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Ethambutol + Isoniazid

Uses of Ethambutol + Isoniazid

  • Ethambutol + Isoniazid is primarily used for the management of all forms of tuberculosis, and belongs to the group of anti-tuberculosis medicines.

  • In addition to its primary use, it is also employed for the prevention of tuberculosis in people who have been exposed to patients with active tuberculosis, a condition known as latent tuberculosis infection (LTBI).

Side effects of Ethambutol + Isoniazid

  • Nausea and vomiting

  • Loss of appetite

  • Fatigue

  • Dizziness

  • Joint pain

  • Headache

How Ethambutol + Isoniazid works

  • Ethambutol + Isoniazid is an antibacterial combination.

  • Ethambutol hinders the metabolism of the tuberculosis-causing bacteria. It specifically disrupts arabinogalactan synthesis, a crucial component of the bacterial cell wall, thus inhibiting the growth of these harmful bacteria.

  • Isoniazid is effective against rapidly multiplying tuberculosis bacteria. It prevents mycolic acid formation, which is an integral part of the bacterial cell wall. It is a pro-drug and needs to be activated by a bacterial enzyme called KatG, which acts as a catalase-peroxidase.

Certified content

Written By

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Dr. Michelle FrankMedical Content Writer| 8 years

Doctor of Medicine

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage forms available

  • Ethambutol + Isoniazid is available for oral administration as tablets.

Age and dose restrictions

  • Ethambutol + Isoniazid is suitable for adults and children who are aged 1 month and older.

Contraindications

  • This medicine is contraindicated in patients with a known allergy to ethambutol or isoniazid.

  • Patients with severe liver damage or acute liver disease should not take Ethambutol + Isoniazid.

Other medications to avoid

  • Ethambutol + Isoniazid may interact with antacids containing aluminium (such as aluminium hydroxide or magnesium trisilicate), anticoagulants (such as warfarin), antiepileptic medicines (like phenytoin and carbamazepine), and bronchodilators (such as theophylline).

  • Before starting any over-the-counter medicines, it is crucial to consult your doctor, as using them with Ethambutol + Isoniazid needs careful monitoring.

Overdose and missed dose

  • Overdosing on Ethambutol + Isoniazid could lead to serious side effects such as vision problems, severe liver damage, skin rashes, hives, or itching. If you suspect an overdose, seek immediate medical attention.

  • If you miss a dose of this medicine, take it as soon as you remember. However, avoid taking the missed dose if it is almost time for your next dose. Do not take a double dose to make up for a missed one.

Management of side effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • For nausea or stomach upset, try taking the medicine after meals.

  • Stay well hydrated to manage side effects like dizziness and fatigue.

  • Rest and sleep well to manage headaches.

Use in driving and operating machinery

  • Ethambutol + Isoniazid may cause dizziness or fatigue. If you experience these side effects, avoid driving or operating heavy machinery until you feel better.

Use in pregnancy and lactation

  • The use of this medicine during pregnancy or breastfeeding is not recommended without doctor's advice. It is best to consult your doctor before taking this medication if you are pregnant or nursing.

Caution in other conditions

  • Patients with kidney problems, liver disease, or those who consume alcohol regularly should exercise caution when taking Ethambutol + Isoniazid.

  • Patients with vision issues should also be careful as this medicine can cause vision problems.

Special dietary and lifestyle recommendations

  • Maintain a balanced diet rich in fruits, vegetables, lean proteins and whole grains to support overall health while managing tuberculosis.

  • Regular physical activity such as walking can help improve lung capacity and overall health.

  • Ensure adequate rest and sleep to aid recovery.

  • Avoid alcohol as it can increase the risk of liver damage when taking Ethambutol + Isoniazid.

  • Avoid smoking as it can worsen tuberculosis and lung health.

Frequently asked questions

No, Ethambutol + Isoniazid is not a steroid. It is a combination of two antibacterial medicines that are used to manage tuberculosis.

Ethambutol + Isoniazid may cause side effects like insomnia or vivid dreams in some individuals. Consult your doctor if you notice any significant changes in your sleep pattern.

There is no direct evidence to suggest that Ethambutol + Isoniazid affects fertility. If you have concerns about fertility while taking this medication, it is best to discuss them with your doctor.

While on Ethambutol + Isoniazid, it's advisable to avoid consuming alcohol and foods rich in tyramine (e.g., aged cheeses, cured meats), as they can interfere with the effectiveness of the medications or increase side effects. Follow your doctor's dietary recommendations for optimal treatment.

Yes, it is safe to take Ethambutol + Isoniazid daily as per the prescribed dosage and duration recommended by your doctor.

The exact time may vary based on the severity and type of the tuberculosis infection. Always follow your doctor’s advice regarding the duration of treatment.

Ethambutol + Isoniazid should be taken as prescribed by your doctor. No specific time of day is indicated in the reference data.

Terms & Conditions


Available medicines for ETHAMBUTOL + ISONIAZID
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Marconex 300/800 MG Tablet 10
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Econex 300/800 MG Tablet 6
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