Doxofylline

Dosage Forms Available

• Doxofylline can be taken orally (tablet and syrup), sachet (powder) and intravenously (injection).

Age and Dose Restrictions

• Doxofylline tablets, syrup and injections are intended for adults, while the sachet can be used in children above 6 years.

Contraindications

• It is contraindicated in patients with a history of hypersensitivity to Doxofylline and in patients with acute myocardial infarction and hypotension.

Medications to Avoid with This Drug

• Avoid taking antibiotics (erythromycin, lincomycin, and clindamycin), antigout medications (allopurinol), stomach acid reducers (cimetidine), antihypertensives (propranolol), and anticonvulsants (phenytoin). These medications may alter the safety and effectiveness of Doxofylline.

Overdose and Missed Dose

• Overdose can cause irregular heartbeat and tonic-clonic seizures. These symptoms need to be managed as an emergency in a hospital setting. Therefore, strict adherence to the prescribed dose is essential.
• If you miss a dose of Doxofylline, take it as soon as you remember. But, if the next dose is near, skip the missed dose and resume the regular dosing regime.

Management of Side Effects

• T​​ake this combination with food to reduce gastrointestinal side effects and continue taking it as prescribed. If side effects worsen or persist, consult your doctor for a possible treatment plan adjustment.

Use In Driving And Operating Machinery

• This medicine is not known to impair your mental coordination. You can drive, operate machinery, or do other activities that require mental alertness or coordination after taking it.

Use in Pregnancy and Lactation

• Caution is advised in pregnancy. It is not recommended during breastfeeding.

Caution in Other Conditions

• Caution is advised in older adults and in patients with heart disease, hypertension, severe hypoxemia, hyperthyroidism, pulmonary heart disease, congestive heart failure, peptic ulcer, liver disease and kidney impairment.

Special Dietary & Lifestyle Recommendation

• Avoid cigarette smoking as it may increase the clearance of Doxofylline.
• Minimise exposure to allergens like dust mites, pet dander, pollen, or mold, which can trigger bronchospasm. Keep your living environment clean, and consider using air purifiers if necessary.
• Avoid consuming chilled and refrigerated foods, which can act as a trigger for bronchospasm.
• Avoid exposure to smoke, strong odours, and chemical fumes, as they can irritate the airways and trigger bronchospasm.