Diclofenac + Paracetamol/acetaminophen + Trypsin-chymotrypsin

Dosage Forms Available

• Diclofenac + Paracetamol/Acetaminophen + Trypsin-Chymotrypsin is available for use via the oral route in the form of enteric-coated tablets.

Age and Dose Restrictions

• This medicine is meant for adults and children above 12 years of age.

Contraindications

• This medicine is contraindicated in patients with known hypersensitivity to any ingredient.

• This medicine is contraindicated in patients with active peptic ulcer disease or gastrointestinal bleeding.

• This medicine is contraindicated in patients with severe liver or kidney impairment.

• This medicine is contraindicated in patients with a history of asthma, urticaria, or allergic reactions to NSAIDs.

Other Medications to Avoid

• This combination may interact with anticoagulants (such as warfarin and heparin), SSRIs (like sertraline, and fluoxetine), corticosteroids (including prednisone and dexamethasone), diuretics (such as furosemide and hydrochlorothiazide), ACE inhibitors (like enalapril and lisinopril), ARBs (such as losartan and valsartan), methotrexate, cyclosporine, lithium, aspirin, and other NSAIDs (like ibuprofen, naproxen).

Overdose and Missed Dose

• An overdose of this medicine may cause nausea, vomiting, abdominal pain, drowsiness, hypotension, or hepatorenal damage. There is no specific antidote; treatment is symptomatic and supportive. Activated charcoal may be used within 1-2 hours of ingestion.

• If you miss a dose of this medicine, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• To manage nausea or dyspepsia, consider taking the medicine with meals or adjusting meal times relative to when you take the medication.

• If experiencing mild headaches or dizziness, ensure adequate hydration by drinking sufficient water throughout the day.

Use in Driving and Operating Machinery

This medication may affect your ability to drive or operate heavy machinery. Avoid driving if you feel dizzy or sleepy after taking this medicine.

Use in Pregnancy and Lactation

• This medicine is not recommended during pregnancy, particularly in the third trimester, and while breastfeeding unless advised by your doctor.

• It is advised to consult your doctor before using this medicine during pregnancy and lactation.

Caution in Other Conditions

• Patients with mild to moderate hepatic impairment should use this medicine cautiously and at the lowest effective dose.

• Caution is advised for patients with renal impairment; avoid using this medicine in cases of severe renal failure.

Special Dietary and Lifestyle Recommendations

• Maintain a balanced diet rich in vegetables, fruits, whole grains, and lean proteins to support overall health and potentially reduce inflammation associated with musculoskeletal conditions.

• Engage in regular physical activity such as walking, swimming, or yoga to strengthen muscles around the joints and improve flexibility without excessive strain.

• Consider incorporating omega-3 fatty acids found in fish like salmon or through supplements, as they can help reduce inflammation.

• Maintain adequate hydration by drinking plenty of water throughout the day to help manage medication side effects such as dizziness or headaches.

• Avoid foods that can aggravate inflammation such as refined sugars, dairy products high in fat, and red meat; opt instead for anti-inflammatory foods like turmeric, ginger, berries, nuts, and green leafy vegetables.

• Practice stress-relief techniques such as meditation or deep-breathing exercises which can help manage pain perception related to chronic conditions like arthritis.