Ezetimibe
Uses of Ezetimibe
The primary use of Ezetimibe is to manage high cholesterol levels in the blood. It belongs to the group of medications known as cholesterol absorption inhibitors.
It also assists in the management of primary hypercholesterolemia (high cholesterol), mixed hyperlipidemia (high levels of different types of fats in the blood), homozygous familial hypercholesterolemia (a severe genetic form of high cholesterol), and homozygous sitosterolemia (a rare genetic condition characterised by high levels of certain plant sterols in the blood).
Side effects of Ezetimibe
Upper respiratory infections like sinus infections and sore throat
Diarrhoea
Joint pain
Pain in the arms or legs
How Ezetimibe works
Ezetimibe is a cholesterol absorption inhibitor.
It works by reducing the amount of cholesterol absorbed from your intestines into your bloodstream. This reduction is due to Ezetimibe's ability to block a specific transport protein called Niemann-Pick C1-Like 1 protein, which moves cholesterol from the intestines into the bloodstream. By decreasing intestinal absorption, less cholesterol reaches your liver and the levels in the blood drop. Ezetimibe does not have significant effects on the absorption of fat-soluble vitamins, triglycerides, or bile acids.
Certified content
Written By
BDS, MDS
Reviewed By
BAMS, APG, PG
Expert Advice
Dosage Forms Available
Ezetimibe is available in an oral formulation as tablets.
Age and Dose Restrictions
This medicine is meant for adults and children above the age of 10 years.
Contraindications
Ezetimibe is contraindicated in patients with active liver disease or unexplained persistent elevations of liver enzymes.
Other Medications to Avoid
Ezetimibe may interact with immunosuppressive medications (e.g., cyclosporine), lipid-modifying medications (e.g., fibrates), bile acid sequestrants (e.g., cholestyramine), and anticoagulants (e.g., warfarin).
Overdose and Missed Dose
Overdose may cause symptoms like headache, diarrhoea or arthralgia. If you suspect an overdose of Ezetimibe, seek immediate medical attention.
If you miss a dose of Ezetimibe, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and continue with your regular schedule.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing Ezetimibe. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of water may help manage side effects like diarrhoea.
For relief from joint pain or discomfort in the arms or legs, try using warm compresses.
Rest and hydration can help manage symptoms of upper respiratory infections like sinus infections and sore throat.
Use in Driving and Operating Machinery
Use caution while driving or operating machinery after taking Ezetimibe as it can occasionally cause dizziness or fatigue.
Use in Pregnancy and Lactation
Ezetimibe is not recommended during pregnancy and lactation unless prescribed by your doctor. Consult your doctor before using this medicine if you are pregnant, planning a pregnancy, or breastfeeding.
Caution in Other Conditions
Ezetimibe can be used with caution in patients with kidney problems as no dosage adjustment is needed. However, individuals with moderate to severe liver impairment should use this medicine cautiously.
Special Dietary and Lifestyle Recommendations
A diet low in saturated fats and cholesterol can support the effects of Ezetimibe in lowering cholesterol.
Regular health check-ups and cholesterol level monitoring can help track the effectiveness of Ezetimibe and adjust the treatment plan if necessary.
Frequently asked questions
Is Ezetimibe a steroid?
No, Ezetimibe is not a steroid. It belongs to the class of medicines known as cholesterol absorption inhibitors.
Does Ezetimibe have any effect on sleep?
Ezetimibe is not known to directly affect sleep. If you experience sleep disturbances while taking this medicine, please consult your doctor.
Will Ezetimibe affect fertility?
Ezetimibe is not known to have any impact on fertility. However, if you have concerns about fertility, it is advisable to discuss them with your doctor.
Is it safe to take Ezetimibe daily?
Yes, it's recommended to take Ezetimibe as prescribed by your doctor on daily basis for long-term use, as it is generally well-tolerated.
How much time does Ezetimibe take to work?
The cholesterol-lowering effects of Ezetimibe are usually seen within 2 weeks of starting the medication, with the maximum effect observed after 4 weeks.
Is Ezetimibe available over the counter, or do I need a prescription?
Ezetimibe is a prescription medicine and is not available over the counter.
Does taking Ezetimibe affect menstrual cycles?
Ezetimibe is not known to affect menstrual cycles, but if you experience any menstrual irregularities, consult your doctor.
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