Burning or stinging sensation at the application site
Skin dryness or cracking
Irritation at the application site
Hypopigmentation of skin
Folliculitis
Clobetasol + Gentamicin is a combination of a potent topical corticosteroid and an aminoglycoside antibiotic.
Clobetasol, the corticosteroid component, reduces inflammation and itching. It does this by decreasing the production of inflammatory chemicals in the skin, suppressing the immune response that leads to inflammation, and constricting blood vessels to reduce redness and swelling.
The antibiotic component, Gentamicin, prevents or manages bacterial skin infections. It does this by binding to bacterial ribosomes to inhibit protein synthesis, changing cell membrane permeability, and causing misreading of mRNA leading to faulty protein synthesis. This hampers bacterial growth and replication, leading to bacterial cell death. Together, these components manage inflammatory skin conditions susceptible to bacterial infections.
BDS, MDS
BMS, FMC, MD Resident
Clobetasol + Gentamicin is available as a topical cream, ointment, lotion, and gel. These formulations are to be applied directly to the affected skin areas.
This medication is meant for use by both adults and children, though caution is advised when it is used on younger patients due to increased absorption rates that could lead to higher systemic effects.
Clobetasol + Gentamicin is contraindicated in patients with hypersensitivity to clobetasol, gentamicin, or any of the excipients.
It should not be used by individuals with skin infections caused by fungi, viruses, or mycobacteria.
Other contraindications include conditions like acne rosacea and perioral dermatitis.
This combination may interact with NSAIDs (such as ibuprofen and naproxen), CYP3A4 inhibitors (like itraconazole and ritonavir), neuromuscular blocking agents (such as vecuronium and rocuronium), and diuretics (like furosemide).
An overdose of Clobetasol + Gentamicin might result in excessive redness, peeling, and discomfort at the application site. In such instances, wash the area thoroughly with water and discontinue use until speaking with a doctor.
If you forget to apply Clobetasol + Gentamicin at the scheduled time, apply it as soon as you remember unless it is close to the time of your next dose. Do not apply more than what is recommended in an attempt to make up for the missed dose.
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
To manage skin dryness or irritation, consider applying a gentle moisturiser around the area treated with Clobetasol + Gentamicin but not directly mixed with the medication.
If burning or stinging occurs upon application, ensure that the skin is clean and dry before applying; sometimes moisture trapped under the medication can increase discomfort.
As a topical medication, Clobetasol + Gentamicin does not impact the ability to drive or operate heavy machinery.
Clobetasol + Gentamicin falls under Category C for use during pregnancy. It should only be used when needed and under direct advice from a doctor.
For breastfeeding mothers, it may be used with caution. Ensure that the treatment area does not come into direct contact with the infant.
Patients who have diabetes need to monitor their blood glucose levels closely because corticosteroids including Clobetasol can affect blood sugar control.
Continuous long-term use should be monitored for effects like thinning of the skin or adrenal suppression.
Maintain good hygiene around affected skin areas to support recovery from dermatological conditions treated by Clobetasol + Gentamicin.
Wear loose-fitting clothing over affected areas to prevent irritation from rubbing or excessive sweating.
Consider using hypoallergenic products on your skin such as soaps and laundry detergents to avoid further irritation.
Keep hydrated by drinking plenty of water daily which can help maintain skin hydration overall.
Frequently asked questions
Yes, Clobetasol in the combination of Clobetasol + Gentamicin is a potent corticosteroid. It helps in reducing inflammation, redness, and swelling.
No, Clobetasol + Gentamicin is not recommended for treating fungal skin infections. The antibiotic component, Gentamicin, is effective against certain types of bacteria but does not work against fungi.
It is generally advised to avoid using Clobetasol + Gentamicin on the face unless specifically instructed by your doctor. The skin on the face is more delicate and may react differently to this medication.
Children can use Clobetasol + Gentamicin under medical supervision, but caution should be exercised as they are more prone to systemic absorption and adrenal suppression.
There is no recognized risk of dependency or addiction associated with the use of Clobetasol + Gentamicin. However, long-term use should be avoided due to possible side effects.
It is not advisable to abruptly discontinue use of Clobetasol + Gentamicin after prolonged use as it may lead to steroid withdrawal symptoms. Always consult your doctor for advice on stopping this medication.
Patients with diabetes should exercise caution while using Clobetasol + Gentamicin as it may affect blood glucose control. Regular monitoring of blood glucose levels is recommended.
Clobetasol + Gentamicin in other salts
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