Cilastatin + Imipenem
Uses of Cilastatin + Imipenem
Cilastatin + Imipenem is primarily used to manage serious bacterial infections. It belongs to the class of carbapenems antibiotics.
This medicine is indicated for managing various infections caused by susceptible bacteria, including lower respiratory tract infections, urinary tract infections, intra-abdominal infections, gynecologic infections (conditions affecting the vagina and genital tract), bacterial septicemia (blood poisoning), bone and joint infections, skin and skin structure infections and endocarditis (inflammation of the inner lining of the heart chambers and valves).
Side effects of Cilastatin + Imipenem
Pain and inflammation at injection site
Gastrointestinal distress (nausea, vomiting, diarrhoea)
Skin rash and itching
Fever
Dizziness
How Cilastatin + Imipenem works
- Imipenem is a broad-spectrum antibiotic that targets bacterial infections by disrupting the construction of the bacterial cell wall. This destabilizes the bacterial cell, leading to its death and effectively controlling the infection.
- Cilastatin, a renal dehydropeptidase inhibitor, plays a crucial role in protecting imipenem from being degraded by the kidneys. By inhibiting this enzyme, cilastatin ensures that higher concentrations of imipenem remain active in the body, enhancing its effectiveness against the bacteria causing the infection.
Certified content
Written By
BDS, MDS
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
- Cilastatin + Imipenem is available as a sterile powder for intravenous infusion.
Age and Dose Restrictions
- This medication is meant for both adults and children. It should be used in paediatric patients weighing more than 30 kg without any history of renal impairment.
Contraindications
- Cilastatin + Imipenem is contraindicated in patients with known hypersensitivity to any component of the combination.
Other Medications to Avoid
- This combination may interact with other carbapenem antibiotics (e.g., doripenem, meropenem), local anaesthetics (e.g., bupivacaine, etidocaine) and beta-lactam antibiotics (e.g., penicillin, amoxicillin).
Overdose and Missed Dose
- Chances for overdose are less as it is administered by a healthcare professional. However, overdosing on Cilastatin + Imipenem may lead to drooping eyelids and seizures. If you suspect an overdose, seek immediate medical attention. Hemodialysis may be required.
- If you miss a dose of this medicine, consult your healthcare professional for the next dose.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
- Drinking plenty of fluids may help manage gastrointestinal distress such as nausea, vomiting, and diarrhoea.
- Rest and relaxation techniques can help manage central nervous system side effects like dizziness, sleepiness, and confusion.
Use in Driving and Operating Machinery
- This medicine may affect your ability to drive or operate heavy machines. Avoid these activities if you experience dizziness, sleepiness, and confusion after taking this medicine.
Use in Pregnancy and Lactation
- Caution is advised when using Cilastatin + Imipenem during pregnancy. This combination should only be used if absolutely necessary and under the guidance of a healthcare professional. Additionally, since this medication can pass into breast milk, nursing mothers should also use it with caution and only under medical supervision.
Caution in Other Conditions
- Patients with renal impairment should exercise caution while taking this medicine as dosage adjustment may be necessary.
Special Dietary and Lifestyle Recommendations
- Maintaining a balanced diet can help improve general health and boost the immune system which is beneficial when dealing with infections.
Frequently asked questions
Is Cilastatin + Imipenem a steroid?
No, Cilastatin + Imipenem is not a steroid. It is an antibiotic combination used to manage serious bacterial infections.
Will Cilastatin + Imipenem affect fertility?
There is no known effect of Cilastatin + Imipenem on human fertility from the available data. If you have concerns about fertility, consult your doctor.
Is it safe to take Cilastatin + Imipenem daily?
Cilastatin + Imipenem should be taken as per your doctor’s recommendation.
How much time does Cilastatin + Imipenem take to work?
The time taken by Cilastatin + Imipenem to work may vary depending on the type and severity of infection.
What is the best time to take Cilastatin + Imipenem
Cilastatin + Imipenem should be administered as advised by your doctor.
How does Cilastatin + Imipenem affect mood?
Cilastatin + Imipenem is not known to affect mood. However, if you experience abnormal mood changes while taking this medicine, consult with your doctor.
Can I take Cilastatin + Imipenem without a meal?
There is no specific guideline about taking Cilastatin + Imipenem with or without food. It is best to follow your doctor's instructions on how to take this medicine.
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