Dapagliflozin + Glimepiride + Metformin

Dosage Forms Available

• Dapagliflozin + Glimepiride + Metformin is available for oral use in the form of tablets.

Age and Dose Restrictions

• This combination is indicated for use in adults only. It is not recommended for use in children or adolescents.

Contraindications

This medicine is contraindicated in patients with:

• Known severe hypersensitivity to Dapagliflozin, Glimepiride or Metformin

• Severe renal impairment or are on dialysis

• Acute or chronic metabolic acidosis, including diabetic ketoacidosis

Other Medications to Avoid

• This combination may interact with diuretics (e.g., furosemide, thiazides), insulin or insulin secretagogues (e.g., nateglinide), carbonic anhydrase inhibitors (e.g., acetazolamide), and blood pressure medications (e.g., bosentan).

Overdose and Missed Dose

• An overdose of this medicine may cause symptoms such as nausea, vomiting, diarrhoea, stomach pain, and lactic acidosis. If you observe any of these symptoms, contact your doctor immediately.

• If you forget to take a dose of this medicine, take it as soon as you remember. However, if it is time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• Drinking plenty of fluids may help manage some side effects such as dry mouth or dehydration.

• Taking this medication with food may reduce gastrointestinal side effects like nausea or diarrhoea.

Use in Driving and Operating Machinery

• This medicine may cause lightheadedness or dizziness. Therefore, caution is advised while driving or operating heavy machinery.

Use in Pregnancy and Lactation

• This medicine is not recommended for use during pregnancy or breastfeeding unless absolutely necessary and the benefits outweigh the risks. It is advised to consult your doctor before using this medicine during pregnancy and breastfeeding.

Caution in Other Conditions

• Caution should be exercised when taking this medicine if you have a history of kidney disease, liver disease, heart disease, or pancreatitis.

Special Dietary and Lifestyle Recommendations

• Maintain a balanced diet that is low in sugar and high in fibre to help manage blood sugar levels.

• Regular physical exercise can help control your blood sugar levels and improve overall health.

• Avoid excessive alcohol consumption as it may increase your risk of lactic acidosis.

• Consistently monitor your blood sugar levels as directed by your doctor.

• Regularly check your kidney function while taking this medicine.