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Epalrestat

Uses of Epalrestat

  • The primary use of Epalrestat is in managing diabetic neuropathy, a condition where high blood glucose levels damage nerves, primarily affecting the legs and feet. It belongs to the category of aldose reductase inhibitors.

  • Secondary uses of Epalrestat are currently being investigated in clinical trials, including one for metastatic triple-negative breast cancer.

Side effects of Epalrestat

  • Nausea

  • Vomiting

  • Diarrhoea

  • Dizziness

  • Abnormal Liver Function Tests

How Epalrestat works

  • Epalrestat is a reversible aldose reductase inhibitor.

  • It works by blocking the enzyme aldose reductase, which usually converts glucose to sorbitol. In people with diabetes, high blood sugar levels cause this enzyme to become overactive, leading to excess sorbitol buildup in nerves, which can damage them. By inhibiting aldose reductase, Epalrestat helps reduce sorbitol accumulation and protects nerve function.

Certified content

Written By

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Dr. Michelle FrankMedical Content Writer| 8 years

Doctor of Medicine

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Epalrestat can be taken orally (tablets).

Age and Dose Restrictions

  • Epalrestat is primarily prescribed to adults aged 18 and above.

Contraindications

  • Epalrestat should not be used in patients who have a known hypersensitivity to the medicine or any of its components. It is contraindicated in individuals suffering from diabetic ketoacidosis.

Other Medications to Avoid

  • Epalrestat may interact with other antidiabetic medications (such as metformin), medicines affecting liver enzymes (like rifampin), and antioxidants (such as vitamin E). These interactions can influence its effectiveness and safety.

Overdose and Missed Dose

  • Overdosing on Epalrestat may lead to increased severity of side effects such as nausea, vomiting, and diarrhoea. In case of suspected overdose, seek immediate medical attention.

  • If you miss a dose, take it as soon as you remember unless it is almost time for the next dose. Do not double the dose to compensate for a missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • Nausea and vomiting can be managed by taking Epalrestat with food.

  • Drinking plenty of water can help reduce dizziness and headaches.

  • Resting in a quiet, dark room may help manage headaches.

Use in Driving and Operating Machinery

  • Epalrestat may cause dizziness as a side effect. If you feel dizzy after taking this medicine, avoid driving or operating heavy machinery until you feel well again.

Use in Pregnancy and Lactation

  • Epalrestat is not recommended during pregnancy or while breastfeeding. It is always advisable to consult your doctor if you are pregnant, planning to become pregnant, or are breastfeeding.

Caution in Other Conditions

  • Patients with liver disease should exercise caution when taking Epalrestat as it may require dose adjustments. Similarly, patients with kidney dysfunction may need dose adjustments based on renal function.

Special Dietary and Lifestyle Recommendations

  • Regular monitoring of blood sugar levels is important to ensure the effectiveness of the medication.

Frequently asked questions

No, Epalrestat is not a steroid. It belongs to a class of medications known as aldose reductase inhibitors, which are designed to manage diabetic neuropathy.

Epalrestat does not cause sleeping problems. However, individual reactions to medications can vary. If you experience sleep disturbances after starting this medication, consult your doctor.

Epalrestat is not known to directly affect fertility. If you are planning a family or if you have concerns about fertility, it would be best to discuss this with your doctor.

Yes, a prescription is usually required to purchase Epalrestat as it is used for managing specific medical conditions like diabetic neuropathy.

Yes, it is safe to take Epalrestat daily as directed by your doctor. It is typically prescribed as a long-term treatment for diabetic neuropathy, and regular use is necessary for the medication to be effective.

Epalrestat may begin showing effects after several weeks of consistent use. However, it may take several months before its full benefits can be felt.

No, Epalrestat is not a painkiller. It is used to manage diabetic neuropathy by improving nerve function.

Terms & Conditions


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