetamol + Phenylephrine
COLD PREPARATIONUses of Chlorpheniramine Maleate + Paracetamol + Phenylephrine
- Paracetamol+Phenylephrine Hydrochloride+Chlorpheniramine Maleate is used to ease symptoms linked with colds and flu, including fever, nasal congestion, headaches, and minor aches and pains.
Side effects of Chlorpheniramine Maleate + Paracetamol + Phenylephrine
- Drowsiness
- Nervousness
- Headache
- Dizziness
- Blurred vision
- Constipation
- Dry mouth
- Insomnia
How Chlorpheniramine Maleate + Paracetamol + Phenylephrine works
- Paracetamol primarily acts in the central nervous system (CNS), where it raises the pain threshold by inhibiting both COX-1, COX-2, and COX-3 enzymes involved in prostaglandin (PG) synthesis. Additionally, its antipyretic (fever-reducing) properties are likely attributed to direct effects on the heat-regulating centres of the hypothalamus. This leads to peripheral vasodilation, increased sweating, and subsequently, dissipation of heat.
- Phenylephrine reduces nasal congestion by targeting α1-adrenergic receptors in the arterioles of the nasal mucosa, causing constriction. This action reduces swelling and promotes improved drainage from the sinus cavities.
- During allergic reactions, allergens activate surface IgE antibodies on mast cells and basophils, leading to cell degranulation and the release of histamine and other mediators. Histamine affects tissues through histamine receptors, causing itching, vasodilation, low blood pressure, flushing, headaches, rapid heart rate, bronchoconstriction, increased vascular permeability, and enhanced pain. Chlorpheniramine maleate binds to H1 receptors, blocking histamine's effects and providing temporary relief from symptoms.
Certified content
Written By
Amit SharmaClinical Health & Medical Writer| 3 years
B. Pharm
Reviewed By
Amatul Ameen Clinical Health & Medical Writer| 12 years
B. Pharm, MSc.
Expert Advice
Dosage Forms Available
- Paracetamol+Phenylephrine Hydrochloride+Chlorpheniramine is available for use via oral route (syrup) and tablets.
Age and Dose Restrictions
- This medicine is meant for adults and children above 6 years of age.
Contraindications
- This medicine is contraindicated in patients with known allergies to paracetamol or phenylephrine hydrochloride, chlorpheniramine and patients with severe hypertension.
Other Medications To Avoid With This Medicine
- Significant drug interactions can happen when Paracetamol+Phenylephrine Hydrochloride+Chlorpheniramine is taken with monoamine oxidase inhibitors, tricyclic antidepressants, beta-adrenergic agents, methyldopa, reserpine, and veratrum alkaloids.
Overdose and Missed Dose
- An overdose of this medication may cause increased stimulation, difficulty with coordination (ataxia), heightened excitement, hallucinations, muscle tremors, seizures (convulsions), dilated pupils, dry mouth, flushed face, and high fever (hyperpyrexia). If you observe this symptom, inform your doctor and follow the advice accordingly.
- If you forget to take this medicine, take it as soon as you remember. If it is already time for the next dose, skip the previous one and continue with the next one. But avoid repeating the dose.
Management Of Side Effects
- Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Use In Driving And Operating Machinery
- This medication may impair your ability to drive or operate machinery.
Use in Pregnancy and Lactation
- This medicine is not recommended in pregnancy and breastfeeding.
Caution In Other Conditions
- Patients with renal or hepatic conditions should exercise caution when taking this medicine.
Special Dietary & Lifestyle Recommendation
- Wash your hands regularly with soap and water to stop germs from spreading.
- Boost your overall health by consuming plenty of foods rich in beneficial bacteria, such as yoghurt.
- Stay hydrated by drinking lots of fluids to prevent dehydration.
- Soothe a sore throat by gargling with salt water.
- Refrain from drinking alcohol while taking this medication, as it may lead to tiredness, drowsiness, or difficulty concentrating.
Frequently asked questions
How much time doesParacetamol+Phenylephrine Hydrochloride+Chlorpheniramine take to work?
This medicine's onset of action may require a few hours for full efficacy to be realised.
What warnings and precautions should I take while taking Paracetamol+Phenylephrine Hydrochloride+Chlorpheniramine?
If you're allergic to this medicine, don't take it. Seek medical help right away if you have any allergic reactions. Also, exercise caution while taking this combination if you have liver problems or severe hypertension.
Can I stop taking Paracetamol+Phenylephrine Hydrochloride+Chlorpheniramine if I feel healthy?
Please do not discontinue Paracetamol+Phenylephrine Hydrochloride+Chlorpheniramine without consulting your doctor first. Abruptly stopping the medication may result in the return of symptoms.
Is it safe for patients with kidney or liver issues?
Patients with renal or hepatic conditions should exercise caution when taking this medicine.
Will Paracetamol+Phenylephrine Hydrochloride+Chlorpheniramine affect fertility?
This medication does not affect your fertility, however, discuss it with your doctor before taking it
Chlorpheniramine Maleate + Paracetamol + Phenylephrine in other salts
ACECLOFENAC + PARACETAMOL/ACETAMINOPHENACECLOFENAC + PARACETAMOL/ACETAMINOPHEN + SERRATIOPEPTIDASEDICLOFENAC + PARACETAMOL/ACETAMINOPHENPARACETAMOL/ACETAMINOPHENIBUPROFEN + PARACETAMOL/ACETAMINOPHENNIMESULIDE + PARACETAMOL/ACETAMINOPHENCHLORZOXAZONE + DICLOFENAC + PARACETAMOLDICLOFENAC + PARACETAMOL + SERRATIOPEPTIDASEACECLOFENAC + PARACETAMOL + CHLORZOXAZONEMEFENAMIC ACID + PARACETAMOLCHLORPHENIRAMINE MALEATECETIRIZINE + PARACETAMOL + PHENYLEPHRINECHLORPHENIRAMINE MALEATE + DEXTROMETHORPHAN HYDROBROMIDECHLORPHENIRAMINE MALEATE + PHENYLEPHRINEDICYCLOMINE + PARACETAMOLPARACETAMOL + CAFFEINECHLORPHENIRAMINE MALEATE + PHENYLEPHRINE HYDROCHLORIDEACECLOFENAC + PARACETAMOL/ACETAMINOPHEN + RABEPRAZOLECHLORPHENIRAMINE + DEXTROMETHORPHAN + PHENYLEPHRINEDEXTROPROPOXYPHENE + PARACETAMOL/ACETAMINOPHENLORNOXICAM + PARACETAMOL/ACETAMINOPHENNIMESULIDE + PARACETAMOL/ACETAMINOPHEN + SERRATIOPEPTIDASECHLORPHENIRAMINE MALEATE + DEXTROMETHORPHAN HYDROBROMIDE + PHENYLEPHRINECHLORPHENIRAMINE MALEATE + DEXTROMETHORPHAN HYDROBROMIDE + PHENYLEPHRINE HYDROCHLORIDECAFFEINE + LEVOCETIRIZINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECETIRIZINE + PARACETAMOL/ACETAMINOPHEN + PSEUDOEPHEDRINECPM + PARACETAMOL/ACETAMINOPHEN + PHENYLPROPANOLAMINECHLORPHENIRAMINE MALEATE + DEXTROMETHORPHAN + PHENYLEPHRINEAMMONIUM CHLORIDE + CHLORPHENIRAMINE MALEATE + SODIUM CITRATEPHENYLEPHRINE + TROPICAMIDECHLORPHENIRAMINE MALEATE + DEXTROMETHORPHANCHLORPHENIRAMINE MALEATE + MENTHOL + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINE + SODIUM CITRATECHLORPHENIRAMINE MALEATE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINE + SODIUM CITRATEMETOCLOPRAMIDE + PARACETAMOL/ACETAMINOPHENCETIRIZINE + DEXTROMETHORPHAN + PHENYLEPHRINELEVOCETIRIZINE + PHENYLEPHRINECAFFEINE + CHLORPHENIRAMINE MALEATE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINEAMBROXOL + CHLORPHENIRAMINE MALEATE + GUAIFENESIN + MENTHOL + PHENYLEPHRINEACECLOFENAC + PARACETAMOL/ACETAMINOPHEN + THIOCOLCHICOSIDEACECLOFENAC + PARACETAMOL/ACETAMINOPHEN + TRAMADOLCAFFEINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECAFFEINE + DIPHENHYDRAMINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINEDICLOFENAC + PARACETAMOL/ACETAMINOPHEN + TRYPSIN-CHYMOTRYPSINBROMHEXINE + CHLORPHENIRAMINE MALEATE + GUAIFENESIN + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECHLORZOXAZONE + NIMESULIDE + PARACETAMOL/ACETAMINOPHENPARACETAMOL/ACETAMINOPHEN + THIOCOLCHICOSIDE
Available medicines for CHLORPHENIRAMINE MALEATE + PARACETAMOL + PHENYLEPHRINE
Sorry we currently were not able to find medicines related to CHLORPHENIRAMINE MALEATE + PARACETAMOL + PHENYLEPHRINE.
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