Dydrogesterone + Estradiol

Dosage Forms Available

• DYDROGESTERONE + ESTRADIOL is available for use via oral route in the form of tablets.

Age and Dose Restrictions

• This medicine is intended for use in adult women, particularly those experiencing menopausal symptoms or postmenopausal osteoporosis.

Contraindications

• DYDROGESTERONE + ESTRADIOL is contraindicated in women with known or suspected breast cancer, estrogen-dependent neoplasia, undiagnosed genital bleeding, untreated endometrial hyperplasia, active deep vein thrombosis, pulmonary embolism, recent history of these conditions, known liver dysfunction or disease, and known or suspected pregnancy.

Other Medications to Avoid

• Dydrogesterone + Estradiol may interact with blood pressure-lowering medicines (such as amlodipine, losartan), anticoagulants (such as warfarin, dabigatran), and anticonvulsants (such as phenytoin, carbamazepine). It can also interact with certain antibiotics (such as rifampicin erythromycin), antifungals (such as ketoconazole and itraconazole), and other hormone therapies (such as levothyroxine insulin).

Overdose and Missed Dose

• An overdose of DYDROGESTERONE + ESTRADIOL may cause nausea, vomiting, dizziness, vaginal bleeding, or tenderness in the breasts. If you suspect an overdose, seek immediate medical attention.
• If you forget to take your dose of DYDROGESTERONE + ESTRADIOL, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose. Do not double up to make up for a missed dose.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• For nausea, try taking the medicine with food or milk. Drinking plenty of water can also help.

• If you experience headaches, resting in a quiet, dark room may offer some relief.

  Use in Driving and Operating Machinery

• DYDROGESTERONE + ESTRADIOL may cause dizziness or fatigue. If affected, avoid driving or operating heavy machinery until you feel well enough to do so.

Use in Pregnancy and Lactation

• DYDROGESTERONE + ESTRADIOL should not be used during pregnancy or while breastfeeding unless specifically advised by your doctor.

Caution in Other Conditions

• Women with a history of venous thromboembolism, arterial thromboembolic disease, liver disease, or known thrombophilic disorders should use Dydrogesterone + Estradiol with caution.

Special Dietary and Lifestyle Recommendations

• Regular physical activity can help manage some menopausal symptoms and maintain bone health.
• Consuming a diet rich in calcium and vitamin D can support bone health.
• Limiting caffeine and alcohol may help reduce hot flashes and night sweats.
• Smoking cessation is recommended, as smoking can increase the risk of heart disease, stroke, and osteoporosis.