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Domperidone + Sucralfate

Uses of Domperidone + Sucralfate

  • The primary use of Domperidone + Sucralfate is to manage symptoms of gastrointestinal reflux disease (GERD), which include heartburn, chest pain, and difficulty swallowing. These medicines belong to the class of antiemetic, prokinetic, and gastrointestinal protective agents.

  • They are also used to prevent and manage stomach and duodenal ulcers, as well as to alleviate stomach pain and discomfort.

Side effects of Domperidone + Sucralfate

  • Dry mouth

  • Headache

  • Abdominal cramps

  • Dizziness

  • Constipation

How Domperidone + Sucralfate works

  • Domperidone + Sucralfate is a gastroprotective and antiemetic combination.

  • Domperidone is an antiemetic agent. It works by blocking dopamine receptors in the digestive system and brain, which helps to increase motility in the upper GI tract and prevent signals that cause nausea and vomiting from reaching the brain. As a result, it aids in faster stomach emptying and prevents reflux, allowing the oesophagus to heal.

  • Sucralfate is a gastroprotective agent. It forms a protective layer that binds to ulcerated tissue in the stomach and duodenum. This barrier shields the damaged areas from further harm caused by stomach acid and bile, facilitating the healing of ulcers. Sucralfate may also stimulate the production of prostaglandin E, which offers protective effects on the stomach lining.

Certified content

Written By

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Ashmita BorgohainMedical Content Writer & Editor| 12 years

MSc (Applied Genetics)

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Domperidone + Sucralfate is available in tablet and oral suspension dosages. This combination is administered orally.

Age and Dose Restrictions

  • Domperidone + Sucralfate is typically prescribed for adults.

  • It can also be used in children, but only under strict medical supervision.

Contraindications

  • Domperidone + Sucralfate is contraindicated in patients with known allergies to either Domperidone or Sucralfate.

  • Individuals with mechanical bowel obstructions, gastrointestinal perforation or bleeding, or a tumour of the pituitary gland are advised not to take this combination.

Other Medications to Avoid

  • Domperidone + Sucralfate may interact with medications such as antifungal agents (like ketoconazole), antibiotics (such as erythromycin), antiviral medicines used in HIV treatment (like ritonavir), and certain heart rhythm medications (like amiodarone).

  • Herbal products like St. John's Wort and grapefruit juice should also be avoided while using this combination.

Overdose and Missed Dose

  • Overdosing on Domperidone + Sucralfate may result in symptoms like irregular heartbeat, tremors, muscle spasms, and severe nausea. If you suspect an overdose, seek immediate medical attention.

  • If you miss a dose of this medication, take it as soon as you remember. However, if your next dose is almost due, skip the missed one and continue with your regular dosing schedule.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • Stay well-hydrated to manage dry mouth symptoms.

  • To manage headaches, rest and relaxation can be beneficial.

  • Taking the medication with a light meal or snack may help prevent stomach discomfort.

Use in Driving and Operating Machinery

  • Domperidone + Sucralfate may cause dizziness or nervousness in some individuals. If affected, it is advised not to drive or operate heavy machinery until these effects subside.

Use in Pregnancy and Lactation

  • The use of Domperidone + Sucralfate during pregnancy and lactation should be considered only if the potential benefits outweigh the potential risks. Always consult your doctor before using this medication if you are pregnant or breastfeeding.

Caution in Other Conditions

  • Patients with kidney problems or certain heart rhythm disorders should exercise caution when taking Domperidone + Sucralfate.

  • Those with liver dysfunction or a history of arrhythmias should also be closely monitored while using this medication.

Special Dietary and Lifestyle Recommendations

  • If you are taking Domperidone + Sucralfate for gastrointestinal issues, it is advisable to follow a balanced diet that includes plenty of fruits, vegetables, and whole grains.

  • Avoid foods and drinks that can irritate your stomach, such as alcohol, caffeine, spicy foods, chocolate, and mint.

  • It is beneficial to eat smaller meals more frequently, rather than three large meals a day.

  • Try not to lie down for at least three hours after eating to prevent reflux symptoms.

Frequently asked questions

No, Domperidone + Sucralfate is not a steroid. Domperidone is an antiemetic and prokinetic agent, and Sucralfate is a gastrointestinal protective agent. Together, they are used to manage stomach pain and discomfort, as well as conditions like gastrointestinal reflux disease (GERD) and stomach and duodenal ulcers.

There is no evidence that Domperidone + Sucralfate directly affects sleep. However, by managing symptoms of GERD such as heartburn and chest pain, it can potentially improve sleep quality indirectly.

There is no scientific evidence suggesting that Domperidone + Sucralfate affects fertility in humans. If you have concerns about fertility, please consult your doctor.

Domperidone + Sucralfate is primarily used to manage conditions like gastroesophageal reflux disease (GERD) and stomach and duodenal ulcers. If you take this medicine without having these conditions, you may not experience any benefit and could potentially experience unnecessary side effects. It's important to take medications only under the advice of a doctor.

Yes, in most cases it is safe to take Domperidone + Sucralfate daily, but your doctor should determine the duration of use based on your specific condition.

The onset of action for these medicines varies from person to person and depends on factors like the severity of symptoms and individual response to medication. Your doctor will be able to provide more precise information.

Domperidone is often recommended to be taken 15-30 minutes before meals and Sucralfate is typically advised to be taken on an empty stomach. It is important to follow the specific instructions provided by your doctor or pharmacist.

Terms & Conditions


Available medicines for DOMPERIDONE + SUCRALFATE
Domsafe 500/5 MG Suspension 100 ML
Domsafe 500/5 MG Suspension 100 ML
Eskag Pharma Pvt.ltd
Pack of 100 ML
₹87.74
MRP ₹107.00
18.00% OFF
Pepsigard P Suspension 100ml
Pepsigard P Suspension 100ml
Saf Fermion Ltd
Pack of 100 ML
₹118.08
MRP ₹144.00
18.00% OFF
Sur D Suspension 100ml
Sur D Suspension 100ml
Chemo Health Care Pvt Ltd
Pack of 100 ML
₹79.34
MRP ₹159.00
50.10% OFF
Pepsigard P Suspension 200ml
Pepsigard P Suspension 200ml
Saf Fermion Ltd
Pack of 200 ML
₹198.44
MRP ₹242.00
18.00% OFF
Sft D Liquid 100 ML
Sft D Liquid 100 ML
Caplet India Private Limited
Pack of 100 ML
₹92.73
MRP ₹113.09
18.00% OFF
Shreyzid Syrup 200 ML
Shreyzid Syrup 200 ML
Converge Biotech
Pack of 200 ML
₹212.75
MRP ₹259.45
18.00% OFF
Sucral D 1000/7.5 MG Suspension 100 ML
Sucral D 1000/7.5 MG Suspension 100 ML
Strassenburg Pharmaceuticals.ltd
Pack of 100 ML
₹112.95
MRP ₹137.75
18.00% OFF

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