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Chlorpromazine + Trihexyphenidyl

Uses of Chlorpromazine + Trihexyphenidyl

  • Chlorpromazine + Trihexyphenidyl is principally used for the management of schizophrenia, a severe mental disorder. It belongs to the class of antipsychotic and anticholinergic medicines.

  • It is also used to control extrapyramidal side effects that are induced by antipsychotic medications, such as muscle spasms, tremors, and restlessness.

Side effects of Chlorpromazine + Trihexyphenidyl

  • Sedation or drowsiness

  • Dizziness or a headache

  • Dry mouth or blurred vision

  • Weight gain

  • Orthostatic hypotension

How Chlorpromazine + Trihexyphenidyl works

  • Chlorpromazine + Trihexyphenidyl is a combination of an antipsychotic and an anticholinergic.

  • Chlorpromazine is classified as an antipsychotic medication. It largely functions by hindering the dopamine D2 receptors in your brain. An excess of dopamine activity is believed to cause the symptoms of schizophrenia. By reducing this activity, chlorpromazine aids in managing psychotic symptoms.

  • Trihexyphenidyl is an anticholinergic medication. It inhibits the action of acetylcholine, thereby balancing the activity of dopamine-acetylcholine to control movement-related side effects without diminishing the antipsychotic effectiveness of chlorpromazine.

Certified content

Written By

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Dr. Michelle FrankMedical Content Writer| 8 years

Doctor of Medicine

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Chlorpromazine + Trihexyphenidyl can be taken orally in the form of tablets and liquids.

Age and Dose Restrictions

  • Chlorpromazine + Trihexyphenidyl is typically prescribed for adults above the age of 18 years.

Contraindications

  • This medicine is contraindicated in patients with a known hypersensitivity to either chlorpromazine or trihexyphenidyl or any of the components of the formulation.

  • It is also contraindicated in patients with conditions such as comatose states, severe central nervous system depression, certain blood dyscrasias, narrow-angle glaucoma, severe liver or kidney impairment and bone marrow suppression.

Other Medications to Avoid

  • Chlorpromazine + Trihexyphenidyl may interact with central nervous system depressants (such as phenobarbital), anticholinergics (like atropine and scopolamine), tricyclic antidepressants (such as amitriptyline and imipramine) and antihypertensives (like lisinopril and amlodipine).

Overdose and Missed Dose

  • Overdosing on Chlorpromazine + Trihexyphenidyl may cause serious adverse effects, such as neuroleptic malignant syndrome or tardive dyskinesia. Immediate medical attention is required in case of an overdose.

  • If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • If the medication causes dry mouth, drink plenty of water or chew sugarless gum to stimulate saliva production.

  • If you experience drowsiness or dizziness, ensure that you are well-rested before performing activities that require alertness.

Use in Driving and Operating Machinery

  • Chlorpromazine + Trihexyphenidyl may cause drowsiness and impair your ability to drive or operate heavy machinery. Avoid these activities if you feel dizzy or sleepy after taking this medication.

Use in Pregnancy and Lactation

  • The use of Chlorpromazine + Trihexyphenidyl during pregnancy or while breastfeeding is generally not recommended unless your doctor deems it necessary.

Caution in Other Conditions

  • Caution is advised when using Chlorpromazine + Trihexyphenidyl in patients with liver or kidney disease.

  • Elderly patients and those with brain damage should also use this medicine with caution as they may be more susceptible to its side effects.

Special Dietary and Lifestyle Recommendations

  • A healthy diet rich in fruits, vegetables, whole grains and lean proteins can help improve overall mental health.

  • Regular physical activity can also improve mental well-being and may enhance the effectiveness of mental health treatments.

  • Adequate sleep is essential for mental well-being. Try to establish a regular sleep schedule and maintain good sleep hygiene.

Frequently asked questions

No, Chlorpromazine + Trihexyphenidyl is not a steroid. Chlorpromazine is an antipsychotic, and Trihexyphenidyl is an anticholinergic used to manage side effects of antipsychotic medications.

Yes, one of the common side effects of Chlorpromazine + Trihexyphenidyl is sedation or drowsiness, which might affect sleep patterns. It is advisable to take it under the supervision of a doctor.

Chlorpromazine + Trihexyphenidyl is not directly associated with affecting fertility. It is advisable to consult your doctor if you have concerns related to fertility while taking this medicine.

Yes, this medicine can be taken daily as prescribed by a doctor. Remember to follow all instructions related to dosage and timing.

The exact time for this medicine to start working can vary for different individuals. Consult your doctor for more details.

Chlorpromazine + Trihexyphenidyl is a prescription medicine, and it cannot be bought over the counter.

Yes, Chlorpromazine + Trihexyphenidyl can have an impact on your mood as it helps in managing the symptoms of schizophrenia, including hallucinations and delusions, which can affect your feelings and emotions.

Terms & Conditions


Available medicines for CHLORPROMAZINE + TRIHEXYPHENIDYL
Talentil Plus 100/2 MG Tablet 10
Talentil Plus 100/2 MG Tablet 10
Talent India
Pack of 10 Units
₹14.47
MRP ₹17.65
18.00% OFF
Relitil Plus 100/2 MG Tablet 10
Relitil Plus 100/2 MG Tablet 10
Reliance Formulation Pvt Ltd
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₹14.76
MRP ₹18.00
18.00% OFF
Emetil Plus 100/2 MG Tablet 10
Emetil Plus 100/2 MG Tablet 10
La Pharmaceuticals
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₹16.88
MRP ₹20.59
18.00% OFF
Promexy 100/2 MG Tablet 10
Promexy 100/2 MG Tablet 10
Gujarat Terce Laboratories Ltd
Pack of 10 Units
₹17.65
MRP ₹21.52
18.00% OFF
Promexy Hf 50/2 MG Tablet 10
Promexy Hf 50/2 MG Tablet 10
Gujarat Terce Laboratories Ltd
Pack of 10 Units
₹11.83
MRP ₹14.43
18.00% OFF
Relitil Forte 200/2 MG Tablet 10
Relitil Forte 200/2 MG Tablet 10
Reliance Formulation Pvt Ltd
Pack of 10 Units
₹17.22
MRP ₹21.00
18.00% OFF
Chlorotame Forte 200/2 MG Tablet 10
Chlorotame Forte 200/2 MG Tablet 10
Triko Pharmaceuticals
Pack of 10 Units
₹34.44
MRP ₹42.00
18.00% OFF
Emetil Ds 200/2 MG Tablet 10
Emetil Ds 200/2 MG Tablet 10
La Pharmaceuticals
Pack of 10 Units
₹22.92
MRP ₹27.95
18.00% OFF

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