Colchicine

Dosage Forms Available

• Colchicine is available as an oral tablet intended for ingestion. It is to be swallowed and can be taken with or without food as per the doctor's advice.

Age and Dose Restrictions

• This medicine is appropriate for use in adults and children 4 years or older.

Contraindications

• Colchicine is contraindicated for patients who have severe kidney or liver disease.

• Patients who are on strong inhibitors of CYP3A4 or P-glycoprotein, and have liver or kidney impairment should also avoid this medication.

Other Medications to Avoid

• Colchicine can interact with antibiotics (such as clarithromycin, erythromycin and telithromycin), antifungals (itraconazole and ketoconazole), HIV medications (atazanavir, indinavir, nelfinavir, ritonavir and saquinavir) and heart medications (diltiazem, verapamil and quinidine).

Overdose and Missed Dose

• An overdose of Colchicine can lead to severe symptoms like nausea, vomiting, diarrhoea, abdominal pain, muscle weakness, and organ failure. It is essential to seek immediate medical attention if an overdose is suspected.

• If you forget to take your dose of Colchicine, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose. Do not take two doses at once.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• Drinking plenty of fluids can help manage some of the gastrointestinal side effects such as diarrhoea and nausea.

• Resting and avoiding heavy physical activity can lessen muscle pain or weakness.

Use in Driving and Operating Machinery

• Colchicine may cause dizziness or fatigue in some patients. It is advised to avoid driving or operating heavy machinery if you experience these side effects.

Use in Pregnancy and Lactation

• Colchicine is not recommended for use in pregnant women unless the benefits outweigh the risks.

• This medicine may pass into breast milk. Nursing mothers should consult their doctor before using Colchicine.

Caution in Other Conditions

• Patients with kidney or liver disease need to exercise caution when taking Colchicine. Dosage adjustment may be necessary based on the degree of impairment.

• Individuals with a history of stomach disorders should also take this medication with caution.

Special Dietary and Lifestyle Recommendations

• Maintain a healthy weight: Being overweight can increase the risk of gout.

• Be physically active: Regular physical activity can help maintain a healthy weight and reduce the risk of gout attacks.

• Avoid foods high in purines: Foods high in purines, such as red meat and seafood, can increase uric acid levels in the body. Try to limit these foods to prevent gout attacks.