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Chlorpromazine

Uses of Chlorpromazine

  • The primary use of Chlorpromazine is in the management of psychiatric disorders such as schizophrenia and bipolar disorder. It falls under the class of antipsychotic medicines.

  • Other uses include control of severe behavioural problems in children when other treatments have failed, prevention of nausea and vomiting due to various causes, including surgery, management of restlessness and anxiety before surgical procedures, relief from intractable hiccups, and as an adjunct in managing tetanus symptoms.

Side effects of Chlorpromazine

  • Dizziness or light-headedness

  • Dry mouth

  • Blurred vision

  • Constipation

  • Weight gain

  • Erectile dysfunction

  • Irregular menstrual period

How Chlorpromazine works

  • Chlorpromazine is an antipsychotic medicine, belonging to the phenothiazine class.

  • Its primary mode of operation involves blocking dopamine receptors in the brain. Dopamine is a neurotransmitter, essentially a chemical messenger, that influences various brain functions. When there is an imbalance in dopamine levels, it can lead to symptoms of psychiatric disorders. By blocking these receptors, Chlorpromazine prevents dopamine from acting excessively, thus helping restore the necessary chemical balance.

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Written By

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Dr. Michelle FrankMedical Content Writer| 8 years

Doctor of Medicine

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage forms available

  • Chlorpromazine can be taken orally (tablets and syrup) and administered intramuscularly and intravenous route (injection).

Age and dose restrictions

  • Chlorpromazine can be given to both adults, and children aged 6 months and above.

Contraindications

  • Chlorpromazine is contraindicated in patients who have known hypersensitivity to it or other phenothiazines. It should not be administered to patients who are in a comatose state or have significant central nervous system depression. Patients with severe liver disease or cardiovascular disease should avoid using Chlorpromazine. This medicine should not be administered to patients with bone marrow suppression or blood dyscrasias.

Other medications to avoid

  • Chlorpromazine can interact with other medications such as CNS depressants (like diazepam and alprazolam), opioids (such as morphine), antihypertensives (like metoprolol), diuretics (such as furosemide), anticholinergics (like atropine) and anti-arrhythmia medications (such as procainamide and Quinidine).

Overdose and missed dose

  • Overdosing on Chlorpromazine could lead to symptoms like drowsiness, extrapyramidal symptoms, and cardiac arrhythmias. If you suspect an overdose, it is crucial to contact your doctor immediately.

  • If you miss a dose of Chlorpromazine, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up the doses.

Management of side effects

Most side effects of Chlorpromazine are temporary and resolve once the medicine is discontinued. However, if you experience severe side effects or worsening of symptoms, consult your doctor immediately.

  • If Chlorpromazine makes you drowsy or dizzy, try taking it before bedtime to reduce daytime drowsiness.

  • Drinking plenty of water can help manage dry mouth caused by this medicine.

Use in driving and operating machinery

  • Chlorpromazine may cause dizziness or drowsiness that could impair your ability to drive or operate heavy machinery. It is advised to avoid such activities until you know how this medicine affects you.

Use in pregnancy and lactation

  • Chlorpromazine should only be used during pregnancy or while breastfeeding if the benefits justify the potential risks. Always consult your doctor before initiating therapy with this medication during these periods.

Caution in other conditions

  • Caution should be exercised when administering Chlorpromazine to patients with renal or hepatic impairment, as they may require lower doses. Elderly patients or those with a history of cardiovascular, cerebrovascular, or respiratory disorders should also exercise caution while using this medication.

Special dietary and lifestyle recommendations

  • Adequate hydration is important, particularly for patients experiencing dry mouth as a side effect of Chlorpromazine.

  • Good sleep hygiene practices can help manage sleep disturbances associated with psychiatric disorders.

Frequently asked questions

No, Chlorpromazine is not a steroid. It is an antipsychotic medication used to manage various psychiatric conditions.

Chlorpromazine can cause drowsiness and sedation, which might improve sleep. However, you should always follow your doctor's instructions regarding its use.

Chlorpromazine is not directly associated with affecting fertility. However, if you have concerns about this, it is best to consult your doctor.

Yes, it can be safe to take Chlorpromazine daily if your doctor has prescribed it for managing your condition. Always follow the prescribed dosage and schedule.

Chlorpromazine can take several weeks to show its full effect in managing psychiatric symptoms. However, its sedative and antiemetic effects can be seen sooner.

The best time to take Chlorpromazine depends on the specific instructions provided by your doctor and the condition being managed.

The duration of treatment with Chlorpromazine is determined by your doctor based on your condition, its severity, and your response to the medicine.

Terms & Conditions


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