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Chlorthalidone

ANTIHYPERTENSIVE/DIURETICS

Uses of Chlorthalidone

  • Chlorthalidone treats high blood pressure and may also be used to reduce swelling related to heart, kidney, or liver disease.
  • It is a diuretic and anti-hypertensive medicine used to manage hypertension, either as a standalone treatment or in combination with other antihypertensive medications. Chlorthalidone serves as adjunctive therapy for edema associated with conditions such as congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy.
  • Additionally, it has shown efficacy in addressing edema related to various manifestations of renal dysfunction, including nephrotic syndrome and chronic renal failure.

Side effects of Chlorthalidone

  • Vomiting
  • Dizziness
  • Vertigo
  • Headache
  • Nausea
  • Hypotension 

How Chlorthalidone works

  • Chlorthalidone is a prolonged-acting oral diuretic exhibiting antihypertensive properties. This medication induces diuresis, characterised by an increased excretion of sodium and chloride. The diuretic mechanisms of chlorthalidone align with those of benzothiadiazine (thiazide) diuretics, and their maximal effects are comparable. The primary site of action is believed to be the distal convoluted tubule in the nephron. Chlorthalidone's diuretic actions reduce extracellular fluid volume, plasma volume, cardiac output, total exchangeable sodium, glomerular filtration rate, and renal plasma flow.

Certified content

Written By

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Amit SharmaClinical Health & Medical Writer| 3 years

B. Pharm

Reviewed By

Amatul Ameen
Amatul Ameen Clinical Health & Medical Writer| 13 years

B. Pharm, MSc.

Expert Advice

Dosage Forms Available

  • Chlorthalidone is available for use via the oral route (tablets and suspension).

Age and Dose Restrictions

  • Chlorthalidone is meant for adults and children above 18 years of age.

Contraindications

  • Chlorthalidone is contraindicated in patients with known allergies to chlorthalidone, heart issues and phaeochromocytoma.

Other Medications To Avoid With This Medicine

  • It is advisable to avoid the use of medications that lower blood pressure (such as metoprolol, ramipril, hydrochlorothiazide, or atorvastatin), medications for erectile dysfunction (sildenafil), antiepileptic medications (carbamazepine, phenobarbital), immunosuppressants (cyclosporine), and analgesics (ibuprofen, aspirin), among others. Before using any prescription or over-the-counter medications, consultation with your doctor is essential.

Overdose and Missed Dose

  • Overdose of this medicine can cause nausea, weakness, dizziness and disturbances of electrolyte balance, inform your doctor and follow the advice accordingly.
  • If you forget to take this medicine, take it as soon as you remember. But avoid repeating the dose.

Use In Driving And Operating Machinery

  • This medicine does not affect your ability to drive or operate heavy machinery.

Use in Pregnancy and Lactation

  • This medicine is not recommended during pregnancy or breastfeeding.

Special Dietary & Lifestyle Recommendation

  • Avoid alcohol when you are taking Chlorthalidone.
  • Chlorthalidone can be taken after meals.
  • Chlorthalidone usage may precipitate a sudden decrease in blood sodium levels. The concomitant use of this medication with a low-sodium diet may lead to severe side effects.
  • Individuals with hypertension and coronary artery disease should consider lifestyle modifications, including dietary changes such as a low-sodium, low-carbohydrate, and low-fat diet. Regular exercise, like brisk walking for at least 30 minutes daily, five days a week, is also recommended to control blood pressure.
  • Patients with hypertension are at a continuous risk of heart attacks and strokes. Hence, it is vital to establish a routine for monitoring blood pressure through a digital blood pressure monitoring device at home or regular visits to the doctor.
  • Proper education on recognising the signs and symptoms of heart attacks and strokes is essential. This knowledge can lead to quicker interventions, minimising complications and ultimately promoting a faster and more complete recovery.

Frequently asked questions

This medicine starts showing its effects within a few hours after consumption.

Avoid usage if you experience an allergic reaction (hypersensitivity) to Chlorthalidone. It is advisable to seek advice from a doctor promptly.

Do not stop taking this medicine without consulting your doctor, even if you feel healthy.

Consult your doctor before taking this medicine if you have kidney or liver issues to ensure its safety and proper dosage.

No, this medicine does not affect contraception.

Terms & Conditions


Available medicines for CHLORTHALIDONE
Chlornol 12.5 Tablet 10
Chlornol 12.5 Tablet 10
Knoll Healthcare Pvt. Ltd.
Pack of 10 Units
₹24.45
MRP ₹49.00
50.10% OFF
Lupiclor 12.5 Tablet 15
Lupiclor 12.5 Tablet 15
Lupin Ltd
Pack of 15 Units
₹105.74
MRP ₹128.95
18.00% OFF
Thaloric 6.25 Tablet 10
Thaloric 6.25 Tablet 10
Zuventus Healthcare Ltd
Pack of 10 Units
₹44.57
MRP ₹54.35
18.00% OFF
Chlornol 6.25 Tablet 10
Chlornol 6.25 Tablet 10
Knoll Healthcare Pvt. Ltd.
Pack of 10 Units
₹22.45
MRP ₹45.00
50.10% OFF
Ctd 12.5 Tablet 15
Ctd 12.5 Tablet 15
Ipca Laboratories Pvt Ltd.
Pack of 15 Units
₹118.98
MRP ₹145.10
18.00% OFF
New Ch 12.5 Tablet 10
New Ch 12.5 Tablet 10
Systopic Laboratories Private Limited
Pack of 10 Units
₹20.50
MRP ₹25.00
18.00% OFF
Ctd 6.25 Tablet 15
Ctd 6.25 Tablet 15
Ipca Laboratories Pvt Ltd.
Pack of 15 Units
₹92.74
MRP ₹113.10
18.00% OFF
New Ch 6.25 Tablet 10
New Ch 6.25 Tablet 10
Systopic Laboratories Private Limited
Pack of 10 Units
₹13.53
MRP ₹16.50
18.00% OFF

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