Diclofenac + Rabeprazole

Dosage Forms Available

• Diclofenac + Rabeprazole is available for oral use in the form of tablets.

Age and Dose Restrictions

• This medicine is intended for use by adults only. It is not meant for children under any circumstances.

Contraindications

• Diclofenac + Rabeprazole is contraindicated in patients with known hypersensitivity to any of its components.

• It should not be used by individuals with severe liver or kidney disease.

• Patients with active gastric or duodenal ulcers should avoid this medicine.

• It is contraindicated for those with congestive heart failure (NYHA Class II-IV).

• Patients with a history of asthma, urticaria, or allergic reactions to aspirin or other NSAIDs should not use this medication.

Other Medications to Avoid

• This combination may interact with lithium (such as lithium carbonate), digoxin (like Lanoxin), methotrexate (such as Rheumatrex), cyclosporine (including Sandimmune), tacrolimus (like Prograf), diuretics (such as furosemide and hydrochlorothiazide), RAAS inhibitors (like lisinopril and losartan), ketoconazole, atazanavir, iron salts, erlotinib, CYP2C19/3A4 inhibitors (such as fluconazole, clarithromycin, voriconazole), and CYP2C19/3A4 inducers (like rifampin, carbamazepine, and St. John's wort).

Overdose and Missed Dose

• Symptoms of overdose may include lethargy, nausea, vomiting, gastrointestinal bleeding, seizures, coma, liver dysfunction, acute renal failure, metabolic acidosis, and respiratory depression. In such cases, immediate medical attention is crucial.

• If you miss a dose of Diclofenac + Rabeprazole, take it as soon as you remember unless it is close to the time for your next dose. In that case, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• To manage gastrointestinal side effects like dyspepsia or abdominal pain, consider taking the tablet with a small amount of food.

• Drinking sufficient water may help alleviate side effects such as dry mouth or constipation.

Use in Driving and Operating Machinery

Diclofenac + Rabeprazole may cause side effects such as dizziness or somnolence that could affect your ability to drive or operate machinery. You should avoid these activities if you experience these symptoms.

Use in Pregnancy and Lactation

• Diclofenac + Rabeprazole is not recommended during pregnancy or lactation. If you are pregnant or breastfeeding, consult your doctor before using this medication.

Caution in Other Conditions

• Special caution should be exercised when using Diclofenac + Rabeprazole in patients with existing hypertension or heart disease due to the potential worsening of these conditions.

• It should also be used with caution in patients with a history of gastrointestinal diseases such as peptic ulcers due to the increased risk of bleeding.

• Patients with hepatic impairment or renal impairment should consult their doctor for possible dose adjustments.

Special Dietary and Lifestyle Recommendations

• Maintain a balanced diet rich in fruits, vegetables, and whole grains which may help manage inflammation and overall health.

• Limit intake of foods that can exacerbate inflammation such as refined sugars and saturated fats.

• Regular physical activity can help maintain joint mobility and overall physical health but should be moderated according to pain levels.

• Reducing stress through techniques like meditation or yoga could be beneficial in managing symptoms related to rheumatic conditions.

• Smoking cessation is strongly recommended as smoking can deteriorate bone health and exacerbate complications associated with inflammatory diseases.