The primary use of Chlorpromazine + Trifluoperazine + Trihexyphenidyl is to manage certain psychiatric disorders, primarily schizophrenia. It is part of the antipsychotic and anticholinergic classes of medicines.
Sedation
Dizziness
Dry mouth
Constipation
Weight gain
Chlorpromazine + Trifluoperazine + Trihexyphenidyl is a combination of two antipsychotics and an anticholinergic.
Chlorpromazine and Trifluoperazine are both from the phenothiazine class of antipsychotic medications. Their primary action is to block dopamine D2 receptors in the brain. Excessive activity of dopamine is believed to trigger symptoms of schizophrenia. By subduing the effects of dopamine, these medicines help reduce hallucinations, delusions, and disorganised thoughts.
Trihexyphenidyl is an anticholinergic medication used to manage the side effects of antipsychotics. It operates by opposing acetylcholine at muscarinic receptors in the central and peripheral nervous system. This helps decrease involuntary movements and muscle stiffness, often seen as side effects of the antipsychotic components.
BDS, MDS
BMS, FMC, MD Resident
Chlorpromazine + Trifluoperazine + Trihexyphenidyl is available in the form of tablets and is taken orally.
This medicine is meant for use by adults.
This combination is contraindicated in patients with known hypersensitivity to any of its components.
It is also contraindicated in those with a history of agranulocytosis, narrow-angle glaucoma, and severe central nervous system depression.
Chlorpromazine + Trifluoperazine + Trihexyphenidyl may interact with CNS depressants (such as benzodiazepines), antihypertensives (like atenolol), other anticholinergics (such as atropine), epileptogenic medications (including bupropion), and QT-prolonging medications (like amiodarone).
Symptoms of overdose include deep CNS depression, hypotension, tachycardia, QT prolongation, seizures, and anticholinergic toxicity. Immediate medical attention is required.
If you miss a dose of this medicine, take it as soon as you remember unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
If you experience dry mouth, sip water regularly or suck on sugar-free hard candy.
For constipation, try increasing dietary fibre intake by eating more fruits, vegetables, and whole grains.
This medicine may impair your ability to drive or operate machinery. Avoid such activities if you experience dizziness or sedation after taking this medication.
Chlorpromazine + Trifluoperazine + Trihexyphenidyl may cause withdrawal symptoms in neonates when used during the third trimester. It is generally not recommended during pregnancy and lactation.
Always consult your doctor before using this medication if you are pregnant or breastfeeding.
Patients with cardiovascular disease, seizure disorders, prostate enlargement (BPH), and hepatic or renal impairment should exercise caution when using this medication.
Due to increased risks, it should be used cautiously in elderly patients with dementia.
Maintain a balanced diet rich in fruits, vegetables, and whole grains to help manage constipation.
Stay hydrated by drinking plenty of water throughout the day to help counteract dry mouth and aid digestion.
Engage in regular physical activity as advised by your doctor to improve overall health and manage stress.
Ensure adequate rest and sleep to help manage stress and fatigue associated with psychiatric conditions.
Avoid caffeine and alcohol as they can exacerbate certain side effects like insomnia and nervousness.
Frequently asked questions
Yes, one of the common side effects of Chlorpromazine + Trifluoperazine + Trihexyphenidyl is weight gain.
This combination is designed to manage schizophrenia and related disorders, which may help to stabilise mood in individuals with these conditions.
No. However, it is always advised to use this medicine as per your doctor's instructions to avoid any potential complications.
Please consult with your doctor for vegetarian alternatives to this medicine.
There is no specific information suggesting this combination affects menstruation. However, if you notice any changes during your menstrual cycle while taking this medicine, please consult your doctor.
It is generally not recommended as alcohol may interact with this combination and can cause adverse effects.
If you experience allergy symptoms such as rashes, shortness of breath, or swelling of the face or throat, stop taking the medicine immediately and seek medical attention.
Chlorpromazine + Trifluoperazine + Trihexyphenidyl in other salts
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