Chlorpromazine + Trifluoperazine + Trihexyphenidyl

Dosage Forms Available

• Chlorpromazine + Trifluoperazine + Trihexyphenidyl is available in the form of tablets and is taken orally.

Age and Dose Restrictions

• This medicine is meant for use by adults.

Contraindications

• This combination is contraindicated in patients with known hypersensitivity to any of its components.

• It is also contraindicated in those with a history of agranulocytosis, narrow-angle glaucoma, and severe central nervous system depression.

Other Medications to Avoid

• Chlorpromazine + Trifluoperazine + Trihexyphenidyl may interact with CNS depressants (such as benzodiazepines), antihypertensives (like atenolol), other anticholinergics (such as atropine), epileptogenic medications (including bupropion), and QT-prolonging medications (like amiodarone).

Overdose and Missed Dose

• Symptoms of overdose include deep CNS depression, hypotension, tachycardia, QT prolongation, seizures, and anticholinergic toxicity. Immediate medical attention is required.

• If you miss a dose of this medicine, take it as soon as you remember unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• If you experience dry mouth, sip water regularly or suck on sugar-free hard candy.

• For constipation, try increasing dietary fibre intake by eating more fruits, vegetables, and whole grains.

Use in Driving and Operating Machinery

• This medicine may impair your ability to drive or operate machinery. Avoid such activities if you experience dizziness or sedation after taking this medication.

Use in Pregnancy and Lactation

• Chlorpromazine + Trifluoperazine + Trihexyphenidyl may cause withdrawal symptoms in neonates when used during the third trimester. It is generally not recommended during pregnancy and lactation.

• Always consult your doctor before using this medication if you are pregnant or breastfeeding.

Caution in Other Conditions

• Patients with cardiovascular disease, seizure disorders, prostate enlargement (BPH), and hepatic or renal impairment should exercise caution when using this medication.

• Due to increased risks, it should be used cautiously in elderly patients with dementia.

Special Dietary and Lifestyle Recommendations

• Maintain a balanced diet rich in fruits, vegetables, and whole grains to help manage constipation.

• Stay hydrated by drinking plenty of water throughout the day to help counteract dry mouth and aid digestion.

• Engage in regular physical activity as advised by your doctor to improve overall health and manage stress.

• Ensure adequate rest and sleep to help manage stress and fatigue associated with psychiatric conditions.

• Avoid caffeine and alcohol as they can exacerbate certain side effects like insomnia and nervousness.