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Clobetasone + Gentamicin

Uses of Clobetasone + Gentamicin

  • The primary use of Clobetasone + Gentamicin is to manage bacterial skin infections that are inflamed or itchy. This combination belongs to a group of medicines known as corticosteroids and antibiotics.

  • It may also be employed for the management of infected insect bites or stings, as well as minor skin infections, such as impetigo.

Side effects of Clobetasone + Gentamicin

  • Local burning or stinging

  • Skin dryness or peeling

  • Lightening of skin (hypopigmentation)

  • Inflammation of hair follicles (folliculitis)

  • Skin rash or hives

How Clobetasone + Gentamicin works

  • Gentamicin, an aminoglycoside antibiotic, works by sticking to the 30S subunit of bacterial ribosomes, stopping protein formation. This kills the bacteria, helping clear up infections.

  • Clobetasone is a medium-strength corticosteroid. It reduces inflammation by blocking the release of arachidonic acid from membrane phospholipids. This stops the production of chemicals which cause inflammation and itchiness.

Certified content

Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Clobetasone + Gentamicin is available for use via topical route in the form of cream and ointment.

Age and Dose Restrictions

  • This medicine is meant for adults and children above 2 years of age.

Contraindications

  • This medicine is contraindicated in patients with known allergy to clobetasone, gentamicin, or any component of the formulation. It should not be used in cases of viral skin infections (e.g., herpes, chickenpox, warts), fungal skin infections, skin tuberculosis, skin cancers or precancerous conditions, ulcerated skin, acne rosacea, primary acne, or perioral dermatitis.

Other Medications to Avoid

  • This combination may interact with several medications, including other topical corticosteroids (such as hydrocortisone), topical antibiotics (like neomycin), and antifungal creams (such as clotrimazole).

Overdose and Missed Dose

  • An overdose of Clobetasone + Gentamicin might lead to increased local side effects such as skin thinning, irritation, or hypothalamic-pituitary-adrenal (HPA) axis suppression. In case of a suspected overdose, wiping off the excess medicine and consulting a doctor is advisable.

  • If you forget to apply Clobetasone + Gentamicin, apply it as soon as you remember. However, if it is nearly time for your next dose, skip the missed one and resume your normal dosing schedule. Do not apply extra to make up for a missed dose.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • If you experience local burning or irritation at the application site, consider applying the medicine at a different time of day.

  • To manage dryness or peeling of treated skin, applying a non-medicated moisturiser might help.

Use in Driving and Operating Machinery

  • This medication does not impair your ability to drive or operate heavy machinery.

Use in Pregnancy and Lactation

  • Use of Clobetasone + Gentamicin during pregnancy or lactation should be considered only if the potential benefits justify the potential risks to the fetus or nursing infant. Consult your doctor before using this medicine during these periods.

Caution in Other Conditions

  • Patients with impaired renal function should use Clobetasone + Gentamicin with caution due to the potential risk of nephrotoxicity from gentamicin.

Special Dietary and Lifestyle Recommendations

  • Maintain good hygiene practices to prevent bacterial infections on skin areas where Clobetasone + Gentamicin is applied.

  • Keep the treated areas clean but avoid harsh soaps or detergents which can exacerbate skin irritation.

  • Wear loose-fitting clothing over treated areas to prevent irritation and allow the skin to breathe.

  • Manage stress effectively as it can exacerbate skin conditions like eczema and psoriasis which might require the use of this medication.

  • Ensure adequate hydration which supports overall skin health.

Frequently asked questions

Clobetasone + Gentamicin is primarily prescribed to manage infected skin conditions that are inflamed and itchy, including eczema, dermatitis, and psoriasis. However, it should only be used for other skin ailments if suggested by a doctor.

While some natural remedies may help soothe skin inflammation and itching, they may not be as effective as Clobetasone + Gentamicin in managing bacterial skin infections. Any alternative treatments should be discussed with your doctor.

One of the side effects of Clobetasone + Gentamicin is hypopigmentation, which means it can cause lightening of the skin at the site of application.

It is not recommended to apply Clobetasone + Gentamicin on open wounds or broken skin as it may increase the risk of systemic absorption and potential side effects.

Extensive use of topical corticosteroids like Clobetasone may lead to elevated blood glucose levels. People with diabetes should closely monitor their blood sugar levels when using this medication over large areas or for prolonged periods.

Before applying cosmetics or any other skincare products, it's advisable to consult your doctor to avoid any potential interactions or irritation.

Yes, hypersensitivity reactions like rash or hives can occur with Clobetasone + Gentamicin use. If you experience any allergic reactions, stop using the medication and contact your doctor immediately.

Terms & Conditions


Available medicines for CLOBETASONE + GENTAMICIN
Closol G 0.05/1 % Ointment 20 GM
Closol G 0.05/1 % Ointment 20 GM
P And P Dermaceuticals Pvt Ltd
Pack of 20 GM
₹89.79
MRP ₹109.50
18.00% OFF
Clobegen Cream 20gm
Clobegen Cream 20gm
East West Pharma
Pack of 20 GM
₹64.37
MRP ₹78.50
18.00% OFF
Exel G Skin 0.05/0.1 % Cream 16 GM
Exel G Skin 0.05/0.1 % Cream 16 GM
Ranbaxy Laboratories Ltd
Pack of 16 GM
₹47.15
MRP ₹57.50
18.00% OFF
Bactiderm G 0.5/0.1 % Cream 30 GM
Bactiderm G 0.5/0.1 % Cream 30 GM
Prayas Pharmaceuticals
Pack of 30 GM
₹26.05
MRP ₹31.77
18.00% OFF
Hinate G 0.05/0.1 % Cream 30 GM
Hinate G 0.05/0.1 % Cream 30 GM
Adips Laboratories
Pack of 30 GM
₹44.28
MRP ₹54.00
18.00% OFF
Sterisone G 0.05/0.1 % Cream 15 GM
Sterisone G 0.05/0.1 % Cream 15 GM
Micro Labs Ltd
Pack of 15 GM
₹27.47
MRP ₹33.50
18.00% OFF
Exel G Skin 0.05/0.1 % Cream 10 GM
Exel G Skin 0.05/0.1 % Cream 10 GM
Ranbaxy Laboratories Ltd
Pack of 10 GM
₹5.95
MRP ₹7.25
18.00% OFF

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