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Chlorpromazine + Trifluoperazine + Trihexyphenidyl

Uses of Chlorpromazine + Trifluoperazine + Trihexyphenidyl

The primary use of Chlorpromazine + Trifluoperazine + Trihexyphenidyl is to manage certain psychiatric disorders, primarily schizophrenia. It is part of the antipsychotic and anticholinergic classes of medicines.

Side effects of Chlorpromazine + Trifluoperazine + Trihexyphenidyl

  • Sedation

  • Dizziness

  • Dry mouth

  • Constipation

  • Weight gain

How Chlorpromazine + Trifluoperazine + Trihexyphenidyl works

  • Chlorpromazine + Trifluoperazine + Trihexyphenidyl is a combination of two antipsychotics and an anticholinergic.

  • Chlorpromazine and Trifluoperazine are both from the phenothiazine class of antipsychotic medications. Their primary action is to block dopamine D2 receptors in the brain. Excessive activity of dopamine is believed to trigger symptoms of schizophrenia. By subduing the effects of dopamine, these medicines help reduce hallucinations, delusions, and disorganised thoughts.

  • Trihexyphenidyl is an anticholinergic medication used to manage the side effects of antipsychotics. It operates by opposing acetylcholine at muscarinic receptors in the central and peripheral nervous system. This helps decrease involuntary movements and muscle stiffness, often seen as side effects of the antipsychotic components.

Certified content

Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Chlorpromazine + Trifluoperazine + Trihexyphenidyl is available in the form of tablets and is taken orally.

Age and Dose Restrictions

  • This medicine is meant for use by adults.

Contraindications

  • This combination is contraindicated in patients with known hypersensitivity to any of its components.

  • It is also contraindicated in those with a history of agranulocytosis, narrow-angle glaucoma, and severe central nervous system depression.

Other Medications to Avoid

  • Chlorpromazine + Trifluoperazine + Trihexyphenidyl may interact with CNS depressants (such as benzodiazepines), antihypertensives (like atenolol), other anticholinergics (such as atropine), epileptogenic medications (including bupropion), and QT-prolonging medications (like amiodarone).

Overdose and Missed Dose

  • Symptoms of overdose include deep CNS depression, hypotension, tachycardia, QT prolongation, seizures, and anticholinergic toxicity. Immediate medical attention is required.

  • If you miss a dose of this medicine, take it as soon as you remember unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • If you experience dry mouth, sip water regularly or suck on sugar-free hard candy.

  • For constipation, try increasing dietary fibre intake by eating more fruits, vegetables, and whole grains.

Use in Driving and Operating Machinery

  • This medicine may impair your ability to drive or operate machinery. Avoid such activities if you experience dizziness or sedation after taking this medication.

Use in Pregnancy and Lactation

  • Chlorpromazine + Trifluoperazine + Trihexyphenidyl may cause withdrawal symptoms in neonates when used during the third trimester. It is generally not recommended during pregnancy and lactation.

  • Always consult your doctor before using this medication if you are pregnant or breastfeeding.

Caution in Other Conditions

  • Patients with cardiovascular disease, seizure disorders, prostate enlargement (BPH), and hepatic or renal impairment should exercise caution when using this medication.

  • Due to increased risks, it should be used cautiously in elderly patients with dementia.

Special Dietary and Lifestyle Recommendations

  • Maintain a balanced diet rich in fruits, vegetables, and whole grains to help manage constipation.

  • Stay hydrated by drinking plenty of water throughout the day to help counteract dry mouth and aid digestion.

  • Engage in regular physical activity as advised by your doctor to improve overall health and manage stress.

  • Ensure adequate rest and sleep to help manage stress and fatigue associated with psychiatric conditions.

  • Avoid caffeine and alcohol as they can exacerbate certain side effects like insomnia and nervousness.

Frequently asked questions

Yes, one of the common side effects of Chlorpromazine + Trifluoperazine + Trihexyphenidyl is weight gain.

This combination is designed to manage schizophrenia and related disorders, which may help to stabilise mood in individuals with these conditions.

No. However, it is always advised to use this medicine as per your doctor's instructions to avoid any potential complications.

Please consult with your doctor for vegetarian alternatives to this medicine.

There is no specific information suggesting this combination affects menstruation. However, if you notice any changes during your menstrual cycle while taking this medicine, please consult your doctor.

It is generally not recommended as alcohol may interact with this combination and can cause adverse effects.

If you experience allergy symptoms such as rashes, shortness of breath, or swelling of the face or throat, stop taking the medicine immediately and seek medical attention.

Terms & Conditions


Available medicines for CHLORPROMAZINE + TRIFLUOPERAZINE + TRIHEXYPHENIDYL
Chlorfluhex 50/2/5 MG Tablet 10
Chlorfluhex 50/2/5 MG Tablet 10
A.n.pharmacia
Pack of 10 Units
₹24.35
MRP ₹29.70
18.00% OFF
Egret Plus 50/2/5 MG Tablet 10
Egret Plus 50/2/5 MG Tablet 10
Thrift Pharmaceuticals
Pack of 10 Units
₹21.32
MRP ₹26.00
18.00% OFF
Manocalm Forte 50/2/5 MG Tablet 10
Manocalm Forte 50/2/5 MG Tablet 10
Orchid Chemicals & Pharmaceuticals Ltd
Pack of 10 Units
₹3.81
MRP ₹4.65
18.00% OFF
Neocalm Forte 50/5/2 MG Tablet 10
Neocalm Forte 50/5/2 MG Tablet 10
Intas Pharmaceuticals Ltd
Pack of 10 Units
₹6.15
MRP ₹7.50
18.00% OFF
Maricalm Forte 50/2/5 MG Tablet 10
Maricalm Forte 50/2/5 MG Tablet 10
Mayflower India
Pack of 10 Units
₹5.54
MRP ₹6.75
18.00% OFF
Reset Forte Tablet 10
Reset Forte Tablet 10
Aarpik Remedies Pvt.ltd.
Pack of 10 Units
₹14.76
MRP ₹18.00
18.00% OFF
Lacalm Forte 50/2/5 MG Tablet 10
Lacalm Forte 50/2/5 MG Tablet 10
La Pharmaceuticals
Pack of 10 Units
₹18.29
MRP ₹22.30
18.00% OFF
Kivicalm Forte Tablet 10
Kivicalm Forte Tablet 10
Kivi Labs Ltd
Pack of 10 Units
₹13.53
MRP ₹16.50
18.00% OFF

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