Edaravone
Uses of Edaravone
The primary use of Edaravone is for managing symptoms and delaying the progression of Amyotrophic Lateral Sclerosis (ALS), a neurodegenerative disease. It falls under the category of neuroprotective and antioxidant medicines.
Side effects of Edaravone
Nausea
Vomiting
Headache
Bruising
Red, itchy, or scaly rash
How Edaravone works
Edaravone is an antioxidant and neuroprotective medicine.
It primarily works by neutralising harmful free radicals in the brain. These free radicals cause oxidative stress, a condition that contributes to the degeneration of nerve cells in diseases like amyotrophic lateral sclerosis (ALS; nervous system disease that affects nerve cells in the brain and spinal cord). By counteracting these free radicals, this medicine reduces oxidative stress and slows down the nerve cell damage process. This prevents the worsening of ALS symptoms, thus causing delay in the progression of the disease.
Certified content
Written By
BDS, MDS
Reviewed By
Bachelor of Dental Surgery
Expert Advice
Dosage Forms Available
- Edaravone is available for use via intravenous (injection solution) and oral (suspension) routes.
Age and Dose Restrictions
- Edaravone is typically used for adults. Specific use for children is not typically recommended due to limited data on safety and efficacy.
Contraindications
- This medicine is contraindicated in patients with known hypersensitivity to Edaravone or any of its components, including sulfites. Patients with a history of severe asthma should also avoid using this medication due to potential allergic reactions.
Other Medications to Avoid
- This medicine may interact with other antioxidants (e.g., Vitamin C and E), and certain antihistamines (e.g., diphenhydramine and loratadine).
Overdose and Missed Dose
- An overdose of Edaravone may result in severe symptoms such as respiratory failure. Immediate medical attention is required in case of overdose.
- If you miss a dose of this medicine, inform your doctor immediately to reschedule the treatment. Do not double the next dose to make up for the missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any symptoms, please consult your doctor.
- Drinking water can help manage some of the gastrointestinal side effects such as nausea and vomiting.
- Skin rashes may be managed by avoiding harsh soaps or skin products.
Use in Driving and Operating Machinery
- Edaravone does not usually affect the ability to drive or operate machinery. However, if you feel dizziness or fatigue after taking this medicine, avoid driving or operating heavy machinery.
Use in Pregnancy and Lactation
- The safety of Edaravone during pregnancy and breastfeeding has not been established. It is recommended to consult your doctor before using this medicine if you are pregnant or breastfeeding.
Caution in Other Conditions
- Patients with renal or hepatic impairment should use Edaravone under close medical supervision as the safety and efficacy in these patients have not been evaluated.
Special Dietary and Lifestyle Recommendations
- Drink plenty of water to help manage nausea or constipation.
Frequently asked questions
How Long Does Edaravone Stay in Your System?
Edaravone has a half-life of around 4.5 to 6 hours, which means it takes about this time for half of the medicine to be eliminated from the body. However, it may take several days for the entire drug to be completely eliminated depending upon individual metabolic rates.
Does Edaravone Need Any Medical Tests or Monitoring?
Regular monitoring is not usually required while using Edaravone. However, your doctor might ask for specific tests if you experience any severe or persistent side effects.
Can Edaravone Cause Allergies?
Edaravone can cause allergic reactions in some patients, especially those with a history of hypersensitivity to Edaravone or any of its components, including sulfites.
Are There Any Natural Alternatives to Edaravone?
There are no natural alternatives that have been proven to have the same effect as Edaravone in slowing down the progression of ALS symptoms.
Is There a Vegetarian Version of Edaravone available?
Edaravone is administered via intravenous infusion and does not contain any animal-derived ingredients, making it suitable for vegetarians.
Can I Become Addicted to Edaravone?
No, Edaravone does not cause addiction or dependency. However, always use it as prescribed by your doctor.
Will Edaravone Improve My Cognitive Abilities?
No, Edaravone will not enhance cognitive abilities. It is an antioxidant that helps manage ALS symptoms by reducing oxidative stress in the brain. It does not improve memory or intelligence.
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