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Domperidone + Ranitidine + Simethicone

Uses of Domperidone + Ranitidine + Simethicone

  • Domperidone + Ranitidine + Simethicone is primarily used to manage gastrointestinal issues like heartburn, acidity, bloating, and stomach discomfort. It belongs to the group of gastrointestinal medicines.

  • Additionally, it is also prescribed for the management of Gastroesophageal reflux disease (GERD), Dyspepsia, Peptic ulcers, Functional dyspepsia, and Flatulence.

Side effects of Domperidone + Ranitidine + Simethicone

  • Dry mouth

  • Headache

  • Dizziness

  • Constipation

  • Diarrhoea

How Domperidone + Ranitidine + Simethicone works

  • Domperidone + Ranitidine + Simethicone is a combination medicine that aids in managing gastrointestinal discomfort.

  • Domperidone is a dopamine antagonist. It works by blocking dopamine receptors in the gut and promoting the movement and emptying of the stomach, helping to relieve feelings of fullness, bloating and nausea.

  • Ranitidine is an H2-receptor antagonist. It works to decrease the production of stomach acid by blocking the action of histamine on parietal cells within the stomach lining. Lowering acid levels helps to manage and provide relief from acid reflux, ulcers and heartburn.

  • Simethicone is an anti-foaming agent. It works by reducing the surface tension of gas bubbles in the gut, allowing smaller bubbles to combine into larger ones which are easier to expel as burps or flatulence. This helps to manage and provide relief from gassiness and bloating.

Certified content

Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Domperidone + Ranitidine + Simethicone is available for use in the form of oral tablets.

  • This medicine is taken by mouth, and the tablets must be swallowed whole with a glass of water.

Age and Dose Restrictions

  • This medicine is meant for adults. It is not commonly recommended for children unless specifically prescribed by a doctor.

Contraindications

  • This medicine is contraindicated in patients with known allergies to any of its components (Domperidone, Ranitidine, or Simethicone). It should not be used by patients with a history of stomach bleeding or intestinal obstruction, and it is also contraindicated in individuals with porphyria, a rare blood disorder.

Other Medications to Avoid

  • This combination may interact with several medications, including other gastrointestinal agents such as proton pump inhibitors (like omeprazole), antacids (such as magnesium hydroxide), and medications that affect gastric motility (like metoclopramide).

Overdose and Missed Dose

  • An overdose of Domperidone + Ranitidine + Simethicone might cause symptoms such as confusion, irregular heartbeat, or severe drowsiness. If these occur, it is crucial to seek immediate medical attention.

  • If you miss a dose of this medicine, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed one and resume your usual dosing schedule. You should not double the dose to make up for a missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • To manage a dry mouth, sip water regularly or chew sugar-free gum.

  • For constipation, consider increasing your intake of fibre-rich foods and fluids.

  • If experiencing dizziness, getting up slowly from sitting or lying positions may help.

Use in Driving and Operating Machinery

  • This medication can cause dizziness or drowsiness. If you experience these side effects, you should avoid driving or operating heavy machinery until you feel safe to perform such activities.

Use in Pregnancy and Lactation

  • Domperidone + Ranitidine + Simethicone should only be used during pregnancy or while breastfeeding if needed and recommended by a doctor. It is essential to discuss all potential risks with your doctor before starting this medication.

Caution in Other Conditions

  • Patients with kidney disease need to exercise caution when taking Domperidone + Ranitidine + Simethicone. The doses may need adjustment based on individual health conditions.

  • Individuals with cardiovascular diseases should also use this medicine cautiously due to potential heart-related side effects from domperidone.

Special Dietary and Lifestyle Recommendations

  • Avoid foods that trigger heartburn and acidity such as spicy dishes, citrus fruits, chocolate, and caffeinated beverages.

  • Eating smaller, more frequent meals can help manage symptoms of indigestion

  • Do not lie down immediately after eating; allow some time for digestion.

  • Raising the head of your bed can help reduce nighttime symptoms of acid reflux.

Frequently asked questions

No, Domperidone + Ranitidine + Simethicone does not typically cause any changes in mood. However, everyone reacts differently to medications, so if you notice any unusual mood changes, consult your doctor.

The consumption of alcohol is not recommended while taking this medication as it could increase the risk of stomach irritation and worsen your symptoms. Always consult your doctor before consuming alcohol while on any medication.

It is not recommended to stop taking this medication without consulting your doctor, even if your symptoms improve. The condition being managed might resurface if the treatment course is not completed.

The combination of Domperidone + Ranitidine + Simethicone does not affect male or female fertility.

There is no scientific evidence that suggests that this combination alters menstrual cycles. However, if you notice any irregularities or changes in your cycle after starting this medication, consult your doctor.

This combination should be used with caution in individuals with liver disease as it may affect the metabolism of the medication and lead to an increased risk of side effects. Always inform your doctor about your medical history before starting any new medication.

Your doctor will prescribe the best time to take Domperidone + Ranitidine + Simethicone.

Terms & Conditions


Domperidone + Ranitidine + Simethicone in other salts

ALUMINIUM HYDROXIDE + MAGNESIUM HYDROXIDE (MILK OF MAGNESIA) + SIMETHICONEDOMPERIDONE + OMEPRAZOLEDOMPERIDONE + RABEPRAZOLERANITIDINEDOMPERIDONE + ESOMEPRAZOLEDOMPERIDONENAPROXEN + DOMPERIDONEDEXRABEPRAZOLE + DOMPERIDONEALUMINIUM HYDROXIDE + MAGNESIUM ALUMINIUM SILICATE HYDRATE + MAGNESIUM HYDROXIDE (MILK OF MAGNESIA) + SIMETHICONECINNARIZINE + DOMPERIDONESIMETHICONEDOMPERIDONE + ILAPRAZOLEDOMPERIDONE + LAFUTIDINEDOMPERIDONE + LANSOPRAZOLEALPHA AMYLASE + PAPAIN + SIMETHICONEDOMPERIDONE + RANITIDINEDIASTASE + PEPSIN + SIMETHICONEDICYCLOMINE + SIMETHICONEDILL OIL + FENNEL OIL + SIMETHICONEMAGALDRATE + OXETACAINE + SIMETHICONEMAGALDRATE + SIMETHICONEALUMINIUM HYDROXIDE + MAGNESIUM HYDROXIDE (MILK OF MAGNESIA) + SIMETHICONE + SODIUM CARBOXYMETHYL CELLULOSEALUMINIUM HYDROXIDE + MAGNESIUM HYDROXIDE (MILK OF MAGNESIA) + OXETACAINE + SIMETHICONEALUMINIUM HYDROXIDE + MAGNESIUM HYDROXIDE (MILK OF MAGNESIA) + SIMETHICONE + SORBITOLALUMINIUM HYDROXIDE + MAGNESIUM HYDROXIDE (MILK OF MAGNESIA) + SIMETHICONE + SODIUM ALGINATEONDANSETRON + RANITIDINEDOMPERIDONE + SUCRALFATEMETRONIDAZOLE + OFLOXACIN + SIMETHICONEDOMPERIDONE + MAGALDRATE + SIMETHICONEALUMINIUM HYDROXIDE + LIQUORICE EXTRACT + MAGNESIUM HYDROXIDE (MILK OF MAGNESIA) + SIMETHICONEALGINIC ACID + ALUMINIUM HYDROXIDE + MAGNESIUM HYDROXIDE (MILK OF MAGNESIA) + SIMETHICONEDOMPERIDONE + PARACETAMOL/ACETAMINOPHENDOMPERIDONE + FLUNARIZINE + PARACETAMOL/ACETAMINOPHENDILOXANIDE + SIMETHICONE + TINIDAZOLEDICYCLOMINE + MAGALDRATE + OXETACAINE + SIMETHICONEDICYCLOMINE + RANITIDINEDOMPERIDONE + PARACETAMOL/ACETAMINOPHEN + TRAMADOLCISAPRIDE + SIMETHICONEBILE CONSTITUENTS + PANCREATIN + SIMETHICONEACTIVATED CHARCOAL + SIMETHICONEDICYCLOMINE + MEFENAMIC ACID + SIMETHICONE
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