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Diloxanide + Metronidazole

Uses of Diloxanide + Metronidazole

  • The primary use of Diloxanide + Metronidazole is for the management of certain parasitic and bacterial infections, mainly in the intestines. This medicine belongs to the group of antiprotozoal and antibiotics.

  • This combination is also used for managing intestinal amoebiasis caused by Entamoeba histolytica, amebic liver abscess, giardiasis caused by Giardia lamblia, trichomoniasis and bacterial vaginosis.

Side effects of Diloxanide + Metronidazole

  • Nausea

  • Vomiting

  • Pain in the upper abdomen

  • Diarrhoea

  • Metallic taste in the mouth

How Diloxanide + Metronidazole works

  • Diloxanide + Metronidazole is a potent anti-infective combination.

  • Diloxanide, an antiprotozoal agent, works by interfering with the metabolism and reproduction of amoebas, which are a type of microorganism found in the intestines.

  • Metronidazole is an antibiotic. It selectively targets anaerobic organisms, that lack oxygen for growth and multiplication. It works by inhibiting their DNA synthesis, causing the bacterial cells and certain parasites to die.

  • Together, Diloxanide and Metronidazole work to eliminate harmful parasites and bacteria from the body.

Certified content

Written By

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Dr. Michelle FrankMedical Content Writer| 8 years

Doctor of Medicine

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Diloxanide + Metronidazole is available as tablets, which are taken orally.

Age and Dose Restrictions

  • This combination is meant for both adults and children above 12 years of age.

  • The age and dosage depend on the specific condition being managed and should be determined by a doctor.

Contraindications

  • Diloxanide + Metronidazole is contraindicated in patients with known hypersensitivity to any of its components.

  • It is also contraindicated for individuals with neurological disorders, including epilepsy and multiple sclerosis, due to its potential neurological side effects.

  • Patients with severe liver disease should avoid using this medication, as it can exacerbate their condition.

Other Medications to Avoid

  • This combination may interact with disulfiram (used in alcohol dependency), anticoagulants (like warfarin), antimanic agents (like lithium), anticonvulsants (like phenytoin and phenobarbital) and H2 blockers (like cimetidine).

Overdose and Missed Dose

  • An overdose of this combination might lead to severe nausea, vomiting, unsteady movements (ataxia), seizures and peripheral neuropathy. If an overdose is suspected, consult a doctor immediately.

  • If a dose of this combination is missed, it should be taken as soon as remembered. However, if it is close to the time for the next dose, skip the missed dose and continue with the usual dosing schedule. Do not take a double dose to make up for a missed one.

Management of Side Effects

Most side effects of are temporary and generally harmless. They tend to resolve upon discontinuation of this combination. However, if you experience any severe side effects or worsening of symptoms, please consult your doctor.

  • To manage gastrointestinal side effects like nausea, vomiting, and diarrhoea, try taking the medicine with food.

  • If experiencing dizziness or headaches, ensure adequate hydration by drinking plenty of water throughout the day.

Use in Driving and Operating Machinery

  • Diloxanide + Metronidazole may cause dizziness or weakness. If you experience such symptoms, avoid driving or operating heavy machinery until you feel well enough to do so safely.

Use in Pregnancy and Lactation

  • Caution is advised when using Diloxanide + Metronidazole during pregnancy and lactation. It is important to consult your doctor for guidance based on your specific health conditions and needs during these sensitive periods.

Caution in Other Conditions

  • Patients with renal (kidney) impairment should use this combination with caution. Monitoring of organ function may be necessary when under treatment with this medication.

  • Individuals with pre-existing blood disorders should be closely monitored as the medication can affect blood cell counts.

Special Dietary and Lifestyle Recommendations

  • Practice good hygiene especially handwashing before meals and after using the restroom to prevent the spread of infection.

  • Follow safe sex practices to prevent the spread of diseases such as trichomoniasis and bacterial vaginosis.

Frequently asked questions

No, it is not a steroid. It is a combination of an antiprotozoal medication (Diloxanide furoate) and an antibiotic (Metronidazole).

There is no evidence to suggest that it influences mood or hormonal balances. The combination is primarily aimed at managing amoebic and bacterial infections in the intestines.

There is no evidence to suggest that the use of this combination affects fertility in humans.

Generally, there are no specific foods that interfere with the action of this combination. However, it is advisable to take this medication with food to minimise gastrointestinal side effects.

This is a scientifically developed combination designed to manage specific parasitic and bacterial infections. While maintaining good hygiene and eating a balanced diet can help prevent such infections, there are no known natural alternatives that can replace the effectiveness of this medication.

The time for this combination to start working can vary depending on the type and severity of the infection. However, it usually starts working within a few hours after administration.

Diloxanide + Metronidazole should be taken at the times prescribed by your doctor. It is generally advised to take the medication with food to minimize gastrointestinal side effects.

Terms & Conditions


Available medicines for DILOXANIDE + METRONIDAZOLE
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