Dolutegravir

Expert Advice

Dosage Forms Available

• Dolutegravir is available in tablet form for oral administration. This includes standard tablets and tablets for oral suspension.

Age and Dose Restrictions

• Dolutegravir is suitable for use in adults, adolescents, and children. The medication is prescribed for children weighing at least 3 kg.

Contraindications

• Dolutegravir is contraindicated in patients with a known hypersensitivity to any component of the formulation.

• It is also contraindicated for patients currently receiving dofetilide therapy.

Other Medications to Avoid

• Dolutegravir may interact with antacids (like aluminium or magnesium hydroxide), certain anticonvulsants (such as carbamazepine, and phenytoin), and other antiretrovirals (like efavirenz). These interactions can affect the absorption and effectiveness of the treatment for HIV.

Overdose and Missed Dose

• An overdose of Dolutegravir could potentially exacerbate side effects or lead to new adverse reactions. It is essential to adhere to prescribed dosages and contact a doctor immediately if an overdose is suspected.

• If you miss a dose of Dolutegravir, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• For minor nausea or headache, taking Dolutegravir with food might help or try spacing out doses differently after consulting with your doctor.

• Ensuring adequate hydration may help alleviate minor side effects like dry mouth or dizziness.

Use in Driving and Operating Machinery

• Dolutegravir may cause dizziness or fatigue in some individuals. It is advisable to avoid driving or operating heavy machinery if you experience these symptoms while taking this medication.

Use in Pregnancy and Lactation

• The use of Dolutegravir during pregnancy should be based on a careful consideration of potential benefits and risks. Consultation with a doctor is essential.

• Mothers taking Dolutegravir should not breastfeed due to the potential for HIV transmission and possible adverse effects on the infant.

Caution in Other Conditions

• Individuals with existing liver problems or those co-infected with hepatitis B or C should use Dolutegravir with caution. Regular monitoring by a healthcare provider is recommended.

• Patients with severe hepatic impairment should avoid using this medication due to potential increases in exposure which could lead to more pronounced side effects.

Special Dietary and Lifestyle Recommendations

• Adherence to a balanced diet rich in essential nutrients can support overall health and possibly counteract some minor side effects linked with HIV medications like Dolutegravir.

• Regular physical activity is recommended unless otherwise advised by a doctor, as it can boost immune function and overall well-being.

• Maintaining hydration is especially important when on medications like Dolutegravir, as it helps manage medication-induced fatigue and aids in general detoxification processes.

• Stress management techniques such as mindfulness or yoga might be beneficial, considering the psychological burden associated with chronic conditions like HIV.

Frequently asked questions

Terms & Conditions