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Dapagliflozin

ANTIDIABETIC

Uses of Dapagliflozin

  • Dapagliflozin is an anti-diabetic medicine that controls blood sugar for type 2 diabetes (T2DM) patients.
  • It can be used as a single treatment or combined with metformin, sulfonylurea, metformin and sulfonylurea, sitagliptin, and insulin.
  • It also reduces the risk of heart failure in patients with T2DM.

Side effects of Dapagliflozin

  • Headache
  • Diarrhea
  • Sore throat
  • Stuffy or runny nose
  • Flu (fever, tiredness, body aches)
  • Constipation
  • Joint pain
  • Rash

How Dapagliflozin works

  • Dapagliflozin acts as an SGLT2 inhibitor, reducing glucose reabsorption and lowering the renal threshold for glucose. Consequently, it enhances urinary glucose excretion. Dapagliflozin also diminishes sodium reabsorption, augmenting the delivery of sodium to the distal tubule. These mechanisms may impact various physiological functions, including but not limited to reducing both pre- and afterload of the heart and downregulating sympathetic activity.

Certified content

Written By

docImg
Amit SharmaClinical Health & Medical Writer| 3 years

B. Pharm

Reviewed By

Amatul Ameen
Amatul Ameen Clinical Health & Medical Writer| 13 years

B. Pharm, MSc.

Expert Advice

Dosage Forms Available

  • This medicine is available for use via the oral route (tablets).

Age and Dose Restrictions

  • This medicine is meant for adults and children above 18 years of age.

Contraindications

  • Dapagliflozin is contraindicated in patients with known allergies to dapagliflozin and who have diabetic ketoacidosis and type 1 diabetes.

Other Medications To Avoid With This Medicine

  • Dapagliflozin interacts with diuretics (such as furosemide, amiloride, hydrochlorothiazide), muscle relaxants (like baclofen), medications for enlarged prostate (such as tamsulosin), antiparkinson's drugs (like levodopa), antibiotics (such as gatifloxacin), heart-related medications (including amlodipine, bisoprolol), and other antidiabetic medications (like glipizide, glimepiride).

Overdose and Missed Dose

  • In case of an overdose of this medicine, inform your doctor and follow the advice accordingly.
  • If you forget to take this medicine, take it as soon as you remember, but avoid repeating the dose.

Use In Driving And Operating Machinery

  • This medicine may affect your ability to drive or operate heavy machinery. Avoid driving if you feel dizzy after taking it.

Use in Pregnancy and Lactation

  • Dapagliflozin is not recommended during pregnancy or breastfeeding.

Special Dietary & Lifestyle Recommendation

  • Avoid alcohol when you are taking Dapagliflozin.
  • Making lifestyle changes, including dietary modifications and regular exercise, is essential when taking Dapagliflozin to control blood sugar levels properly.
  • Following the commencement of Dapagliflozin therapy, it is advisable to undergo blood glucose level reassessment at the 15-day mark and subsequently at regular intervals, typically every 3-6 months. This monitoring evaluates the T2DM progression and facilitates any necessary dose adjustments.
  • In the event of hypoglycemia, it is crucial to have a rapid source of sugar easily accessible. Carry sugar candies, glucose tablets, or sugary foods and drinks devoid of fat or protein, such as fruit juice, to promptly address episodes of low blood sugar.

Frequently asked questions

This medicine starts showing its effects within a few hours after consumption.

Avoid usage if you experience an allergic reaction (hypersensitivity) to this medicine. 

Do not stop taking this medicine without consulting your doctor, even if you feel healthy.

Consult your doctor before taking this medicine if you have kidney or liver issues to ensure its safety and proper dosage.

No, this medicine does not affect contraception.

Terms & Conditions


Available medicines for DAPAGLIFLOZIN
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