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Ciclesonide + Formoterol Fumarate + Tiotropium

Uses of Ciclesonide + Formoterol Fumarate + Tiotropium

  • Ciclesonide + Formoterol Fumarate + Tiotropium is primarily used for the long-term management of COPD, and it belongs to the group of inhaled corticosteroids, LABAs, and LAMAs.

Side effects of Ciclesonide + Formoterol Fumarate + Tiotropium

  • Headache

  • Sinusitis

  • Back pain

  • Oral thrush

  • Pharyngitis

How Ciclesonide + Formoterol Fumarate + Tiotropium works

  • Ciclesonide + Formoterol Fumarate + Tiotropium is a combination composed of an inhaled corticosteroid, a long-acting beta2-adrenergic agonist (LABA), and a long-acting muscarinic antagonist (LAMA).

  • Ciclesonide, an inhaled corticosteroid, works by binding to glucocorticoid receptors in the body. This stops the release of certain chemicals that cause swelling and mucus production in the airways, thus reducing inflammation.

  • Formoterol Fumarate is a LABA. It stimulates beta2-adrenergic receptors in the lungs, which relaxes and opens up the airways, making it easier for you to breathe.

  • Tiotropium, a LAMA, blocks acetylcholine's action, a chemical messenger involved in muscle contraction. This prevents tightening of the muscles around your airways, leading to more relaxed and open airways.

  • Combined together, these three components work in different but complementary ways to effectively open the airways, reduce inflammation, and improve breathing in people with chronic obstructive pulmonary disease (COPD).

Certified content

Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Ciclesonide + Formoterol Fumarate + Tiotropium is available as an inhalation aerosol in a metered dose inhaler.

Age and Dose Restrictions

  • This combination is meant for use in adults.

Contraindications

  • This combination is contraindicated in patients with severe hypersensitivity to milk proteins.

  • It is also contraindicated in patients with hypersensitivity to any of its active components.

Other Medications to Avoid

  • This combination may interact with other LABAs or LAMA (such as salmeterol, indacaterol), corticosteroids (like budesonide, fluticasone), strong CYP3A4 inhibitors (such as ketoconazole, itraconazole), beta-blockers (like propranolol, metoprolol), diuretics (such as furosemide, hydrochlorothiazide), monoamine oxidase inhibitors, and tricyclic antidepressants (including phenelzine, amitriptyline).

Overdose and Missed Dose

  • An overdose of this combination may lead to symptoms such as rapid heartbeat, tremors, dry mouth, or dizziness. If you suspect an overdose, it is vital to seek immediate medical attention.

  • If you forget a dose of this combination, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this combination. However, if you experience any severe side effects or worsening symptoms, please consult your doctor.

  • Ensure adequate hydration by drinking plenty of water to manage dry mouth or throat irritation.

  • Practise good oral hygiene by rinsing your mouth after inhalation to reduce the risk of oral candidiasis.

  • If experiencing dysphonia or hoarseness of voice, resting your voice can help alleviate the symptoms.

Use in Driving and Operating Machinery

  • Ciclesonide + Formoterol Fumarate + Tiotropium has no known effects that impair the ability to drive or operate heavy machinery. However, if you experience dizziness or blurry vision after using the inhaler, avoid engaging in these activities until these effects subside.

Use in Pregnancy and Lactation

  • The safety of this combination during pregnancy and lactation has not been established. It should be used during pregnancy only if clearly needed and under a doctor's supervision. Consult your doctor before using this medication if you are breastfeeding.

Caution in Other Conditions

  • Patients with pre-existing conditions such as narrow-angle glaucoma, urinary retention issues, severe renal impairment, or seizure disorders should use Ciclesonide + Formoterol Fumarate + Tiotropium with caution. These conditions may exacerbate certain side effects or interact adversely with the medication's mechanism.

Special Dietary and Lifestyle Recommendations

  • Maintain hydration to help thin mucus for easier clearance from the airways.

  • Avoid exposure to airborne irritants such as smoke, pollution, and strong fumes, which can exacerbate COPD symptoms.

  • Practice breathing exercises such as pursed-lip breathing that help manage shortness of breath during activities.

Frequently asked questions

No, there is no evidence to suggest that this combination affects mood or hormonal balance. However, everyone reacts differently to medication. If you experience unusual mood changes while taking this medicine, consult your doctor.

While some patients may find relief from symptoms through lifestyle changes or natural remedies, such as special diets or herbal supplements, these are not substitutes for prescribed medication. Always consult your doctor before making any changes to your treatment plan.

No, it does not cause physical or psychological dependency. It is a prescription medication used for the long-term management of COPD.

It is administered as an inhaler and does not contain any animal-derived ingredients. However, it is always best to consult your doctor or pharmacist to confirm.

While using this combination, your doctor may recommend regular check-ups to monitor your response to the treatment and adjust the dosage if needed. This can also help detect any potential side effects early.

It is administered via an inhaler and hence, its effectiveness is not affected by food intake. Please follow your doctor's instructions on when and how to use the medication.

It is not known to interact with any specific foods. However, if you have a severe allergy, particularly to milk proteins, you should inform your doctor, as some inhalers may contain lactose.

Terms & Conditions


Available medicines for CICLESONIDE + FORMOTEROL FUMARATE + TIOTROPIUM
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Trimium Transhaler 180mdi
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Triohale 200/6/9 MCG Multihaler 30 Mdi
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Trimium Transcaps 15
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Triohale Rotacap 30
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Triohale Inhaler 200mdi
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