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Dapagliflozin + Glimepiride + Metformin

Uses of Dapagliflozin + Glimepiride + Metformin

  • Dapagliflozin + Glimepiride + Metformin is an antidiabetic medicine used to treat diabetes. Its primary use is to manage blood sugar levels in adults with type 2 diabetes mellitus. 
  • This combination belongs to a group of antidiabetic medications and helps manage this chronic condition that affects the body's metabolism of glucose or blood sugar, making it an effective option for individuals with diabetes.

Side effects of Dapagliflozin + Glimepiride + Metformin

  • Urinary tract infections

  • Headache

  • Nausea

  • Diarrhoea

  • Back pain

How Dapagliflozin + Glimepiride + Metformin works

  • Dapagliflozin + Glimepiride + Metformin is a triple-action medication for managing blood sugar levels in type 2 diabetes.

  • Dapagliflozin is a sodium-glucose co-transporter 2 inhibitor. It stops a protein in the kidneys from absorbing glucose back into the blood, thus helping to remove excess sugar from the body via urine.

  • Glimepiride is a sulfonylurea. It encourages the pancreas to produce more insulin, a hormone that aids in the uptake of sugar from the blood by body cells, reducing overall blood sugar levels.

  • Metformin is a biguanide. It reduces the amount of sugar made by the liver, decreases the absorption of sugar from food in the gut, and improves insulin sensitivity so your body utilises the insulin it produces more effectively.

  • Together, these three components work on different parts of your body to control and reduce blood sugar levels more effectively.

Certified content

Written By

docImg
Ashmita BorgohainMedical Content Writer & Editor| 12 years

MSc (Applied Genetics)

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Dapagliflozin + Glimepiride + Metformin is available for oral use in the form of tablets.

Age and Dose Restrictions

  • This combination is indicated for use in adults only. It is not recommended for use in children or adolescents.

Contraindications

This medicine is contraindicated in patients with:

  • Known severe hypersensitivity to Dapagliflozin, Glimepiride or Metformin

  • Severe renal impairment or are on dialysis

  • Acute or chronic metabolic acidosis, including diabetic ketoacidosis

Other Medications to Avoid

  • This combination may interact with diuretics (e.g., furosemide, thiazides), insulin or insulin secretagogues (e.g., nateglinide), carbonic anhydrase inhibitors (e.g., acetazolamide), and blood pressure medications (e.g., bosentan).

Overdose and Missed Dose

  • An overdose of this medicine may cause symptoms such as nausea, vomiting, diarrhoea, stomach pain, and lactic acidosis. If you observe any of these symptoms, contact your doctor immediately.

  • If you forget to take a dose of this medicine, take it as soon as you remember. However, if it is time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • Drinking plenty of fluids may help manage some side effects such as dry mouth or dehydration.

  • Taking this medication with food may reduce gastrointestinal side effects like nausea or diarrhoea.

Use in Driving and Operating Machinery

  • This medicine may cause lightheadedness or dizziness. Therefore, caution is advised while driving or operating heavy machinery.

Use in Pregnancy and Lactation

  • This medicine is not recommended for use during pregnancy or breastfeeding unless absolutely necessary and the benefits outweigh the risks. It is advised to consult your doctor before using this medicine during pregnancy and breastfeeding.

Caution in Other Conditions

  • Caution should be exercised when taking this medicine if you have a history of kidney disease, liver disease, heart disease, or pancreatitis.

Special Dietary and Lifestyle Recommendations

  • Maintain a balanced diet that is low in sugar and high in fibre to help manage blood sugar levels.

  • Regular physical exercise can help control your blood sugar levels and improve overall health.

  • Avoid excessive alcohol consumption as it may increase your risk of lactic acidosis.

  • Consistently monitor your blood sugar levels as directed by your doctor.

  • Regularly check your kidney function while taking this medicine.

Frequently asked questions

No, Dapagliflozin + Glimepiride + Metformin is not a steroid. It is a combination medicine used to manage type 2 diabetes mellitus and comprises three active ingredients each belonging to different classes of antidiabetic medications: Dapagliflozin (SGLT2 inhibitor), Glimepiride (sulfonylurea), and Metformin (biguanide).

There are no direct reports suggesting that combination medicine negatively impacts sleep. However, it is essential to maintain a regular sleep pattern for optimal diabetes management.

There is no clear evidence suggesting that this combination medicine impacts fertility. However, if planning to conceive or during pregnancy, you should consult your doctor for appropriate diabetes management plans.

This medication is most effective when used as part of an overall diabetes management plan, which includes a healthy diet. It is not associated with any specific dietary restrictions but maintaining balanced meals helps in controlling blood sugar levels.

Yes, it is safe to take Dapagliflozin + Glimepiride + Metformin daily as recommended by your doctor. The medicine should be taken regularly to get maximum benefits.

The time required for this medicine to show its effect may vary among individuals. However, blood glucose levels generally start to decrease within a couple of days after starting the medicine.

This medicine is generally recommended to be taken at the same time every day. Always follow your doctor's advice regarding the timing of medication to benefit from the efficacy of the medication.

Terms & Conditions


Dapagliflozin + Glimepiride + Metformin in other salts

DAPAGLIFLOZINDAPAGLIFLOZIN + METFORMINGLICLAZIDE + METFORMINGLIMEPIRIDEGLIMEPIRIDE + METFORMINGLIMEPIRIDE + METFORMIN + PIOGLITAZONEGLIMEPIRIDE + METFORMIN + VOGLIBOSELINAGLIPTIN + METFORMINMETFORMINMETFORMIN + SITAGLIPTINMETFORMIN + VILDAGLIPTINMETFORMIN + VOGLIBOSEMETFORMIN + TENELIGLIPTINMETFORMIN + MYO INOSITOLGLIMEPIRIDE + PIOGLITAZONEMETFORMIN + PIOGLITAZONEGLIBENCLAMIDE + METFORMINGLIPIZIDE + METFORMINALPHA LIPOIC ACID + METFORMINMETFORMIN + METHYLCOBALAMINGLICLAZIDE + METFORMIN + PIOGLITAZONEGLICLAZIDE + METFORMIN + VOGLIBOSEMETFORMIN + PIOGLITAZONE + VOGLIBOSEGLIBENCLAMIDE + METFORMIN + PIOGLITAZONEGLIBENCLAMIDE + METFORMIN + ROSIGLITAZONEACARBOSE + METFORMINATORVASTATIN + GLIMEPIRIDE + METFORMINMETFORMIN + ROSIGLITAZONEMETFORMIN + REPAGLINIDED CHIRO INOSITOL + L-METHYLFOLATE + METFORMIN + METHYLCOBALAMIN + MYO INOSITOLEMPAGLIFLOZIN + METFORMINMETFORMIN + NATEGLINIDEATORVASTATIN + METFORMINMETFORMIN + SAXAGLIPTINGLIMEPIRIDE + METFORMIN + ROSIGLITAZONEMETFORMIN + REMOGLIFLOZIN ETABONATEALOGLIPTIN + METFORMINMETFORMIN + REMOGLIFLOZIN ETABONATE + VILDAGLIPTINDAPAGLIFLOZIN + VILDAGLIPTINDAPAGLIFLOZIN + SITAGLIPTINDAPAGLIFLOZIN + METFORMIN + SITAGLIPTINDAPAGLIFLOZIN + TENELIGLIPTINDAPAGLIFLOZIN + METFORMIN + VILDAGLIPTINDAPAGLIFLOZIN + LINAGLIPTINGLIMEPIRIDE + METFORMIN + SITAGLIPTINMETFORMIN + MYO-INOSITOL / INOSITOLMETFORMIN + PIOGLITAZONE + SITAGLIPTINMETFORMIN + PIOGLITAZONE + TENELIGLIPTINDAPAGLIFLOZIN + LINAGLIPTIN + METFORMIN
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