Diazepam

Dosage Forms Available

• Diazepam can be taken orally (tablet and oral solution), administered intravenously or intramuscularly (injection), and applied topically to the rectum (gel).

Age and Dose Restrictions

• Diazepam is primarily meant for adults. Its safety and efficacy are not established for children under six months of age.

Contraindications

• Diazepam is contraindicated in patients with known hypersensitivity to benzodiazepines. It should not be used in patients with acute narrow-angle glaucoma or severe respiratory insufficiency. Patients with severe hepatic impairment or sleep apnea syndrome should also avoid this medicine.

Other Medications to Avoid

• Diazepam may interact with other central nervous system depressants like barbiturates (such as, phenobarbital), antipsychotics (like olanzapine), opioids (such as morphine), sedative antihistamines (like diphenhydramine), CYP2C19 and CYP3A4 inhibitors (such as erythromycin and ritonavir), and inducers (like rifampin and phenytoin).

Overdose and Missed Dose

• Overdosing on Diazepam can lead to symptoms like somnolence, confusion, diminished reflexes and respiratory depression. If you observe these symptoms, inform your doctor immediately.

• In case you miss a dose, take it as soon as you remember. But if it is closer to the time for your next dose, skip the missed dose and get back to your regular schedule. Do not double the dose.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• If you experience drowsiness or fatigue after taking Diazepam, try taking it before bedtime.

• If you feel dizzy or unsteady after taking Diazepam, avoid sudden changes in position. Rise slowly from sitting or lying down.

• Drinking an adequate amount of water can help manage gastrointestinal disturbances like constipation or nausea caused by Diazepam.

Use in Driving and Operating Machinery

• Diazepam may cause drowsiness, dizziness, and problems with coordination, which could affect your ability to drive or operate machinery. It is advised to refrain from such activities while taking this medication.

Use in Pregnancy and Lactation

• Diazepam is not recommended for use during pregnancy and breastfeeding due to potential risks. It is advised to consult a doctor before using this medicine if you are pregnant or breastfeeding.

Caution in Other Conditions

• Diazepam should be used with caution in patients with impaired renal or hepatic function. Patients with a history of medicine or alcohol addiction should use Diazepam cautiously due to its potential for abuse and dependence.

Special Dietary and Lifestyle Recommendations

• Engage in stress-management activities such as yoga, meditation, or mindfulness exercises to better manage anxiety disorders for which Diazepam is prescribed.

• Follow a regular sleep schedule to improve symptoms of insomnia.