Domperidone + Flunarizine + Paracetamol/acetaminophen

Dosage Forms Available

• Domperidone + Flunarizine + Paracetamol/Acetaminophen is available for oral use in the form of tablets and capsules.

Age and Dose Restrictions

• This medicine is intended for use by adults only.

Contraindications

• This combination is contraindicated in patients with hepatic impairment.

• It is also contraindicated in those with cardiac arrhythmias, congestive heart failure, or a prolonged QT interval.

• Additionally, it should not be used by individuals with Parkinson's disease, pheochromocytoma, porphyria, or epilepsy.

Other Medications to Avoid

• This combination may interact with CYP3A4 inhibitors (such as erythromycin, and ketoconazole), calcium channel blockers (like verapamil, and diltiazem), and CNS depressants (such as benzodiazepines).

Overdose and Missed Dose

• An overdose of Domperidone + Flunarizine + Paracetamol/Acetaminophen may lead to severe liver injury, cardiac issues, or nervous system effects such as dizziness and confusion. Immediate medical attention should be sought if an overdose is suspected.

• If a dose is missed, it should be taken as soon as remembered unless it is close to the time for your next dose. In that case, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this combination. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• For drowsiness caused by Flunarizine, consider taking the medication at bedtime to minimise impact during daytime activities.

• If you experience dry mouth from Domperidone, sipping water regularly can help alleviate discomfort.

Use in Driving and Operating Machinery

• Domperidone + Flunarizine + Paracetamol/Acetaminophen may cause drowsiness or dizziness. You should avoid driving or operating heavy machinery until you know how this medicine affects you.

Use in Pregnancy and Lactation

• This combination is contraindicated during pregnancy and lactation. Components like Domperidone have been shown to be excreted in breast milk. The risk of adverse effects on the foetus has also been reported.

• Always consult your doctor before using this medication if you are pregnant or breastfeeding.

Caution in Other Conditions

• Caution is advised when using Domperidone + Flunarizine + Paracetamol/Acetaminophen in elderly patients due to an increased sensitivity to side effects such as drowsiness and cardiac effects.

• Patients with renal impairment must also be cautious; dose adjustments may be necessary to avoid accumulation of the medicine components, which can increase the risk of adverse effects.

Special Dietary and Lifestyle Recommendations

• It is recommended to keep a migraine diary to identify potential food triggers. Common triggers include aged cheeses, red wine, processed meats, and chocolate.

• Stay hydrated throughout the day; dehydration can trigger migraines in some individuals.

• Limit caffeine consumption, as excessive intake can lead to withdrawal headaches, which might mimic or trigger migraines.