Doxofylline
ANTIASTHMATICUses of Doxofylline
- Doxofylline is primarily used for the treatment of Asthma and Chronic Obstructive Pulmonary Disease (COPD).
- Doxofylline is a xanthine derivative used as a bronchodilator.
- It helps in managing chronic bronchitis by reducing airway inflammation and improving lung function.
- It is used to alleviate symptoms of allergic rhinitis by reducing inflammation and constriction in the airways.
Side effects of Doxofylline
- Headache
- Nausea
- Vomiting
- Abdominal pain
- Insomnia
- Irritability
- Increased heart rate
- Rapid breathing
How Doxofylline works
- Doxofylline works by relaxing the smooth muscles in the airways and improving airflow to the lungs.
- It inhibits the enzyme phosphodiesterase (PDE), which leads to an increase in cyclic AMP (cAMP) levels in the cells. Elevated cAMP levels cause relaxation of bronchial smooth muscle, helping to open up the airways.
- By relaxing the bronchial smooth muscles, Doxofylline helps to dilate the airways, making it easier for air to flow into the lungs.
- This is beneficial in conditions where the airways are constricted, such as in asthma and COPD.
- Doxofylline helps to alleviate symptoms such as wheezing, shortness of breath, and coughing by improving airway patency and reducing airway inflammation.
Certified content
Written By
B. Pharm
Reviewed By
B. Pharm, MSc.
Expert Advice
Dosage Forms Available
- Doxofylline can be taken orally (tablet and syrup), sachet (powder) and intravenously (injection).
Age and Dose Restrictions
- Doxofylline tablets, syrup and injections are intended for adults, while the sachet can be used in children above 6 years.
Contraindications
- It is contraindicated in patients with a history of hypersensitivity to Doxofylline and in patients with acute myocardial infarction and hypotension.
Medications to Avoid with This Drug
- Avoid taking antibiotics (erythromycin, lincomycin, and clindamycin), antigout medications (allopurinol), stomach acid reducers (cimetidine), antihypertensives (propranolol), and anticonvulsants (phenytoin). These medications may alter the safety and effectiveness of Doxofylline.
Overdose and Missed Dose
- Overdose can cause irregular heartbeat and tonic-clonic seizures. These symptoms need to be managed as an emergency in a hospital setting. Therefore, strict adherence to the prescribed dose is essential.
- If you miss a dose of Doxofylline, take it as soon as you remember. But, if the next dose is near, skip the missed dose and resume the regular dosing regime.
Management of Side Effects
- Take this combination with food to reduce gastrointestinal side effects and continue taking it as prescribed. If side effects worsen or persist, consult your doctor for a possible treatment plan adjustment.
Use In Driving And Operating Machinery
- This medicine is not known to impair your mental coordination. You can drive, operate machinery, or do other activities that require mental alertness or coordination after taking it.
Use in Pregnancy and Lactation
- Caution is advised in pregnancy. It is not recommended during breastfeeding.
Caution in Other Conditions
- Caution is advised in older adults and in patients with heart disease, hypertension, severe hypoxemia, hyperthyroidism, pulmonary heart disease, congestive heart failure, peptic ulcer, liver disease and kidney impairment.
Special Dietary & Lifestyle Recommendation
- Avoid cigarette smoking as it may increase the clearance of Doxofylline.
- Minimise exposure to allergens like dust mites, pet dander, pollen, or mold, which can trigger bronchospasm. Keep your living environment clean, and consider using air purifiers if necessary.
- Avoid consuming chilled and refrigerated foods, which can act as a trigger for bronchospasm.
- Avoid exposure to smoke, strong odours, and chemical fumes, as they can irritate the airways and trigger bronchospasm.
Frequently asked questions
1. How much time does Doxofylline take to work?
This medicine works within 30 minutes to an hour, relaxing the airways and improving the airflow.
2. Does Doxofylline increase blood sugar levels?
No, this medicine is not known to affect blood sugar levels.
3. Is Doxofylline a habit-forming medicine?
No, this medicine is not habit-forming and is generally safe when used as directed.
4. Is Doxofylline available over the counter, or do I need a prescription?
This medicine usually requires a prescription and is unavailable over the counter.
5. Does Doxofylline affect fertility?
This medicine is not known to affect fertility. This medication is primarily used for respiratory conditions and is not associated with fertility-related side effects.
6. Does Doxofylline cause dry mouth?
This medicine is not known to cause dry mouth as a side effect.
7. Is Doxofylline used to prevent asthma attacks?
This medicine is not typically used to prevent asthma attacks. They are more commonly employed to manage symptoms and improve respiratory function in chronic obstructive pulmonary disease (COPD) and bronchial asthma, relaxing the airways and improving the airflow.
Doxofylline in other salts
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